DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and wdfy-3

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:NP_001255658.1 Gene:wdfy-3 / 178220 WormBaseID:WBGene00007752 Length:3358 Species:Caenorhabditis elegans


Alignment Length:3468 Identity:719/3468 - (20%)
Similarity:1201/3468 - (34%) Gaps:1146/3468 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 QAENCPMWH-------EVQPDSGPHLGRLPDELLPAIGKFIIVARDV---------CETEGKLEE 91
            :|.||  |.       ||..|.         .:..|:.|::||.:.|         ..:....:.
 Worm   214 EANNC--WRKLCARLLEVIADK---------SITNAVIKYVIVKKCVRIFVKNLSSAPSNSHSDA 267

  Fly    92 QAIEEVAILVDCLV--------------------IVCRHF------DN---------ILSII--- 118
            |...|..|.:.|.:                    .|.:.|      ||         .:|::   
 Worm   268 QKTAESIICLSCFLKNSAYLTDQLLDEFYEADGYTVIKDFLLKSETDNEIVRNILLMAISLVNSG 332

  Fly   119 KYEYKPNLIAILSRVFKQQMELP----------QSVPAISHLF------SSFSAFLEVMYDPYLT 167
            |:|..|...:.|.::...|:.:|          .:...:.|:|      |:....:::::..|..
 Worm   333 KFEITPQYTSGLVQLPAFQLPIPAGNGLSVRNLNAFALLYHVFLESTSESTSCTVIDILHSIYTC 397

  Fly   168 WRSFVRGQSADY-------------SRLSYKPHSVHV---EIVPF-------------------- 196
                   ..|:|             .:|..|||:|.|   |::.|                    
 Worm   398 -------DPANYFILDKEYPLSIFIDQLERKPHAVRVKLLELIEFAVFQLSHIPCRELISLCVLL 455

  Fly   197 ---------------IYDCFQEEKLI--------RYAEIGESLLNILGAVI-------------- 224
                           :..||   |||        .:.|:|  ||:.|..:|              
 Worm   456 KTEISAGKTAMCTIIVQMCF---KLITVDAIIKDAFREVG--LLDALCFIIRRMFEMYEKNIQNA 515

  Fly   225 --------CGSQLQLKVQKSLNSTSTLT-----NRNTNALTTSSLAPCSGDGLLDCDNLRNGMKA 276
                    ..||.|||:  ||.:|..||     |.....|.|.    |.|..||           
 Worm   516 SFTVTSTSSRSQDQLKL--SLLTTDLLTIIIKNNTENGKLFTE----CFGAKLL----------- 563

  Fly   277 ICPATVSITMSILRQWESA----------------------NNLR-RVALQCYALMVIVL----- 313
                 :.|...:..:|.|:                      |.|: |:.::...:|..:|     
 Worm   564 -----IEIVCEVNEEWRSSLLQLVKQLLIVAPTDQYIMHLVNTLQDRIPIENLEVMFSLLKALLG 623

  Fly   314 ------------QKSSP-----------EERQIDL-----VTLVQLYCDALQ------------- 337
                        :||..           |:|..||     ..:.:..|..|:             
 Worm   624 VVRESHKVRIQFRKSGGFLALSALLLGLEKRFTDLHPAGDGRIPREQCQMLEFVHIIFKVFTLSM 688

  Fly   338 --ELLATKHF------DSGDANFDITSDADQDVAIDM----------AALSSTVAAVKFFVTGDA 384
              |....|:|      ||..:...:||..::...|.:          ..|:|.:||.......|.
 Worm   689 RFEPSNAKYFSTEITWDSITSLLRLTSIFNESTVISIEETEWKSLTHTDLASEIAACHEVFRLDD 753

  Fly   385 GVSEAVSDSNLLELLTNLPKLIKPWHISHSSSLCSTMEALAILARHSPQSASQLR---QGERIER 446
            .:...           |:||.: |::|.....:|..:..:|:  .:..:..|.:|   .|..:|.
 Worm   754 NIEAG-----------NVPKGM-PFNIYFGCYVCRLIFNMAL--DNYEKMTSDIRWNDDGASLEE 804

