DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43367 and nbeaa

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	NP_001013518.2	Gene:	nbeaa / 541373	ZFINID:	ZDB-GENE-050320-68	Length:	2998	Species:	Danio rerio

Alignment Length:	3103	Identity:	658/3103 - (21%)
Similarity:	1050/3103 - (33%)	Gaps:	1143/3103 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 MLRLLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLTAESLAENCVQN-L 546
            |:.||.......:.|...:.:.:|:....|.:|.|..   .:|:.|    |...|..::.:.: |
Zfish   117 MVELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEV---GLIQQV----LQKMSAVDDMIADLL 174

  Fly   547 IKLIEELSKLSIVPAELKCIFSLLRQGTKFPQFKQLQQTLVVIALQSLRGSNSCAEFFSIE-QPT 610
            :.::..|:..||...|||.:||:||..........::...|:..:....|.::   ||:.. :..
Zfish   175 VDMLGVLASYSITVKELKLLFSMLRGDAGVWPRHAIKLLSVLNQMPQRHGPDT---FFNFPGRSA 236

  Fly   611 DGILVPDIRNWTISGSYGFIFHILVRFNQLK--EQSNSRRMLLTLQTASGSGFEV-FVQPNGNVV 672
            ..|.:|.|..|....  ||..:...|.:.|.  .....:..|...:|:.|.|:.. ||   ||.:
Zfish   237 AAIALPPIAKWPYQN--GFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGIGYSAHFV---GNCL 296

  Fly   673 VAALTRREYLTSSTATKTLMDGQWHYLTVAITPPK----------RPFSYSQINIYVDFVQKLSA 727
            :.           |:.|:...|..|.:.....|.|          ..:..|:|..||:
Zfish   297 IV-----------TSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVN------- 343

  Fly   728 TLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSN 792
                                     |::...|:|
Zfish   344 -------------------------GQLVSYGDM------------------------------- 352

  Fly   793 YFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQT-CLNGHLGGVLLADPTTSLKTIF---DAGANFS 853
              ...:.|..::|   |.| :|..:|....:. |  |.||.|.:.....:...||   ..|..:.
Zfish   353 --AWHVNTNDSYD---KCF-LGSSETADANRVFC--GQLGAVYVFSEALNPAQIFAIHQLGPGYK 409

  Fly   854 SIF----SQDNDLLE----------LNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIV 904
            |.|    ..|..|.|          |.|...|.|...|.....|.:..|.......:::.|..::
Zfish   410 STFKFKSESDIHLAEHHKQVLYDGKLASSISFTYNAKATDAQLCLESSPRENASIFVHSPHALML 474

  Fly   905 K---------IQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWE 960
            :         |...|:|||||..:.|:..:| ...|..|..:     |:..|
Zfish   475 QDVKAIVTHSIHSAIHSIGGIQVLFPLFSQL-DYRQPNDSPV-----ETTVC------------- 520

  Fly   961 MLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALM 1025
                             |:.|..|..|.......|||:|..:...::|.:|::.       :.:.
Zfish   521 -----------------ATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKS-------SRVH 561

  Fly  1026 ATHLLMES-------LQG--HKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKN 1081
            .|..::|.       |.|  |    |..||..|..|::|:.|||.....::.|....||||....
Zfish   562 ITRAVLEQFLSFAKYLDGLTH----GAPLLKQLCDHVLFNAAIWIHTPAKVQLSLYTYLSAEFIG 622

  Fly  1082 DRKFFR--KRYG-VQFVLDVVRQYY----------STPDSI-----SDDDAKTIRATLFGIIKFY 1128
            ....:.  :|.| |..::..::.||          .||..:     |..:..::||.:...:|..
Zfish   623 TATIYSTIRRVGTVLQLMHTLKYYYWASNPLESSGITPKGLDGPRPSQKEIISLRAFMLLFLKQL 687

  Fly  1129 LQKDVNIK--EVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQS-------- 1183
            :.||..:|  |:.|::.:|.::.:|..:.:.|:::            :.|:...|.|
Zfish   688 ILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLL------------VALMSEHPASMIPAFDQR 740

  Fly  1184 --ANLLYNFFVDKSYSNEIQEAAIRFISGLLATSRVHQKYKQVLR-------------------- 1226
              ..::|.....||.|..:|  |:: :.|.......|::..:::.
Zfish   741 NGIRVIYKLLASKSESIRVQ--ALK-VLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMMHTSTVT 802

