DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43367 and NBEA

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:NP_001371941.1 Gene:NBEA / 26960 HGNCID:7648 Length:2967 Species:Homo sapiens


Alignment Length:3058 Identity:662/3058 - (21%)
Similarity:1053/3058 - (34%) Gaps:1088/3058 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 MLRLLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLTAESLAENCVQNLI 547
            |..||.......:.|...:.:.:|:....|.:|.|..   .:|:.|   ||...::.:.....|:
Human   121 MTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEV---GLIEQV---LLKMSAVDDMIADLLV 179

  Fly   548 KLIEELSKLSIVPAELKCIFSLLRQGTKFPQFKQLQQTLVVIALQSLRGSNSCAEFFSIEQ-PTD 611
            .::..|:..||...|||.:||:||..:.......::...|:..:....|.::   ||:... ...
Human   180 DMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDT---FFNFPGCSAA 241

  Fly   612 GILVPDIRNWTISGSYGFIFHILVRFNQLK--EQSNSRRMLLTLQTASGSGFEV-FVQPNGNVVV 673
            .|.:|.|..|....  ||..:...|.:.|.  .....:..|...:|:.|.|:.. ||   ||.::
Human   242 AIALPPIAKWPYQN--GFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFV---GNCLI 301

  Fly   674 AALTRREYLTSSTATKTLMDGQWHYLTVAITPPK----------RPFSYSQINIYVDFVQKLSAT 728
            .           |:.|:...|..|.:.....|.|          ..:..|:|..||:        
Human   302 V-----------TSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVN-------- 347

  Fly   729 LKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNY 793
                                    |::...|:|                                
Human   348 ------------------------GQLVSYGDM-------------------------------- 356

  Fly   794 FTLPMRTQTAFDPNVKNFPIGMQDTVFGEQT-CLNGHLGGVLLADPTTSLKTIF---DAGANFSS 854
             ...:.|..::|   |.| :|..:|....:. |  |.||.|.:.....:...||   ..|..:.|
Human   357 -AWHVNTNDSYD---KCF-LGSSETADANRVFC--GQLGAVYVFSEALNPAQIFAIHQLGPGYKS 414

  Fly   855 IF----SQDNDLLE----------LNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIVK 905
            .|    ..|..|.|          |.|...|.|...|.....|.:..|.......:::.|..:::
Human   415 TFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQ 479

  Fly   906 ---------IQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEM 961
                     |...|:|||||..:.|:..:|.. .|..|..:     |:..|              
Human   480 DVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDN-RQLNDSQV-----ETTVC-------------- 524

  Fly   962 LSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALMA 1026
                            |:.|..|..|.......|||:|..:...::|.:|::.       :.:..
Human   525 ----------------ATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKS-------SRVHI 566

  Fly  1027 THLLMES-------LQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRK 1084
            |..::|.       |.|  ...|..||..|..||:|:.|||.....::.|....||||.......
Human   567 TRAVLEQFLSFAKYLDG--LSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTAT 629

  Fly  1085 FFR--KRYG-VQFVLDVVRQYY----------STPDSI-----SDDDAKTIRATLFGIIKFYLQK 1131
            .:.  :|.| |..::..::.||          .||..:     |..:..::||.:...:|..:.|
Human   630 IYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILK 694

  Fly  1132 DVNIK--EVNSMITFLASVRQD------------------------------------------- 1151
            |..:|  |:.|::.:|.::.:|                                           
Human   695 DRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSE 759

  Fly  1152 VVLVEFLEMMTFYVR--GKNCKDQMV------------LLLH----------------------- 1179
            .:.|:.|:::.::::  |...|.:::            |:||                       
Human   760 SIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQ 824

  Fly  1180 -------EPQS-------------ANLLYN-------------FFVD--KSYSN----------- 1198
                   ||.|             |.||.|             |..|  |.:||           
Human   825 VVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQC 889

  Fly  1199 ---------------------EIQEA-----------AIRFISG---------LLATSRV----H 1218
                                 :|.|.           ||::..|         .:|.|:|    |
Human   890 SVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAH 954

  Fly  1219 QKYKQVLRLYDQTTEQ-------------SMFPGFFSFIT------------------------- 1245
            ::|  :.::|::...|             |...|..|..|                         
Human   955 KEY--LAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETD 1017

  Fly  1246 -PLSLSSTILF---HLVDEMLGLQPDYAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQS--- 1303
             |:|..:..|.   .:.|::|| ..|..|   ...||...||.|.::..|  ::.|.||...   
Human  1018 YPVSTDTRDLLMSTKVSDDILG-NSDRPG---SGVHVEVHDLLVDIKAEK--VEATEVKLDDMDL 1076

  Fly  1304 ------------------------TVAMAK-QTGWQESIARLLIRK------------------- 1324
                                    :.|:.| |.....|:.  :|:|                   
Human  1077 SPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVG--IIKKNEEKDNGPLITLADEKEDL 1139