  Fly   447 LF----TSLQEYGSPTVELLDTCFMLGYDESEHFLLLPEVMLRLLNWVPTLQEREQLHVTSLVLK 507
            ..    :||..:....:.:|  |            |||.:....:.|....|     :..||:||
 Worm   805 SIVSWTSSLLVHPGAIISML--C------------LLPSISASSMKWTIAAQ-----YYVSLLLK 850

  Fly   508 GCTDNYRTKTVAC----GSHIIKAVCGCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFS 568
            ....:.|.:.:.|    ..|:::......||...:   .:|....|:|.||..|:.|.:|:   |
 Worm   851 AILKSERNQQIMCQVDMPKHLLRIAEKLFLTENHI---LLQPFYYLLERLSYQSLTPNQLR---S 909

  Fly   569 LLR---------------------------QGTKFPQFKQLQQTLVVIALQSLRGS--NSCAEFF 604
            .||                           :|...|    ||:...::::.:.|..  .:...|.
 Worm   910 FLRLDSPLCCRSLDDDEDDDDDSKIEIADNEGGPVP----LQRVKALVSMMTPRDQYIGTAPSFV 970

  Fly   605 SIEQPTDGI-------LVPDIRNWTISGSY----GFIFHILVRFNQLKEQSNSRR--MLLTL--- 653
            ..:...:|.       |.|..........:    ||.|...:..:.|.::.....  .|||:   
 Worm   971 EFDMSVEGFAALYLPSLAPMFSTTKAERIFPPLNGFSFCTWIYLDALSDKKADAHPIRLLTVTRA 1035

  Fly   654 --------------QTASGSGF---------------EVFVQPNGNVVVAALTRREYLTSSTATK 689
                          |||..:.|               |...||..::...|..:.:.|...|...
 Worm  1036 VAPPNSDPPSKKPSQTAHLACFQCQFSAFDRSLLISTEESDQPGADLEKTANFQTDKLIRITLAD 1100

  Fly   690 TLMDGQWHYLTVAITPPKRPFSYSQINIYVD----FVQK--------------LSATLKVQAV-- 734
            .:..|:|.:|.|...  :.....||:::|::    ..||              |:.|..|.||  
 Worm  1101 QVRCGEWFHLAVVFN--RSVLKSSQVSLYLNGRHISTQKLMYVAQNAGGAATQLAQTYSVNAVVG 1163

  Fly   735 ---------------------NEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGML 778
                                 .||.|..::.||| ..||..:   ||...:|:           .
 Worm  1164 TLPALRRPSRLRFRLASIFLAEEPMTAETVRAVV-QLQPHYI---GNYQTAST-----------A 1213

  Fly   779 PSLLER----TLSANVSNYFTL-PMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLGGVLLADP 838
            |...|.    :|||..:...|| .:||.           .|..|.     ..|:.|| |:...|.
 Worm  1214 PLFHEEKIVFSLSAAATQELTLAKIRTM-----------YGKMDA-----EILSQHL-GISPNDH 1261

  Fly   839 TTSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKI 903
            :|.|:.:.:                      ...:||||       ....||...|.:..:....
 Worm  1262 STPLRVLCN----------------------TISHAPGA-------GRTFGGVIVGYLGMRTFTP 1297

  Fly   904 VKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSSNSYT 968
            ..:...::||||.:::    :.||.:...::....|:  :||..|..........|.  ::.||.
 Worm  1298 RPVPSLLDSIGGFASV----YGLIAMAVDSEGLYASL--KSLVSAIRSQPRLLATWN--NNRSYQ 1354

