DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and NBEAL2

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_016861499.1 Gene:NBEAL2 / 23218 HGNCID:31928 Length:2782 Species:Homo sapiens


Alignment Length:2925 Identity:924/2925 - (31%)
Similarity:1427/2925 - (48%) Gaps:399/2925 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IYNLWVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQPDSGPHLGRLPDE---- 67
            :|.||:.|..:.|..:.:|::..||..::..:.|.          .::|       |.|:|    
Human     7 LYELWLLYYAQKDLGYLQQWLKAFVGAFKKSISLS----------SLEP-------RRPEEAGAE 54

  Fly    68 --LLPAIGKFIIVARDVCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKPNLIAIL 130
              ||| :.:..::|.       :|.:..:|:..:|:...:|:||:.:||.:.......|.::|:|
Human    55 VPLLP-LDELHVLAE-------QLHQADLEQALLLLKLFIILCRNLENIEAGRGQVLVPRVLALL 111

  Fly   131 SRVFKQQMELPQSVPAISHLFS-SFSAFL--EVMYDPYLTWRSFVRGQ---SADYSRLSYKPHSV 189
            :::..:....|......:.|.: :..|.|  |.::|||.|||....|:   |.:.|:..:.|.::
Human   112 TKLVAELKGCPPPQGRGTQLENVALHALLLCEGLFDPYQTWRRQRSGEVISSKEKSKYKFPPAAL 176

  Fly   190 HVEIVPFIYDCFQEEK------LIRYAEIGESLLNILGAVICGSQLQLKVQKSLNSTSTLTNRNT 248
            ..|...|..:..|...      |:|       |:::..||:.|.:                    
Human   177 PQEFSAFFQESLQNADHLPPILLLR-------LIHLFCAVLAGGK-------------------- 214

  Fly   249 NALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQWESANN----LRRVALQCYALM 309
                                  .||..|:...:|...:|::|.|.....    |..:||:.....
Human   215 ----------------------ENGQMAVSDGSVKGLLSVVRGWSRGPAPDPCLVPLALEALVGA 257

  Fly   310 VIVLQKSSPEERQIDLVTLVQLYCDAL------------QELLATKHFDSGDANFDITSDADQDV 362
            |.||..|....|..:|..|::.|...|            :|.|.|......||...:.:..|:.|
Human   258 VHVLHASRAPPRGPELRALLESYFHVLNADWPAGLSSGPEEALVTLRVSMLDAIPMMLACEDRPV 322

  Fly   363 AIDMAALSST--------VAAVKFFVTGDAGVSEAVSDSNLLELLTNLPKLIKPWHISHSSSLCS 419
             :....||:.        :...|.::...|   ....||:|...|...|.:.|.......:....
Human   323 -LQATFLSNNCFEHLTRLIQNSKLYLQSRA---PPEGDSDLATRLLTEPDVQKVLDQDTDAIAVH 383

  Fly   420 TMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSPTVELLDTCFMLGYDESEHFLLLP---- 480
            .:..|..:...||.:....::......|...||.:|.||..||.....:.. |.:|.:..|    
Human   384 VVRVLTCIMSDSPSAKEVFKERIGYPHLQEVLQSHGPPTHRLLQELLNMAV-EGDHSMCPPPPIR 447

  Fly   481 --EVMLRLLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLL----TAESLA 539
              :.:|.|..|:|:|...|.....:..|:...|:.......|   :...:.||||    |..:|.
Human   448 NEQPVLVLAQWLPSLPTAELRLFLAQRLRWLCDSCPASRATC---VQAGLVGCLLETLSTGLALE 509

  Fly   540 ENCVQNLIKLIEELSKLSIVPAELKCIFSLLR------------QGTKFPQFKQLQQTLVVIALQ 592
            ..|.:.|:.|::.|.::||.|.||:   .|||            :..|......:.:||..:|..
Human   510 ARCQEQLLALLQALGRVSIRPMELR---HLLRPRPGLDSEPGGAEAGKARHAGAVIRTLSGMARH 571