  Fly  1325 PITSS-------PPDEEK-----------------RRSFGINLDVLL------------------ 1347
            |.:|:       |..|||                 :...|::.|:.|                  
Human  1140 PNSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTSSIIE 1204

  Fly  1348 ---------EDNSNFLAQADL------ITFSEQ------------------EIGLAQLQQQQQEE 1379
                     .|..:.:::.||      :.::|.                  :.|......::.::
Human  1205 EKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSIISDTERSDD 1269

  Fly  1380 LSDSGLILNEIQASVTEAAT--------------------------------------------- 1399
            ..:||..:.:||.:.|..|.                                             
Human  1270 GKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEF 1334

  Fly  1400 ---------------VIESEI----KELAESVSGAVVENANSLFSVIRQTTHDLQDTFESL---- 1441
                           .:|:::    ....:||...|..|.|.:|  :..|.|.:....:::    
Human  1335 KWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIF--VHNTIHLISQMVDNIIIAC 1397

  Fly  1442 -------------------------TQGSSTDT-----------------ADGSQTPSIQREESL 1464
                                     |||.|.:|                 |.......|:.|:::
Human  1398 GGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNM 1462

  Fly  1465 SS---------------------------DTSSQSPHGPPKKSDSLESTSA-------------- 1488
            ||                           |..::|.||..|..:..:|.:|              
Human  1463 SSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEVPQSVTATAASKTPLENVPGN 1527

  Fly  1489 ------------------FDFVADGDVDTEEQ-------LVYLVS-------------------- 1508
                              ...|...|||..:|       :||.:|                    
Human  1528 LSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETTRT 1592

  Fly  1509 ----------------NTLFNI-------------------------FWRGIPNDHPQCWQER-- 1530
                            :|:..|                         |::..|...|...:|:  
Human  1593 GSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKET 1657

  Fly  1531 ----------------------GQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHG 1573
                                  .||...:|...|........:|..|..|...|:.|...|:|:.
Human  1658 PTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENP 1722

  Fly  1574 SQTL--------VNQE---NASHILRMV----YELVVLGSN----EDESKKCSTKLL-------- 1611
            |:||        ::|.   |...||:.:    .|:...|..    .|.:.|..|:.:        
Human  1723 SETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSF 1787

  Fly  1612 ------------DGVLALLDA--------------------------LMIFQQGSSDDWSDMIRL 1638
                        .|.||:...                          .||...|:.|..|.    
Human  1788 DRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSS---- 1848

  Fly  1639 CLGLLLKCSHHPNPGIVAMATAKLHAILQSRS--TEDPAELSYLLYSINRALDNAIEVGNPEEYS 1701
                    |...:...|..||:|....:|:.:  .||.||...:...:.|||:....:.......
Human  1849 --------SSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVD 1905

  Fly  1702 FLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQR 1766
            |...:.:.||........::..:....|||     ..:..|...|::|:|.|           |:
Human  1906 FAPFLSRTLLGSHGQELLIEGLVCMKSSTS-----VVELVMLLCSQEWQNSI-----------QK 1954

  Fly  1767 DIELHLWEPINRFWAECY-----------EACKAASKQRATNQAENRRLFQQKIYMPWKVRQVEE 1820
            :..|...|.||.....|:           ||....::|||.:..::.....|........|:.|:
Human  1955 NAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEK 2019

  Fly  1821 MQRLQAAALQHKTIDSHIRKRWKTAK--RFLYGPRGPWYTGEVD----EEFWKLSQHENVARMRL 1879
            |.....:|.:|:   .|:.......|  ..|....|.|  |.|.    .:||:|...|:..|.|.
Human  2020 MCDHLISAAKHR---DHVTANQLKQKILNILTNKHGAW--GAVSHSQLHDFWRLDYWEDDLRRRR 2079

  Fly  1880 KLEPQLYPNKHENAANLRDNATSAYDTKE-ISEFDSTIKNAVVRDFLA---------DDESSQLE 1934
            :.....:.:.|..|..   .|...|.|:| :.:...|.::..:.:..|         ||..|.|:
Human  2080 RFVRNAFGSTHAEALL---KAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQ 2141

  Fly  1935 EELRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTF-VDLSPPTEDGS---KY 1995
            |:         :.|.....:|:|...:||..:...||.:.:..:...| ||     ||.|   |.
Human  2142 EK---------EIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVD-----EDDSAFKKI 2192

  Fly  1996 DF-----------RFSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFTTK-TRNKVFTKIVGL 2048
            |.           ::..::||.|..|:|.|:.:|||:|:.::||...||..: |..||   :..|
Human  2193 DTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKV---VYSL 2254

  Fly  2049 P---------LPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPV 2104
            |         ||.....|..:|.:|.::|.:||||..||||||||||:|||||||:||||:||||
Human  2255 PRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPV 2319

