DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and Nbeal2

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:NP_899099.2 Gene:Nbeal2 / 235627 MGIID:2448554 Length:2750 Species:Mus musculus


Alignment Length:2913 Identity:926/2913 - (31%)
Similarity:1447/2913 - (49%) Gaps:379/2913 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IYNLWVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQPDSGPHLGRLPDELLPA 71
            :|.||:.|..:.|..:.:|::..||.::...:.|.......|      .::|..:..||.:.|.|
Mouse     7 LYELWLLYYAQKDLGYLQQWLKAFVGVFEKTISLSSLEPRRP------EEAGAEVPLLPLDALHA 65

  Fly    72 IGKFIIVARDVCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKPNLIAILSRVFKQ 136
            :.:             :|::..:::..:|:...:|:||:.:|:.:.......|.::|:|:.:..:
Mouse    66 LAE-------------QLDQDDLDQALLLLKLFIILCRNLENVEAGWGQVLVPRVLALLTVLMAE 117

  Fly   137 QMELPQSVPAISHLFSSFSAFL--EVMYDPYLTWRSFVRGQ---SADYSRLSYKPHSVHVEIVPF 196
            .....|..........:..|.|  |.::|||.|||..:.|:   |.:.|:..:.|.::..|...|
Mouse   118 LKGSSQESHGTQLENVALHALLLCEGLFDPYQTWRRQLTGEVISSKEKSKYKFPPAALPCEFGAF 182

  Fly   197 IYDCFQEEK------LIRYAEIGESLLNILGAVICGSQLQLKVQKSLNSTSTLTNRNTNALTTSS 255
            ..:..|:.:      |:|       |:::.||::.|.:                           
Mouse   183 FQENLQDAERLPPTLLLR-------LIHLFGAILAGGK--------------------------- 213

  Fly   256 LAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQW--ESANNLRRVALQCYALM--VIVLQKS 316
                           .||..|:...:|...:.::|.|  ..|.:.::|.|...||:  |.||..|
Mouse   214 ---------------ANGQMAVSAGSVQGLLGVVRGWGRGPAQDPQQVPLALRALVGAVHVLHAS 263

  Fly   317 SPEERQIDLVTLVQLYCDALQELLATKHFDSGDANFDITSDADQDVAIDMAALSSTVAAVKFFVT 381
            ....|..:|.||::.|...|            :|::..:..:..:.|:....:|...|.......
Mouse   264 RAPPRGPELRTLLEGYFHIL------------NADWPTSPSSSPEEALVTLRVSMLDAIPMMLAC 316

  Fly   382 GDAGVSEAVSDSN-----LLELLTNLPKL-------------IKPWHISH---SSSLCSTMEALA 425
            .|..|.:|...||     |:.|:.| .||             :..|.::.   ...|....:|:|
Mouse   317 EDRPVLQATFLSNNCFEHLIRLIQN-SKLYLQARAPPEGDSDLATWLLTEPDVQKVLDQDTDAIA 380

  Fly   426 I--------LARHSPQSASQLRQGERIERLFTSLQEYGSPTVELLDTCFMLGYDESEHFLLLP-- 480
            :        :...||.:....::....:.|...||.:|.||..||.....:.. |.:|.:..|  
Mouse   381 VHVVRVLTCIMSGSPSAKEVFKERIGYQHLQEVLQSHGPPTHRLLQELLNMAV-EGDHSMHPPPP 444

  Fly   481 ----EVMLRLLNWVPTLQERE-QLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLTAESLAE 540
                :.:|.|:.|:|.|...| :|.:...:...|.....::|....:.::..:...|.|..:|..
Mouse   445 IRNEQPVLVLMQWLPALPTAELRLFLAQRLWWLCDSCPASRTTCVQAGLVGYLLETLNTGTALGA 509

  Fly   541 NCVQNLIKLIEELSKLSIVPAELKCIFSLLR-------QGTKFPQFKQLQQTLVVIALQSL---R 595
            .|.:.|:.|::.|.::|:.|.||:   .|||       :.:.....|......|:.||..:   |
Mouse   510 RCQEQLLALLQALGRVSLRPLELR---RLLRPPPGLDSESSGNESQKARHAGAVIRALSGMARHR 571

  Fly   596 GSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRFNQLKEQSNS-------RRMLLTL 653
            |......:|.:.....||:||.::.|.   ..||.||..:.....:....|       |:.|.:.
Mouse   572 GPARALRYFDLTPSMAGIMVPPVQRWP---GAGFTFHAWLCLQSSEAVPTSAPSRPLQRKQLYSF 633