  Fly   969 EWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIV-------GTMLQRCP----PSLFDVN 1022
                          :|..|..:    :.::|:|..:.:|       .|..:..|    ||.|:  
 Worm  1355 --------------ILAVLLED----KAKMLNSHIMHMVFNVTGTADTSREHAPTISNPSAFE-- 1399

  Fly  1023 ALMATHLL--MESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKF 1085
                 .||  ::..:|..:|....||:..| .::.|..:                     |:.:.
 Worm  1400 -----DLLCDLKVWKGAPSELHKMLLEHFY-ELITDHQL---------------------NNLQV 1437

  Fly  1086 FRKRYGVQFVLDVVRQYYSTPDSISDDDAKTIRATLFGIIKFYLQKDVNIKEV------------ 1138
            .||...:..:|.::   :..|..|.:.|     ..:|.:|...:|...:.:.:            
 Worm  1438 VRKSSLLSRILLII---HDEPTMIKNTD-----EIIFNLISAIMQPQCDSRSILKIGQSIAATLP 1494

  Fly  1139 --------NSMITFLASVRQDV-----------------------VLVEFLEMMTFYVRGKNCKD 1172
                    :|.:.|..|..|.:                       ::..||......|:.:.| |
 Worm  1495 TSESECYEDSHLPFHISEIQKLFIESSDPPPEALHQVYIRNRLLNIIANFLANSNTQVQQQMC-D 1558

  Fly  1173 QMV-----------------------------LLLHEPQSANLLYNFFVDKSYSNEIQEA--AIR 1206
            |:|                             |:|::|   :||..|....:....:.||  .:|
 Worm  1559 QLVRTLGFDWLFALMSPGVHSGTIYLALRILLLILNQP---SLLARFKEGSANGGWLSEADSVVR 1620

  Fly  1207 FISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGF--------------FSFITPLSL-------- 1249
            ..:.::....|......|....|...|.|...||              :.:...|||        
 Worm  1621 NRAAVVLGFSVSAHGGAVGSKIDINPELSNCGGFAALEHLMAAHADKPYPYYAMLSLLVGQPISA 1685

  Fly  1250 --------------------SSTILFHLVDE----MLGLQPDYAGLIFLVYHVSSCDLPVKLEIA 1290
                                |::.:|..::.    ...:.|.:|.:...:||.||...|..:...
 Worm  1686 LRFCDQFNMELVWTHVFGLNSTSSVFEAINSANFCFDAIIPLFAMIRTSIYHQSSIHQPWTVTNP 1750

  Fly  1291 KRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITSSPPDEEKRRSFGINLDVLLEDNSNFLA 1355
            ..::|......|::.|........|.|..|                      ...|:||.:....
 Worm  1751 STVVQMITFMYQNSPAFFNIAHTDEFILAL----------------------FSTLIEDTNAMGV 1793

  Fly  1356 QADLITFSEQEIG--------LAQLQQQQQEELSD--SGLILNEIQASVTEAATVIESEIKELAE 1410
            ::::.....|:.|        .|.|.|.....:.|  ..:..:.:|.:.::..|:|::.:..::|
 Worm  1794 KSEVANRRSQDGGGSPDAEYFQAFLAQPNVRIVMDLLKKICCDNLQVNTSKNDTIIDAILDNISE 1858

  Fly  1411 SVSGAVVENA---NSLFSVIRQTTHDLQDTFESLTQGSSTDTADGSQTPSIQREESLSSDTSSQS 1472
            |.:....:.|   :.|.||:..|.              .||....|..|...:.:::....:   
 Worm  1859 SGNTRKTQIACLTSLLHSVLEHTV--------------GTDLLSSSALPPNTQAQNIVQIVA--- 1906

  Fly  1473 PHGPPKKSDSLESTSAFDFVADGDVDTEEQLVYLVSNTLFNIFWRGIPNDHPQCWQERGQVLGC- 1536
                   :.||.|:.|.|...:|.|...|.:..|  :||:::                 ||:.. 
 Worm  1907 -------NISLLSSRAVDAFWNGLVFGSESMRML--STLYHL-----------------QVIASK 1945