  Fly  1227 ------LYDQTTEQ------------------SMFPGFFSFITPLSLSSTILFHLVD-------E 1260
                  ||:..|||                  ...|.....:..|..||:....|::       :
Zfish   803 ITTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKSSSPSAELMEVRRLFLSD 867

  Fly  1261 MLGL------------------------------QPDYAGLIFLVYHV----------------- 1278
            |:.|                              .|:...:..:||::
Zfish   868 MIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNPEEQKITEMVYNIFRILLYHAIKYEWGGWR 932

  Fly  1279 ------SSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITSSPPDEEKRR 1337
                  |.....|..|..|..|...:.:.|.......:.|.:.|::.:   ..:::.|      .
Zfish   933 VWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGSVSTI---SGLSAQP------T 988

  Fly  1338 SFGINLDVL-LEDNSNFLAQADLITFSE---QEIGLAQLQQQQQE-ELSDSGL------ILNEIQ 1391
            |...||::. ::|.|........:.:.|   ..|.||:.:..:.| |.|.:|:      :|.:|:
Zfish   989 SVNGNLEIREIDDTSQTQTPESEVDYGENADSRILLAEAKVPESEAESSAAGVRVEVHDLLVDIK 1053

  Fly  1392 ASVTEAATV-----------------IES----EIKELAESVSGAVVENANSLF------SVIRQ 1429
            |...||..|                 :|:    |:..|.:|...|.|...|...      ||:..
Zfish  1054 AEKVEATEVKLDDLDLSPEVLGGGGGMENGPLVEVDSLLDSAYCAAVHKLNGSLVPKEEESVVVG 1118

  Fly  1430 TTHD---------LQDTFESL----------------------------------------TQGS 1445
            .|.|         |.|..:|:                                        |..:
Zfish  1119 LTEDDGNMGPLITLADEKDSVPSNNGFLFPKVDEKLLPSLASTEPLVLPSPDQPPCSTTPHTSSA 1183

  Fly  1446 STD-------TADGS---QTPS---------------------------------IQREE----- 1462
            |.|       |:.||   ||||                                 :::|.
Zfish  1184 SDDLSLLAHMTSCGSDLVQTPSGLEDDGFKLQSSLADISTLAEAEAQAAARTAECLEQESGDARA 1248

  Fly  1463 --------SLSSDT------------------SSQSPHGPPKKSDSLESTSAFDFVADGDVDTEE 1501
                    |.:|||                  ::|:.||  :.|..:|.....|....|...|||
Zfish  1249 GKSSGDAASTTSDTERSDDGKDKEMKKIQTTATTQALHG--RMSGQMERDLRVDLGFRGMPMTEE 1311

  Fly  1502 Q---------------------------------------------------------------- 1502
            |
Zfish  1312 QRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALESDVHMWRSHSTKSVMDFVNSNENIIFVH 1376

  Fly  1503 -LVYLVSNTLFNIF--WRGI------------------PNDHPQCWQERGQVLGCINLL------ 1540
             .::|:|..:.||.  ..||                  |.....|.| :|.....:|.|
Zfish  1377 NTIHLISQMVDNIIIACGGILPLLSAATSPSSSKVSANPTQGSSCLQ-KGAKSSEVNSLPGSSGT 1440

  Fly  1541 -------------ALNNELITSHLSLRLRILEMAVQASLFDLSE--------------------- 1571
                         .:::|...:.||..:.::::.|.||..:.||
Zfish  1441 GVETELENVEATQGMSSETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVC 1505

  Fly  1572 ----------------HGSQTLV----NQEN---ASHILRMVYELV------------------- 1594
                            .||:|.:    .|||   |:...:.|.:.|
Zfish  1506 CVAVRNCLECRQRQRDRGSKTSLPISKTQENLQTAASASKTVIQNVPRNLSPIKDPDRLLQDVDI 1570

  Fly  1595 -----VLGSNEDESKKCSTKLLDGVLALLDALMIFQQ----------GSSDD------------- 1631
                 |:..:.|:||:.....| .|:..:..||:.:.          |.|..
Zfish  1571 NRLRAVVFRDVDDSKQAQFLAL-AVVYFISVLMVSKYRDILEPQREIGRSSSLSGRSIRQEINSP 1634

  Fly  1632 --------WSDMIR--------------------------------------------------- 1637
                    :||.:|
Zfish  1635 TSTENPSLFSDGVRGERQAMTPLEDLPLEASLPHTDSGIGEEQVTGALNGSDLGTDHHSGLVGGS 1699