  Fly   654 QTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPKRPFSYSQINIY 718
            .|:||||||.|....|.:|||..||:||:|.:....:..|..||.:.:...|.:||||.:.:|::
Mouse   634 FTSSGSGFEAFFTAAGTLVVAVCTRKEYVTVNLPEVSFADSAWHCVAIVHVPGRRPFSQNLVNVF 698

  Fly   719 VDFVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGE--VAKTGNMPRSSSQESGSSGYKGMLPSL 781
            .|.....:...:..:::|||:.|.||:.      |.  ...|..:|.||.    |:......|||
Mouse   699 KDGHLVKTVPFRFPSLSEPFSSCCIGSA------GHRTTTTTTGLPASSV----STALAHTHPSL 753

  Fly   782 LERTLSANVSNYFTLPMRTQTAFDP---------NVKNFPIGMQDTVFGEQTCLNGHLGGVLL-- 835
               |.|.:|      |..|...:.|         :|.:...|.|||.:|..|.|.|.||.|.:  
Mouse   754 ---TRSQSV------PASTGLGWGPGLGTPLQEGSVSSTLAGTQDTRWGSPTSLEGELGAVAIFH 809

  Fly   836 -ADPTTSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQ 899
             |...::|:.:...|.|..:.|..:.:|.|..::.:..|:|.|..:..|.||.||....||:...
Mouse   810 EALQPSALRVLCSLGPNEPAPFKPEGELHEFGTKLLLHYSPQACKNNICLDLSPGHGLDGRLTGH 874

  Fly   900 HCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSS 964
            ..:...:::.:|.:||:..:||:|.|:..  |..:...|......| ..|..::...|...:|..
Mouse   875 RVETWDVKDVVNCVGGMGVLLPLLERVAV--QPQEAEAGPCETHDL-VGPELTSGRNTQGLLLPL 936

  Fly   965 NSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALMATHL 1029
            ...:|.:|.::.:|:||.:||.....|..|||.|:..:..||:|.:|::.|.|..|:|.||:..|
Mouse   937 GKSSEDRMERNAVAAFLLMLRNFLQNHTVNQESLVQCQGPAIIGALLRKVPSSAMDMNVLMSAQL 1001

  Fly  1030 LMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFRKRYGVQF 1094
            |||..   .|:.||.||..||.|::|:|.:|:...|.:.|||.||:|:|::..|:..||:|||||
Mouse  1002 LMEQA---AADGGGPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSMVREHRQKLRKKYGVQF 1063

  Fly  1095 VLDVVRQYYSTPDS--ISDDDAKTIRATLFGIIKFYLQKDVNIKEVNSMITFLASVRQDVVLVEF 1157
            :||.:|.:||....  ::.||.:|::.:|.|:::.:|.::.:::::..::.|||:...|..:|..
Mouse  1064 LLDALRTHYSPQRERPLAADDLRTVQTSLLGLVREFLVRNFSVEDMQVVLNFLAATGDDGQVVGT 1128

  Fly  1158 LEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQEAAIRFISGLLATSRVHQKYK 1222
            ||::...::|...:|.:...|.|..:..:|....|....:..:.:...:.:..|....|:.::.:
Mouse  1129 LELLLTLLQGSPVQDPLAAFLLELGNLEVLLALLVRPKSTPLLTDRVCKILRRLQQNERLPERNR 1193

  Fly  1223 QVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLGLQP--------DYAGLIFLVYHVS 1279
            |.:||:|...:     |..:.::..|:|..:...|....:|..|        :.:.|:.:|....
Mouse  1194 QRIRLHDCGLQ-----GLVASLSEESISPQLCQGLYKLFVGTVPQVVSPDCLNLSDLLAVVQLSL 1253

  Fly  1280 SCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPIT-SSPPDEEKRRSFGINL 1343
            ..||.|:|:|.::|....:.:......:|:|.|||:.:.||.:.:..| ||||            
Mouse  1254 QADLSVRLDICRQLFYLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATDSSPP------------ 1306

  Fly  1344 DVLLEDNSNFLAQADLITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESEIKEL 1408
                    .||.:..:    ..|:.|:....:...:.||                ..:.||    
Mouse  1307 --------RFLPELPI----SSELALSPPPTELPADSSD----------------VFLPSE---- 1339

  Fly  1409 AESVSGAVVENANSLFSVIRQTTHDLQDTFESLTQGSST--DTADGSQTPSIQREESLSSDTSSQ 1471
            :..........|.|.||    |..||.....|:..|::.  .:::|:.||:.|.......|....
Mouse  1340 SPCPDQDAFYQALSPFS----TPFDLGLERASIGSGNTAGGGSSNGTVTPASQPGTPSPLDGPRP 1400