  Fly   593 SLRGSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRFNQLKEQSN-------SRRML 650
              :|......:|.:.....||:||.::.|.   ..||.||..:..:.:.....       .|:.|
Human   572 --QGPARALRYFDLTPSMAGIMVPPVQRWP---GPGFTFHAWLCLHPMDTAPTPAPTRPLQRKQL 631

  Fly   651 LTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPKRPFSYSQI 715
            .:..|:||||||.|....|.:|||..||:||||.|....:..|..||.:.:...|.:||||.:.:
Human   632 YSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTMSLPEVSFADSAWHCVAIVHVPGRRPFSQNLV 696

  Fly   716 NIYVDFVQKLSATLKVQAVNEPFTVCSIGA-----------VVAPPQPGEVAKTGNMPRSSSQES 769
            ::|.|.....:|.|:..:::|||:.|.||:           :..||.|..:|.|......|....
Human   697 HVYKDGHLVKTAPLRCPSLSEPFSSCCIGSAGYRTTTTTTGLPTPPVPATLAYTHPALTRSQSVP 761

  Fly   770 GSSGY---KGMLPSLLERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLG 831
            .|:|.   .|::..|.|.::.:.::                      |.|||.:|..|.|.|.||
Human   762 ASTGLGWGSGLVAPLQEGSIDSTLA----------------------GTQDTRWGSPTSLEGELG 804

  Fly   832 GVLL---ADPTTSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYP 893
            .|.:   |...|:|:|:...|.|.::.|..:.:|.||::|.:..|:|.|..:..|.||.|.....
Human   805 AVAIFHEALQATALRTLCTLGPNETAPFKPEGELHELSTRLLLHYSPQACKNNICLDLSPSHGLD 869

  Fly   894 GRINAQHCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTD 958
            ||:.....:...:::.:|.:||:.|:||:|.|:..  |..:...|......| ..|..::...|.
Human   870 GRLTGHRVETWDVKDVVNCVGGMGALLPLLERVAA--QPKEAEAGPAETHDL-VGPELTSGHNTQ 931

  Fly   959 WEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNA 1023
            ..:|.....:|.:|.::.:|:||.:||.....|..|||.|:..:..||:|.:|::.|....|:|.
Human   932 GLVLPLGKSSEERMERNAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNV 996

  Fly  1024 LMATHLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFRK 1088
            ||:..||||.:   .||..|.||..||.|::|:|.:|:...|.:.|||.||:|::::..|:..||
Human   997 LMSAQLLMEQV---AAEGSGPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSIVREHRQKLRK 1058

  Fly  1089 RYGVQFVLDVVRQYYSTPDS--ISDDDAKTIRATLFGIIKFYLQKDVNIKEV---NSMITFLASV 1148
            :|||||:||.:|.:||....  ::.||.:|::.:|.|:.:.:|.:.::..:|   .:|::|||:.
Human  1059 KYGVQFILDALRTHYSPQRERPLAADDLRTVQTSLLGLAREFLVRSLSADDVQVTQTMLSFLAAT 1123

  Fly  1149 RQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQEAAIRFISGLLA 1213
            ..|...|..|:::...:.|...::.:.:.|.||.:..:|....|.......:.:...:.:..|..
Human  1124 GDDGQAVGALDLLLALLHGSLVQESLAVFLLEPGNLEVLLALLVRPGSLPLLPDRVCKILRRLQQ 1188

  Fly  1214 TSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLGLQ-PDYAGLIFLVYH 1277
            ..|:.::.:|.|||     .:....|..:.:...::|..:...|....||.. .:.:.|:.:|..
Human  1189 NERLPERSRQRLRL-----RECGLQGLVACLPEGTVSPQLCQGLYKLFLGADCLNLSDLLAVVQL 1248

