DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43367 and rg

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	NP_001284879.1	Gene:	rg / 44531	FlyBaseID:	FBgn0266098	Length:	3785	Species:	Drosophila melanogaster

Alignment Length:	1500	Identity:	440/1500 - (29%)
Similarity:	652/1500 - (43%)	Gaps:	305/1500 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1389 EIQASVTEAATVIESEIKELAES---VSGAVVENANSLFSVIRQTTHDLQDTFESLTQGSSTDTA 1450
            :||.|..|...|.|:....||::   .||.....||       |||     |..:.|..::|...
  Fly  2445 QIQDSDYEIIVVDENNPSVLADNDSHSSGPPSIKAN-------QTT-----TIATTTTTTATTHI 2497

  Fly  1451 DGSQTPSIQREESLSSDTSSQSPHGPPK--------KSDSLESTSAFDFVADGDV------DTEE 1501
            :.:.|.:.......::....|.|..|||        ||            .|.||      .||.
  Fly  2498 NNNNTKTTTSNAPTATIKIQQQPLSPPKPLVPQKLPKS------------VDSDVGSLNMNSTEN 2550

  Fly  1502 QLVYLVSNTLFNIFWRGIPNDH------PQCWQERGQVLGCINLLALNNELITSHLSLRLRILEM 1560
            ::..:.|::...|      :||      .:.|.:       :||    ||             :.
  Fly  2551 EVPEVESSSEILI------DDHKPSHSNDESWTD-------VNL----NE-------------DA 2585

  Fly  1561 AVQAS------------------LFDLSEHGSQTLVNQENASHILRMVYELVVLGSNEDESKKCS 1607
            ||||:                  ..|.|.|..|    |:..:.|:....:...||.:|...|..|
  Fly  2586 AVQAASAGIVVGLVDNRGNVISDKHDPSHHNQQ----QQQQAGIIGQQQQHGSLGHSERGDKPDS 2646

  Fly  1608 ----TKLLDGVLALLDALMIFQQGSSDDWSDMIRLCLGLLLKCSHHPNPGIVAMATAKLHAILQS 1668
                .::.||            .|.:..... :....|..:..:..|.|..:.|   |..|::
  Fly  2647 EISVVRVPDG------------YGGAGSGGG-VNSGQGQGVPSNQRPRPEELPM---KAPALV-- 2693

  Fly  1669 RSTEDPAELSYLLYSINRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLDSTLPDLPST--- 1730
                  |:|.....|...:|...:|:.       |.||. .||.:..|.|     .|.|..|
  Fly  2694 ------AQLPLTTPSREASLTQKLEIA-------LGPVC-PLLREIMVDF-----APFLSKTLVG 2739

  Fly  1731 SSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQRDIELH----LWEPINRFWAECYEACKAAS 1791
            |.|.....:.:..:|.|...:.:|.::......:|..::.|    ..|.||.     ......|.
  Fly  2740 SHGQELLMEGKGLTTFKNSHSVVELVMLLCSQEWQNSLQKHAGLAFIELINE-----GRLLSHAM 2799

  Fly  1792 KQ---RATNQAE---NRRL---------FQQKIYMPWKVRQVEEM---QRLQAAALQHKTIDSHI 1838
            |.   |..|:||   ||..         |:.:.......|:.||.   ..:.||..:...|.|.:
  Fly  2800 KDHIVRVANEAEFILNRMRADDVLKHADFESQCAQTLLERREEERMCDHLITAARRRDNVIASRL 2864

  Fly  1839 RKRWKTAKRFLYGPRGPW-----------YTGEVDEE-FWKLSQHENVARMRLKLEPQLYPNKHE 1891
            .::   .:..:....|.|           ..|.|.:. :|||...|:.||.|.::......:.|.
  Fly  2865 LEK---VRNIMCNRHGAWGDSSSTSSGGAIVGAVQKSPYWKLDAWEDDARRRKRMVQNPRGSSHP 2926

  Fly  1892 NA---ANLRDNATSAYDTKEISEFDSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQQDVALEK 1953
            .|   |.|.:........:...||.:.|  ||.|...:...:.:|.::...||:.: :.|:.|..
  Fly  2927 QATLKAALENGGPEDAILQTRDEFHTQI--AVSRTHPSGQHNGELLDDAELLIEDR-ELDLDLTG 2988

  Fly  1954 LV-MSQDCELITLMTKVKGRIEVNQS-VFTFVDLSPP---TEDGSKYDF------RFSTNKIREV 2007
            .| :|....||.......|.:.:..: :|..||...|   ..||....:      ::..:::|.:
  Fly  2989 PVNISTKARLIAPGLVAPGTVSITSTEMFFEVDEEHPEFQKIDGEVLKYCDHLHGKWYFSEVRAI 3053

  Fly  2008 HLRKYNLRRSALEIFLVDQTSYFLNF----TTKTRNKVFTKI-VGLP--LPNILYGSGRSPAELL 2065
            ..|:|.|:..||||||..:||....|    |.|...|...:: ||:.  :|.....|..||.:|:
  Fly  3054 FSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRRASMMSPRQLM 3118