  Fly  1638 ---------LC-----------------LGL-----------------------LLKC------- 1646
                     ||                 ||:                       :||.
Zfish  1700 GGPDAMSELLCTLSSEVRKSSESLLESPLGVEVLKPAASISSISQANKGINVKEILKSLVAAPVE 1764

  Fly  1647 ---------SHHPN--------------------------------------------------- 1651
                     .:||:
Zfish  1765 GAEAGPEPQPYHPDPALKREAAAMLPMQFHSFDRSVVVPVKKPPPGSLAVNTVGTPTSGAVPSSG 1829

  Fly  1652 --PGIVAMATAKLHAILQSRSTEDPAELSYLLYS--INRALDN---AIEVGNPEEYSFLMPV--- 1706
              |.|.|.|||...:::.:....|.|..|....|  :|.|...   |::...|      ||.
Zfish  1830 STPNIFAAATATPKSMINTTGATDSASSSSSSSSSFVNGATSKNLPAVQTVAP------MPEDTV 1888

  Fly  1707 --MKALLEKCRVAFNLDSTLPDLPSTSS----------------------------GPV---FFN 1738
              |.|..|..:.......|.|:|.|.||                            .|:   .|.
Zfish  1889 ENMSAFCEVDQCPLRTRLTPPELKSFSSLTGFQTAPRDAGQFLSITTKLERALEKVAPLLREIFV 1953

  Fly  1739 DFQ-----------------------------------MYSTSKKWRNFIERMVKPLYDRYQRDI 1768
            ||.                                   |...|::|:|.|           |::.
Zfish  1954 DFAPFLSRTLLGSHGQELLIEGTGLVCMKSSTSVVELVMLLCSQEWQNSI-----------QKNA 2007

  Fly  1769 ELHLWEPINRFWAECY-----------EACKAASKQRATNQAENRRLFQQKIYMPWKVRQVEEMQ 1822
            .|...|.||.....|:           ||....::|||.:..::..............|:.|:|.
Zfish  2008 GLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESNCAQYAADRREEEKMC 2072

  Fly  1823 RLQAAALQHKTIDSHIRKRWKTAK--RFLYGPRGPWYTGEVDE--EFWKLSQHENVARMRLKLEP 1883
            ....:|.:|:   .|:.......|  ..|....|.|.|....:  :||:|...|:..|.|.:...
Zfish  2073 DHLISAAKHR---DHVTANQLKQKILNILTNKHGAWGTMSQSQLHDFWRLDYWEDDLRRRRRFVR 2134

  Fly  1884 QLYPNKHENAANLRDNATSAYDTKEISEF-----------DSTIKNAVVRD-------FLADDES 1930
            ..:.:.|.:..           .|.:.|:           .|...::||..       ...||::
Zfish  2135 NAFGSTHTDVT-----------LKSLEEYGPEEEEGMKSKKSFRSHSVVSQNPETELMLEGDDDA 2188

  Fly  1931 SQLEEELRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTF-VDLSPPT----- 1989
            ..|.:|  :.||..|      ..:|:|...:|:..:...:|.:.:..:...| ||...||
Zfish  2189 VSLLQE--KEIDNLA------GPVVLSTPAQLVAPVIVARGTLSITTTEIYFEVDEDDPTFKKID 2245

  Fly  1990 ------EDGSKYDFRFSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFTTK-TRNKVFTKIVG 2047
                  .:|....:.||  :||.|..|:|.|:.:.||:|:.::||...||..: |..||   :..
Zfish  2246 AKVLGYTEGLHGKWMFS--EIRAVFSRRYLLQNTGLEVFMANRTSVMFNFPDQATVKKV---VYS 2305

  Fly  2048 LP---------LPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYP 2103
            ||         ||.....|..:|.:|.::|.:||||..||||||||||:|||||||:||||:|||
Zfish  2306 LPRVGVGTSYGLPQARRISLATPRQLFKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYP 2370

  Fly  2104 VFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSN 2168
            ||||:|.:|.|:.||||.|.:|||||||||.:|||.......:|:::|| .||.| .||.:.||.
Zfish  2371 VFPWVLTNYESEDLDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWED-DGAAP-HHYSSLYST 2433