  Fly  1278 VSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITS-SPPDEEKRRSFGI 1341
            ....||.|:|:|.::|....:.:......:|:|.|||:.:.||.:.:..|: |||.......   
Human  1249 SLQADLSVRLDICRQLFHLIYGQPDVVRLLARQAGWQDVLTRLYVLEAATAGSPPPSSPESP--- 1310

  Fly  1342 NLDVLLEDNSNFLAQADLITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESEIK 1406
                                 :..:....:...:...|.||                ..:.||  
Human  1311 ---------------------TSPKPAPPKPPTESPAEPSD----------------VFLPSE-- 1336

  Fly  1407 ELAESVSGAVVENANSLFSVIRQ--TTHDLQDTFESLTQGSST--DTADGSQTPSIQREESLSSD 1467
                    |...:.:..:..:..  |..||.....|:..|::.  ..:.|:.||:.|.......|
Human  1337 --------APCPDPDGFYHALSPFCTPFDLGLERSSVGSGNTAGGGGSSGTLTPASQPGTPSPLD 1393

  Fly  1468 TSSQSPHGPPKKSDS----LESTSAFDFVADGDVDT----------EEQLVYLVSNTLFNIFWRG 1518
            .....|..|.:.|.|    ||..|..:....|| ||          ||:|..|::|.||::.|||
Human  1394 GPRPFPAAPGRHSSSLSNVLEDGSLPEPTISGD-DTSNTSNPQQTSEEELCNLLTNVLFSVTWRG 1457

  Fly  1519 IPNDHPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVN-QEN 1582
            :.......|:|||||...:..|..:..|:.....::..:|||.::::|.|:.|.....|.: .:.
Human  1458 VEGSDEAAWRERGQVFSVLTQLGASATLVRPPDCIKRSLLEMMLESALTDIKEAPVGVLASLTQQ 1522

  Fly  1583 ASHILRMVYELVVLGSNEDESKKCSTKLLDGVLALLDALMIFQQ--GSSDDWSDM----IRLCLG 1641
            |..:||::.:. :........:..|.||.:||.:|||.|..:..  ..:.|..:|    :||.||
Human  1523 ALWLLRLLQDF-LCAEGHGNQELWSEKLFEGVCSLLDRLGAWPHLANGTADLREMAQIGLRLVLG 1586

  Fly  1642 LLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSINRALDNAI----------EVGN 1696
            .:|.    .:|.:.|.|..:||.:||:.......|..|:|..:..||...:          |.|:
Human  1587 YILL----EDPQLHAQAYVRLHMLLQTAVPARREEACYVLSKLEAALGRVLNTSSLESATDEAGS 1647

  Fly  1697 P----------EEYSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRN 1751
            |          |..|:|:|:::.||::......|...||.||.|:..|.||.|||.:..:.:||:
Human  1648 PLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLGLQWGLPSLPPTNGSPTFFEDFQAFCATPEWRH 1712

  Fly  1752 FIERMVKPLYDRYQRDIELHLWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWKVR 1816
            ||::.|:|...:::.|......:.::.||..||:...::.::|...:|::||.||:.:..|.:.|
Human  1713 FIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRRAFQELVLEPAQRR 1777

  Fly  1817 QVEEMQRLQAAALQHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKL 1881
            ...|..|..|...|..|..|.....|....|.|..|.|.|...:.....||||..|..:||||||
Human  1778 ARLEGLRYTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKL 1842

  Fly  1882 EPQLYPNKHENAANLRDN--ATSAYDTKEISEFDSTIKNAVV--------RDFLADDESSQLEEE 1936
            .|..:.:.|..|:.||||  ......|:|.|...:..|.|.|        .|.|.:||.::||..
Human  1843 VPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDELAELETP 1907

  Fly  1937 LRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSP---PTEDGSKYDFR 1998
            :.     .|:.|...||||:|.:|:|:|::..|.|.:||......|.|.|.   .||:|..||||
Human  1908 ME-----AAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFYDGSTERVETEEGIGYDFR 1967

  Fly  1999 FSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFT-------------------------TKTR 2038
            ....::||||||::||||||||:|.:||.:|||||.                         |:.|
Human  1968 RPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVR 2032

  Fly  2039 NKVFTKIVGLPLPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYP 2103
            |:|::.::.|..|:..|.|.|||.|:||||||||:|:.||||||||||.|||||||:||||||||
Human  2033 NQVYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYP 2097

  Fly  2104 VFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSN 2168
            ||||:|.||.|..|||::|..|||||||||.:|||:...||.||:|||||:|.|.||||||||||
Human  2098 VFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSN 2162

  Fly  2169 SAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLK 2233
            :|||:|||:|||||||||:.|||||||.:||||||:...|:..:::|.|||||||||||||:||:
Human  2163 AAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLE 2227

  Fly  2234 NMNKFDLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPK 2298
            |.|.||||.||:|.|||.||:||.||::||:||..||:||||||||.|||.||||||||||:||.
Human  2228 NQNGFDLGCLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPA 2292

  Fly  2299 AAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVR 2363
            |.|||||||||:||||||||.:|:..||:|:||:|:||||.|.|||:||||.||:.:|.|.:|.|
Human  2293 AEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRLAR 2357

  Fly  2364 AELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPPRSFL-QLSPDVLVSISKSTILGCNSW 2427
            .:...|.:.|.||::..::.|:.:...|:|....|...|.||: |.|||:||::|.|.:||.:||
Human  2358 LDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSW 2422

  Fly  2428 LSFDKD--QGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVY 2490
            |.:|::  ..|....|.|..:.|.::.:.||:........|..||:.|||||::||.||.||||.
Human  2423 LPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVT 2487

  Fly  2491 NLNKGKAVASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQ 2555
            .|.:||.::.::.|||::||:|||.||.||::||||.||:||.:.  .|||.|.           
Human  2488 ALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLL--HQGGLSV----------- 2539

  Fly  2556 SHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTL 2620
                         ..:|||:.|||||..|:|.|||.||||:.||||.||||.::|::.||||..|
Human  2540 -------------GLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAAL 2591

  Fly  2621 KPIGCTESCVQISFVTLSYHGHIAF--SALD----DTSHSVHVYSINGCSLGSKYVSGRVTGLAS 2679
            :|:|.|.. ..|..:.|...|.|..  ||.:    ..::|:|:||:||....|..::.:.|.|..
Human  2592 RPLGATFP-GPIFHLALGSEGQIVVQSSAWERPGAQVTYSLHLYSVNGKLRASLPLAEQPTALTV 2655

  Fly  2680 ASDYLVVADDAGDITMSRLHGLKPVF-DIPLHVPIQTVVVTPGNTHILAPLRDGRLAVIAVQLPS 2743
            ..|::::......:.:.:|:.|.|.. .:|:.|.|::|.||...:|:|..|.||:|.|:....||
Human  2656 TEDFVLLGTAQCALHILQLNTLLPAAPPLPMKVAIRSVAVTKERSHVLVGLEDGKLIVVVAGQPS 2720

  Fly  2744  2743
            Human  2721  2720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 41/126 (33%)
DUF4704 906..1162 CDD:292415 84/260 (32%)
DUF4800 1650..1899 CDD:292675 80/268 (30%)
PH_BEACH 1952..2046 CDD:275391 48/121 (40%)
Beach 2072..2351 CDD:280327 201/278 (72%)
WD40 <2428..2734 CDD:225201 115/314 (37%)
WD40 repeat 2465..2503 CDD:293791 19/37 (51%)
WD40 2468..2687 CDD:295369 92/224 (41%)
WD40 repeat 2509..2580 CDD:293791 26/70 (37%)
WD40 repeat 2585..2621 CDD:293791 21/35 (60%)
NBEAL2XP_016861499.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 455 1.000 Domainoid score I504
eggNOG 1 0.900 - - E1_KOG1787
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1438 1.000 Inparanoid score I115
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47730
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 1 1.000 - - FOG0003051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101577
Panther 1 1.100 - - LDO PTHR13743
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.880

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