  Fly  2066 RASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSK 2130
            |.|.:||:|..||||||||||:|||||||:||||:|||:|||:|.:|.|..|||:.|.::|||||
  Fly  3119 RNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSK 3183

  Fly  2131 PIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFD 2195
            |||.:||...|....:|:|::  |..||.||||||||.:|..|::|:||||||::.:.||.|:||
  Fly  3184 PIGALNPSRRAYFEERYESWD--SDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFD 3246

  Fly  2196 VADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWAT 2260
            ..||.|.|:..:||....:.:||||||||:::.||...|.:.:.|||.: ....|||:.||.||.
  Fly  3247 YPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYRLGHRE-DGALVDDIELPPWAK 3310

  Fly  2261 TPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVE 2325
            :||||:.|:|.|||||:||..||.||||||||||:||:|..|.|||||.:|||:||||.:.:||.
  Fly  3311 SPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVM 3375

  Fly  2326 REAVEGMINNFGQVPSQLLREPHPRRLTQDETALKL--VRAELRRPDLTQFLDKVVQYYCELSTP 2388
            |||||..|.||||.|||||.||||.|    .:|:.|  :.......||.|.|    ::|     .
  Fly  3376 REAVENQIRNFGQTPSQLLMEPHPPR----SSAMHLSPMMFSAMPEDLCQML----KFY-----Q 3427

  Fly  2389 KDPIVYLSPPRSPPRSFLQLSPDVLVSISKSTILGCNSW-------------------------L 2428
            ..|::::|....|     |||...:|:::.......|.|                         |
  Fly  3428 NSPVIHISANTYP-----QLSLPSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSNQPL 3487

  Fly  2429 SFDKDQGFLLEIDAT--TANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYN 2491
            :.|.    :|.:..|  .:|..:|:.:...|....:..|..|..:.|.:.|.|.|.||||.||:.
  Fly  3488 TIDP----VLAVHGTNNNSNAASRRHLGDNFSQMLKIRSNCFVTTVDSRFLIACGFWDNSFRVFA 3548

  Fly  2492 LNKGKAVASVTRHLDIITCIALDNCG----SYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHAL 2552
            ....|.|..|..|..::||:|...|.    .|:.:||.|||.::|
  Fly  3549 TETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCTVLLW-------------------- 3593

  Fly  2553 TGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFV 2617
                |..|.||........|.|...|.||:.|::||.|..||.||||||.:|.|.::| ..|..:
  Fly  3594 ----HWNARTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHT-TFGDLL 3653

  Fly  2618 RTLKPIGCTESCVQISFVTLSYHGHIAFSALDDTSHSVHVYSINGCSLGSKYVSGRVTGLASASD 2682
            |:|.|.....|   ...:|:|..|   |..::....:|..|:|||..|..:..:..:..:..:.|
  Fly  3654 RSLDPPAEFHS---PELITMSREG---FIVINYDKGNVAAYTINGKKLRHETHNDNLQCMLLSRD 3712

  Fly  2683 --YLVVADDAGDITMSRLHGLKPVFDIP-LHVPIQTVVVTPGNTHILAPLRDGRLAVIAVQLPSG 2744
              ||:.|.|.|.:.:.|...|.|::..| .:..|:::.:|....::||.|..|.:.|..:..
  Fly  3713 GEYLMTAGDRGIVEVWRTFNLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHIDF--- 3774

  Fly  2745 GNKKH 2749
             |:.|
  Fly  3775 -NRWH 3778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605
		DUF4704	906..1162	CDD:292415
		DUF4800	1650..1899	CDD:292675	61/288 (21%)
		PH_BEACH	1952..2046	CDD:275391	27/109 (25%)
		Beach	2072..2351	CDD:280327	163/278 (59%)
		WD40	<2428..2734	CDD:225201	89/314 (28%)
		WD40 repeat	2465..2503	CDD:293791	15/37 (41%)
		WD40	2468..2687	CDD:295369	68/224 (30%)
		WD40 repeat	2509..2580	CDD:293791	18/74 (24%)
		WD40 repeat	2585..2621	CDD:293791	16/35 (46%)
rg	NP_001284879.1	LamG	210..358	CDD:304605
		DUF4704	634..918	CDD:292415
		MARCKS	1434..1751	CDD:280269
		DUF1088	2791..2972	CDD:284000	38/190 (20%)
		PH_BEACH	2996..3093	CDD:291510	25/96 (26%)
		Beach	3125..3401	CDD:280327	163/278 (59%)
		WD40 repeat	3524..3560	CDD:293791	14/35 (40%)
		WD40	<3526..3729	CDD:295369	70/233 (30%)
		WD40	<3530..3773	CDD:225201	81/273 (30%)
		WD40 repeat	3566..3617	CDD:293791	18/74 (24%)
		WD40 repeat	3622..3657	CDD:293791	16/35 (46%)
		WD40 repeat	3669..3699	CDD:293791	10/32 (31%)
		WD40 repeat	3704..3739	CDD:293791	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I226
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910