  Fly  1472 SPHGPPKKSDS----LESTSAFDFVADGDVDT----------EEQLVYLVSNTLFNIFWRGIPND 1522
            .|....:.|.|    ||..|..:....|| ||          ||:|..|::|.||::.|||:...
Mouse  1401 FPTAQGRHSSSLSNVLEDGSLLEPNISGD-DTSNTSNPQQTPEEELCNLLTNVLFSVTWRGVEGS 1464

  Fly  1523 HPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVN-QENASHI 1586
            ....|:|||||...:..|..:..|:.....::..:|||.::::|.|:.|.....|.| .:.|..:
Mouse  1465 AEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMMLESALTDIKEAPPGGLANLSQQALWL 1529

  Fly  1587 LRMVYELVVLGSNEDESKKCSTKLLDGVLALLDALMIFQQ--GSSDDWSDM----IRLCLGLLLK 1645
            ||::.:. :........:..|.||.:||..|||.|..:..  .|:.|..:|    :||.||.:|.
Mouse  1530 LRLLQDF-LCAEGHGNQELWSEKLFEGVCNLLDRLGAWPHLANSTADLREMAQIGLRLVLGYILL 1593

  Fly  1646 CSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSINRALDNAI------------EVGNPE 1698
                .:|.:.|.|..|||.:||:.......|..|:|..:..||..|:            .|...|
Mouse  1594 ----EDPQLHAQAYVKLHTLLQTAVPTRREEACYVLSKLEAALSRALTTSSSETEHASTAVAASE 1654

  Fly  1699 EYSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDR 1763
            ..|:|:|:::.||::......|...||.||.|:..|.||.|||.:..:.:||:||::.|:|...:
Mouse  1655 RCSWLVPLVRTLLDRAYGPLGLQWGLPSLPPTNGSPTFFEDFQAFCATAEWRHFIDKQVQPTMSK 1719

  Fly  1764 YQRDIELHLWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWKVR-QVEEMQR---L 1824
            ::.|......:.::.||..||:...::.::...::.::||.|::.:..|.:.| :||.::.   |
Mouse  1720 FEMDTYAKSHDLMSGFWNACYDTLMSSGQRHQRDRIQSRRAFKELVLEPAQRRARVEGLRYASVL 1784

  Fly  1825 QAAALQHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKLEPQLYPNK 1889
            :..|.||.|...|    |....|.|..|.|.|.........||||..|..:||||||.|..:.:.
Mouse  1785 KQQAAQHSTALLH----WGALWRQLSSPCGAWALRIPPAPHWKLSSAETYSRMRLKLVPNHHFDP 1845

  Fly  1890 HENAANLRDNATSA--YDTKEISEFDSTIKNAVVRDFLADDESSQLEEE----LRQLIDTQAQQD 1948
            |..|:.||||...|  ..|:|.|...:..|.|.:.....:....||.||    |..|::..|:.|
Mouse  1846 HLEASALRDNLGEAPMTPTEETSLPLAVTKEAKISAPPEELPEEQLGEEDLAALESLMEEAAELD 1910

  Fly  1949 VALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSP---PTEDGSKYDFRFSTNKIREVHLR 2010
            ...||||:|.:|:|:|::..|.|.:|:......|.|.|.   .||:|..:|||....::||||||
Mouse  1911 EKREKLVLSAECQLVTVVAVVPGLLEITTQHVYFYDGSTERVETEEGIGHDFRRPLAQLREVHLR 1975

  Fly  2011 KYNLRRSALEIFLVDQTSYFLNFT-------------------------TKTRNKVFTKIVGLPL 2050
            ::||||||||:|.:||::|||||.                         |:.||:|::.::.|..
Mouse  1976 RFNLRRSALELFFIDQSNYFLNFPHKVAASSASSPCQAPRPQLYPIPSHTQLRNQVYSLLLRLRP 2040

  Fly  2051 PNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSD 2115
            |...|.|.|||.|:||||||||:|:.||||||||||.|||||||:||||||||||||:|.||.|.
Mouse  2041 PTQGYLSSRSPLEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSP 2105

  Fly  2116 VLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVE 2180
            ||||::|..|||||||||.:|||:...||.||:|||||:|.|.||||||||||:|||:|||:|||
Mouse  2106 VLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVE 2170

  Fly  2181 PFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQI 2245
            ||||||:.|||||||.:||||||:...|:..:::|.|||||||||||||:||:|.|.||||.||:
Mouse  2171 PFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQL 2235

  Fly  2246 TKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCS 2310
            |.|||.||:||.||.:||:||..||:||||||||.|||.||||||||||:||.|.|||||||||:
Mouse  2236 TNEKVGDVVLPPWAGSPEDFIQKHRQALESEYVSTHLHEWIDLIFGYKQRGPAAEEALNVFYYCT 2300