  Fly  2105 FPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNS 2169
            |||:|.:|.|:.||||.|.:|||||||||.:|||.......:|:::||...  |.:||.||||.:
Human  2320 FPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQS--PPYHYNTHYSTA 2382

  Fly  2170 AGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKN 2234
            ...|.:|:|:||||:..::...|:||..||.|.|:.::|:....:.:|||||||||:|.||...|
Human  2383 TSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVN 2447

  Fly  2235 MNKFDLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKA 2299
            .|.::|| ::..:..|:||.||.||..||:|:.|:|.|||||:||..||.||||||||||:||:|
Human  2448 SNGYNLG-VREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEA 2511

  Fly  2300 AEALNVFYYCSYEGAVDLDKITNPVERE---------------------AVEGMINNFGQVPSQL 2343
            ..|||||:|.:|||:|:||.||:||.||                     |:|..|.||||.||||
Human  2512 VRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEAQIQNFGQTPSQL 2576

  Fly  2344 LREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPP------ 2402
            |.||||.|    .:|:.|  ..|.:..| .|.|::.|         |.|:.|..|.:.|      
Human  2577 LIEPHPPR----SSAMHL--CFLPQSPL-MFKDQMQQ---------DVIMVLKFPSNSPVTHVAA 2625

  Fly  2403 RSFLQLSPDVLVSISKSTILGCNSW-----------LSFDKDQGFLLEIDATTANLK--NRKRIF 2454
            .:...|:...:|:::.|.:...|.|           .|.|:.....:|:|...||..  |:::|.
Human  2626 NTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQIT 2690

  Fly  2455 GPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALD----- 2514
            .....|.|.::..|.|:.|.:.:...|.||.|.|||:...||....|..|.|::||:|..     
Human  2691 DLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIG 2755

  Fly  2515 -NCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVL 2578
             :|  |:|:||||.|.::|                  ..:|:.|   |...|..:|..|.|..||
Human  2756 GDC--YIVSGSRDATLLLW------------------YWSGRHH---IIGDNPNSSDYPAPRAVL 2797

  Fly  2579 YGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTLSYHGH- 2642
            .|||..:..|::..||.||:||:.:|...|:|: .|..:|.|:.   .|:|:....:::|..|| 
Human  2798 TGHDHEVVCVSVCAELGLVISGAKEGPCLVHTI-TGDLLRALEG---PENCLFPRLISVSSEGHC 2858

  Fly  2643 IAFSALDDTSHSVHVYSINGCSLGSKYV--SGRVTGLASASDYLVVADDAGDITMSRLHGLKPVF 2705
            |.:......|:    :||||..|....:  |.|...|:|....||...|.|.:.:.:....|.::
Human  2859 IIYYERGRFSN----FSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLY 2919

  Fly  2706 DIP 2708
            ..|
Human  2920 IYP 2922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 18/119 (15%)
DUF4704 906..1162 CDD:292415 62/325 (19%)
DUF4800 1650..1899 CDD:292675 55/267 (21%)
PH_BEACH 1952..2046 CDD:275391 31/109 (28%)
Beach 2072..2351 CDD:280327 160/299 (54%)
WD40 <2428..2734 CDD:225201 84/292 (29%)
WD40 repeat 2465..2503 CDD:293791 13/37 (35%)
WD40 2468..2687 CDD:295369 70/227 (31%)
WD40 repeat 2509..2580 CDD:293791 21/76 (28%)
WD40 repeat 2585..2621 CDD:293791 12/35 (34%)
NBEANP_001371941.1 LamG 255..402 CDD:419873 36/233 (15%)
DUF4704 477..737 CDD:406270 60/304 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..995 4/23 (17%)
WD 1. /evidence=ECO:0000305 1326..1368 3/41 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1490..1531 7/40 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1651..1675 1/23 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1711..1731 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1860 5/30 (17%)
DUF1088 1966..2132 CDD:399463 33/173 (19%)
PH_BEACH 2158..2255 CDD:405526 29/104 (28%)
Beach 2287..2584 CDD:396627 160/299 (54%)
WD40 2698..2955 CDD:421866 75/256 (29%)
WD 2. /evidence=ECO:0000305 2739..2782 17/65 (26%)
WD40 repeat 2745..2799 CDD:293791 21/76 (28%)
WD 3. /evidence=ECO:0000305 2799..2839 15/40 (38%)
WD40 repeat 2804..2839 CDD:293791 12/35 (34%)
WD40 repeat 2844..2873 CDD:293791 7/32 (22%)
WD 4. /evidence=ECO:0000305 2881..2920 9/38 (24%)
WD40 repeat 2882..2920 CDD:293791 9/37 (24%)
WD 5. /evidence=ECO:0000305 2923..2962 662/3058 (22%)
WD40 repeat 2928..2954 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1787
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.