  Fly  2169 SAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLK 2233
            :|..|::|:|:||||:..::....:||..||.|..|.::|:....:.:||:||||||:|.||...
Zfish  2434 AASTLYWLVRIEPFTTFFLNCNENKFDHPDRTFSGIARSWRSCQRDTSDVRELIPEFYYLPEMFV 2498

  Fly  2234 NMNKFDLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPK 2298
            |.:.:||| ::..:..|.||.||.||..||:|:.|:|.|||||:||..||.||||||||||:||:
Zfish  2499 NSSGYDLG-VREDRTAVCDVELPVWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPE 2562

  Fly  2299 AAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVR 2363
            |..|||||:|.||||:::||.||:|..||::|..|.:|||.|||||.||||.|    .:|:.|
Zfish  2563 AVRALNVFHYLSYEGSINLDTITDPQLRESMEAQIQSFGQAPSQLLIEPHPPR----SSAMHL-- 2621

  Fly  2364 AELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPP------RSFLQLSPDVLVSISKSTIL 2422
            ..|.:..| .|.|::.|         |.|:.|..|.:.|      .:...||....|:::.|.:.
Zfish  2622 CFLPQSPL-MFKDQMQQ---------DVIMVLKFPSNSPVTHVAANTLPHLSIPAAVTVTCSRLF 2676

  Fly  2423 GCNSW-----------LSFDKDQGFLLEIDATTANLK--NRKRIFGPFHSSQQPHSQLFAVSTDG 2474
            ..|.|           .|.::.....:|:|:..||..  ::::|......|.|.::..|.|:.|.
Zfish  2677 AVNRWHNTVGLRGAPGYSLEQAHHLPIEMDSLIANNSGISKRQITDLVDQSIQINTHCFVVTADN 2741

  Fly  2475 KLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALD------NCGSYLVTGSRDCTCIVWS 2533
            :.:.|.|.||.|.|||:...||....|..|.|::||:|..      :|  |:|:||||.|.::|
Zfish  2742 RYILACGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDC--YIVSGSRDATLLLW- 2803

  Fly  2534 IQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVV 2598
                             ..:|:.|   |...|..||..|.|..||.|||..:..|::..||.||:
Zfish  2804 -----------------YWSGRHH---IIGDNPNNSDYPAPRAVLTGHDHEVVCVSVCAELGLVI 2848

  Fly  2599 SGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTLSYHGH-IAFSALDDTSHSVHVYSING 2662
            ||:.:|...|:|: .|..:|.|:.   .|:|::...:::|..|| |.:.......:    :||||
Zfish  2849 SGAKEGPCLVHTI-TGDLLRALEG---PENCLRPRLISVSSEGHCIIYYERGQFCN----FSING 2905

  Fly  2663 CSLGSKYV--SGRVTGLASASDYLVVADDAGDITMSRLHGLKPVFDIP 2708
            ..|....:  |.|...|:|....||...|.|.:.:.:....|.::..|
Zfish  2906 KLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYP 2953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605	18/119 (15%)
		DUF4704	906..1162	CDD:292415	61/284 (21%)
		DUF4800	1650..1899	CDD:292675	64/392 (16%)
		PH_BEACH	1952..2046	CDD:275391	28/106 (26%)
		Beach	2072..2351	CDD:280327	156/278 (56%)
		WD40	<2428..2734	CDD:225201	83/292 (28%)
		WD40 repeat	2465..2503	CDD:293791	14/37 (38%)
		WD40	2468..2687	CDD:295369	71/227 (31%)
		WD40 repeat	2509..2580	CDD:293791	22/76 (29%)
		WD40 repeat	2585..2621	CDD:293791	12/35 (34%)
nbeaa	NP_001013518.2	LamG	251..398	CDD:304605	36/233 (15%)
		DUF4704	468..739	CDD:292415	65/329 (20%)
		DUF1088	2017..2184	CDD:284000	29/180 (16%)
		PH_BEACH	2210..2307	CDD:291510	26/101 (26%)
		Beach	2339..2615	CDD:280327	156/278 (56%)
		WD40	<2687..2986	CDD:225201	83/298 (28%)
		WD40	2729..2986	CDD:295369	76/256 (30%)
		WD40 repeat	2776..2830	CDD:293791	22/76 (29%)
		WD40 repeat	2835..2870	CDD:293791	12/35 (34%)
		WD40 repeat	2875..2904	CDD:293791	6/32 (19%)
		WD40 repeat	2913..2951	CDD:293791	9/37 (24%)
		WD40 repeat	2959..2985	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810