  Fly  1537 -INLLALNNELITS-HLSLRLRIL-----EMAVQASLFDLSEHGSQTLVNQENASHILRMVYELV 1594
             :| .|:|.|.||. .:.:.|.||     .:.||.|:.|    ...|||::           ..:
 Worm  1946 KVN-KAVNAEPITGCIMRMTLFILSRPIDSVPVQLSVLD----ALSTLVSK-----------RYL 1994

  Fly  1595 VLGSNEDESKKCSTKLLDGVLALLDALMIFQQGSSDDWSDMIRLCLGLLLKCSHHPNPGIVAMAT 1659
            .|.|||.......|.|:..:....|.|..||..||.  ||:.|....:.: |:......::....
 Worm  1995 FLSSNEAWFFASLTHLIFMLSVTPDVLFQFQDNSSS--SDLDRTSAQVAM-CACRVWSDVICAKQ 2056

  Fly  1660 AKLHAILQSRSTED-PAELSYLLYSI----NRALDN---AIEVGNPEEYSFLMPVMKALLEKCRV 1716
            |.:....:.:|..| .|..:.|.:|.    .:.:|:   ||:.|........:.....:.::...
 Worm  2057 ALIEETFKKQSVTDINAARALLSHSAGVYWQQFVDSQLRAIQTGGSSAQGSAVTAKDIIQQQISS 2121

  Fly  1717 AFN-------------LDSTLPDLPSTSSGPVFFNDFQMYSTSKK----WR----NFIERMVKP- 1759
            .||             ..||...|||:.|...    ::..||.|:    |.    :.|:.:|:. 
 Worm  2122 KFNRVASGITRFAAKRSMSTTTALPSSGSVAA----WKSTSTDKQVIFMWLRVHVSLIKELVRAQ 2182

  Fly  1760 ---------------LYDRYQRDIEL----HLWEP-----INRFWAECYEACKAASKQRATNQAE 1800
                           |:|.:|.:.||    .:|.|     :.:|..:..|......:::.   ..
 Worm  2183 STRYTEWHAHVRKWCLHDWHQWEAELTRERGIWGPERASKLEKFKLDLTEGPTTRMRRKL---IP 2244

  Fly  1801 NRRLFQQKIYMPWKVRQVEEMQRLQAA-----------ALQH--KTIDSHI--RKRWKTAKRFLY 1850
            ||..:....:.|.......:.||.:.|           .|:|  :|:|:.|  .....||     
 Worm  2245 NRNFYHIYPFRPHLEAPSAKAQRAKVAISFDSKPYYETCLRHRRRTLDTRIIDSSNVSTA----- 2304

  Fly  1851 GPR-GPWYTGEVDEEFWKLSQHENVARM--RLKLEPQLYPNKHENAANLRDNATSAYDTKEISEF 1912
            .|. |...:..:...|..||..|..:.:  ||........|....:..|.:......:.||..|.
 Worm  2305 SPEDGSGSSNLLGYSFTDLSLSEINSSLIRRLSTTAPATSNVSGTSLELNEEECETSERKEDDES 2369

  Fly  1913 DSTIKN------------AVVRDFLADDESSQLEEELRQLIDTQA-----QQDVALEKLVMSQDC 1960
            .|:|..            :...:...:.:..:.:||.:...|.|.     :|...|..:..   |
 Worm  2370 ISSISEKTDSNGVQSSGPSTSSNTTKEAKKEEKKEEKKAGPDNQTLLRLLEQGEQLHSMFR---C 2431

  Fly  1961 ELITLMTKVKGRIEVNQSVFTFVD---------------LSPPTED---------------GSKY 1995
            ..|..:...:|.:...:..|..||               ||....|               .|:.
 Worm  2432 ARIQGLETAEGLLLFGRDHFYVVDGFTLLKTKEIRDLDFLSQEMHDPIVPYPATGATQPPKSSRL 2496