  Fly  2311 YEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFL 2375
            ||||||||.:.:..||:|:||:|:||||.|.|||:||||.||:.:|.|.:|.|.:...|.:.|.|
Mouse  2301 YEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPRLSAEEAANRLARLDTNSPSIFQNL 2365

  Fly  2376 DKVVQYYCELSTPKDPIVYLSPPRSPPRSFL-QLSPDVLVSISKSTILGCNSWLSFDK--DQGFL 2437
            :::..::.|:.:...|:|....|.....||: |.|.|:||::|.|.:||.::||.:|:  :..|.
Mouse  2366 NQLKAFFAEVVSEAVPLVLALVPHRQSHSFITQSSSDMLVTVSASGLLGTHTWLPYDRNINNYFT 2430

  Fly  2438 LEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVT 2502
            ...|.|..:.|.:|.:.||:.|.....:|..||:.|||||::||.||.||||.:|.:|:.:..::
Mouse  2431 FSKDPTMGSPKVQKLLSGPWVSDSGVSAQALAVAPDGKLLFSGGHWDGSLRVTSLPRGRLLNQLS 2495

  Fly  2503 RHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQ 2567
            |||||:||:|||.||.||::||||.||:||                  .|..||.|.|       
Mouse  2496 RHLDIVTCLALDTCGIYLISGSRDTTCMVW------------------RLLQQSGLSA------- 2535

  Fly  2568 NSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQI 2632
             ..:|||:.|||||..|:|.|||.||||:.||||.||||.::|::.||||..|:|.|.|.. ..|
Mouse  2536 -GLAPKPVQVLYGHVAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPPGATLP-GPI 2598

  Fly  2633 SFVTLSYHGHIAF--SALD----DTSHSVHVYSINGCSLGSKYVSGRVTGLASASDYLVVADDAG 2691
            |.:.|...|.|..  ||.:    ..::|:|:||:||....|..::.:.|.|..|.|::::.....
Mouse  2599 SHLALGAEGQIVVQSSACERPGAQVTYSLHLYSVNGRLRASVTLTEQPTALTVAEDFVLLGTAQC 2663

  Fly  2692 DITMSRLHGLKP-VFDIPLHVPIQTVVVTPGNTHILAPLRDGRLAVIAVQLPS 2743
            .:.:..|:.|:| |..:|:.||:.:|.||...:|:|..|.||:|.|:....||
Mouse  2664 SLHILHLNKLRPAVPPLPMKVPVHSVSVTKERSHVLVGLEDGKLIVVGAGQPS 2716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 36/115 (31%)
DUF4704 906..1162 CDD:292415 84/257 (33%)
DUF4800 1650..1899 CDD:292675 79/264 (30%)
PH_BEACH 1952..2046 CDD:275391 46/121 (38%)
Beach 2072..2351 CDD:280327 201/278 (72%)
WD40 <2428..2734 CDD:225201 122/314 (39%)
WD40 repeat 2465..2503 CDD:293791 18/37 (49%)
WD40 2468..2687 CDD:295369 96/224 (43%)
WD40 repeat 2509..2580 CDD:293791 27/70 (39%)
WD40 repeat 2585..2621 CDD:293791 21/35 (60%)
Nbeal2NP_899099.2 DUF4704 876..1125 CDD:292415 81/254 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1319..1340 5/40 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1363..1441 17/78 (22%)
DUF4800 1590..1856 CDD:292675 81/273 (30%)
PH_BEACH 1914..2039 CDD:275391 46/124 (37%)
Beach 2062..2341 CDD:280327 201/278 (72%)
WD 1 2382..2420 14/37 (38%)
WD 2 2444..2487 21/42 (50%)
WD40 <2459..2709 CDD:225201 113/276 (41%)
WD40 repeat 2459..2496 CDD:293791 18/36 (50%)
WD40 2460..>2614 CDD:295369 83/180 (46%)
WD 3 2490..2527 22/54 (41%)
WD40 repeat 2502..2547 CDD:293791 27/70 (39%)
WD 4 2540..2578 24/37 (65%)
WD40 repeat 2552..2588 CDD:293791 21/35 (60%)
WD 5 2585..2627 11/42 (26%)
WD40 repeat 2627..2666 CDD:293791 10/38 (26%)
WD 6 2635..2670 5/34 (15%)
WD 7 2678..2713 13/34 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 453 1.000 Domainoid score I502
eggNOG 1 0.900 - - E1_KOG1787
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1442 1.000 Inparanoid score I117
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47730
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 1 1.000 - - FOG0003051
OrthoInspector 1 1.000 - - otm44087
orthoMCL 1 0.900 - - OOG6_101577
Panther 1 1.100 - - LDO PTHR13743
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1767
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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