DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43367 and Nsmaf

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	NP_852054.2	Gene:	Nsmaf / 353233	RGDID:	727868	Length:	920	Species:	Rattus norvegicus

Alignment Length:	898	Identity:	256/898 - (28%)
Similarity:	395/898 - (43%)	Gaps:	168/898 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1868 LSQHENVARMRLKLEPQLYPNKHENAANLRDNATSAYDTKEISEFDS-----TIKNAVVRDFLAD 1927
            :.:|..||..:::.....|..:.|.:..:.|...:.......|..|.     .:..|:::..||
  Rat   115 IKEHNIVAPYKIERGKMEYVFQLEVSGKVEDVVETLLQLHRASCLDKLGDQMAMITAILQSRLA- 178

  Fly  1928 DESSQLEEELRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDG 1992
                      |...|....|.|: |||.|....|::|.:....|.:.:..:...|    .|....
  Rat   179 ----------RTSFDKNRFQSVS-EKLHMECKAEMVTPLVTNPGHVCITDTNLYF----QPLNGY 228

  Fly  1993 SKYDFRFSTNKIREVHLRKYNLRRSALEIFLVDQ---TSYFLNF-TTKTRNKVFTKIVGLPLPNI 2053
            .|...:.:...:|.::.|::.|....||:|..:.   :..:|.| ..:.|:.::..|......::
  Rat   229 PKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHV 293

  Fly  2054 LYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLD 2118
                    ||....|.:.| |....:||::||::||.:|.||.|||||||||||:::||:|..||
  Rat   294 --------AEHTAESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWVISDYSSPELD 349

  Fly  2119 LTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFT 2183
            |::|.:|||||||:|.:||:....:..:|....:     |||.||:|||:...||.||:|:.|
  Rat   350 LSNPATFRDLSKPVGALNPERLERLLTRYQEMPE-----PKFMYGSHYSSPGYVLFYLVRIAP-- 407

  Fly  2184 SLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFF-YFPEFLKNMNKFDLGHLQITK 2247
            ...:.||:||||.|||.|:||.:|||..:|...|.|||||||: ....||.|..|.|||..| ..
  Rat   408 EYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYDEDASFLINSLKLDLGKRQ-GG 471

  Fly  2248 EKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYE 2312
            :.||||.|||||::|::|:..::.||||.|||:|||.||||||||||||.:|..|.|||:..:||
  Rat   472 QMVDDVELPAWASSPQDFLQKNKDALESSYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYE 536

  Fly  2313 GAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDK 2377
            |.|||:.|.:|.::.|:...|..|||.|.||...|||||:|....:|.  :|......:|.
  Rat   537 GGVDLNSIEDPDDKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLS--QASSYNASMTD---- 595

  Fly  2378 VVQYYCELSTPKDPIVYLSPPRSPPRSFLQLSPDVLV---------------SISKSTILG---- 2423
                              ||......||..|:.:...               .|.|..:.|
  Rat   596 ------------------SPVSPGEESFEDLTEESKTLAWNNITKLQLHEQYKIHKEAVTGIAVS 642

  Fly  2424 CNSWLSFDKDQGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLR 2488
            ||....|...|...|::.:..:.:..|...|     |....|....:..|..::.:.  |||::.
  Rat   643 CNGSSVFTTSQDSTLKMFSKESKMLQRSISF-----SNMALSSCLLLPGDTTVISSS--WDNNVY 700

  Fly  2489 VYNLNKGKAVASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALT 2553
            .|::..|:...::..|.|.::.|...|  ..|.:.|.|.|..|||....:..|           |
  Rat   701 FYSIAFGRRQDTLMGHDDAVSKICWHN--DRLYSASWDSTVKVWSGVPAEMPG-----------T 752

  Fly  2554 GQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVR 2618
            .:.....:.:|.               ||.:::::.:.....|:|||:.:|.||::.|.....:.
  Rat   753 KRHQFDLLAELE---------------HDVSVNTINLNAVSTLLVSGTKEGLVNIWDLTTATLLH 802

  Fly  2619 TLKPIGCTESCVQISFVTLSYHGHIAFSALDDTSHSVHVYSINGCSLGSKYVSGRVTGLASASDY 2683
            .:       ||         :.|.:..:|....|..|....::||
  Rat   803 QI-------SC---------HSGTVCDAAFSPDSRHVLSTGVDGC-------------------- 831

  Fly  2684 LVVADDAGDITMSRLHGLKPVFDIPLHVPIQTVVVTPGNTHILAPLRDGRLAV 2736
            |.|.|....:.:|.:...:|          |...|..||: :|:..|.|.|.|
  Rat   832 LNVIDVQTGMLISSMASEEP----------QRCFVWDGNS-VLSGSRTGELLV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605
		DUF4704	906..1162	CDD:292415
		DUF4800	1650..1899	CDD:292675	5/30 (17%)
		PH_BEACH	1952..2046	CDD:275391	19/97 (20%)
		Beach	2072..2351	CDD:280327	143/279 (51%)
		WD40	<2428..2734	CDD:225201	57/305 (19%)
		WD40 repeat	2465..2503	CDD:293791	7/37 (19%)
		WD40	2468..2687	CDD:295369	39/218 (18%)
		WD40 repeat	2509..2580	CDD:293791	12/70 (17%)
		WD40 repeat	2585..2621	CDD:293791	8/35 (23%)
Nsmaf	NP_852054.2	PH-like	192..285	CDD:418428	19/96 (20%)
		Beach	304..575	CDD:396627	143/279 (51%)
		WD40	625..917	CDD:238121	64/331 (19%)
		WD40 repeat	636..673	CDD:293791	7/36 (19%)
		WD40 repeat	679..715	CDD:293791	7/37 (19%)
		WD40 repeat	720..764	CDD:293791	11/56 (20%)
		WD40 repeat	770..805	CDD:293791	8/41 (20%)
		WD40 repeat	811..848	CDD:293791	9/56 (16%)
		WD40 repeat	892..916	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820