  Fly  1996 DFRFSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGLPLPNILYG---- 2056
            ..:||.|.|||||.|:|.|:..|||:|..|..:|.|.|..|.|::||.|:..:.: |:..|    
 Worm  2497 CSKFSYNMIREVHKRRYLLQPIALEVFSSDGRNYLLAFPKKIRDRVFDKLTSMAI-NLSSGGSDS 2560

  Fly  2057 ------------SGRSP---AELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFP 2106
                        :||..   :.|:....:||||::..||||:|||:|||:|||.||||||||:||
 Worm  2561 LGGQKANVAIETTGRGASLLSSLIGQQSVTQRWLSGNISNFQYLMHLNTLAGRCYNDLSQYPIFP 2625

  Fly  2107 WILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAG 2171
            |:||||||..||..:..:|||.|||:|..:|....:...::..::||||..|.:.||||||::..
 Worm  2626 WVLADYTSSQLDFNNISTFRDFSKPMGAQSPDRLEQFLKRFREWDDPSGETPPYMYGTHYSSAMI 2690

  Fly  2172 VLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTW-KLLMDNPNDVKELIPEFFYFPEFLKNM 2235
            |:.||:|:||||...:.||.|.||:|||.|||:...| ....:|..||||||||||..||...|.
 Worm  2691 VVSYLVRLEPFTQQFLSLQGGHFDLADRMFHSVGDAWTSASRNNMADVKELIPEFFTLPEMFTNT 2755

  Fly  2236 NKFDLGHLQITKEK---VDDVILPAWA-TTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKG 2296
            |.||||    .|:.   |:||:||||. ..|.|||.:||:||||:|||.|||.||||||||||.|
 Worm  2756 NHFDLG----VKQNGIHVNDVLLPAWCHGDPREFIRLHRQALESDYVSSHLHEWIDLIFGYKQNG 2816

  Fly  2297 PKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKL 2361
            .:|.:..|:|::..|||:||.::|.:|:.|.|..|.:|||||:|:||.::|||::      .:.:
 Worm  2817 EEAVKNSNLFHHLFYEGSVDFERIDDPLTRNATIGFVNNFGQIPTQLFKKPHPQK------KVNI 2875

  Fly  2362 VRAELRRPDLTQFLDKVVQYYC--ELSTPKDPIVYLSPPRSPPRSFLQLSPDVLVSISKSTI-LG 2423
            :......|.:|   ...:.|:.  .:|.|:.|...|   ||...|..|.....:|::.::.: :|
 Worm  2876 LEGFSNTPGVT---TSRLFYHAIHNMSAPQTPFKEL---RSAIGSIHQNDKIGVVALEQNKVFIG 2934

  Fly  2424 CNSWLSF------------DKDQGF----LLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVST 2472
            .|.::::            |.|:..    :.|:|..|.             ::....:.||..:|
 Worm  2935 TNRYITWGLPDRSVRMGQIDNDKSVCVHEMCEVDEMTC-------------AAAGDETTLFCGNT 2986

  Fly  2473 DGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSY--LVTGSRDCTCIVW--- 2532
            .|.:.    :|..:.:..::.|   ::.:..|.|.|||:.  :|.|:  ||:.|||.|.:||   
 Worm  2987 SGCIT----VWKVNNKPLSMKK---LSVLNGHSDAITCLV--SCQSHAVLVSASRDLTVLVWHLS 3042

  Fly  2533 ----------------SIQTNQQGG--GSTNNIPVHALTGQSHLQAITQLNTQN---SYSPKPLT 2576
                            ::..|...|  .:..:..:|..|....|.|:  |||.:   :..|:.:.
 Worm  3043 EMFLIRQLPKHPHAVLAVAVNDATGDIATACSTLLHVWTLNGELLAV--LNTCDVAPAIDPQQMI 3105

  Fly  2577 VLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTLSYHG 2641
            :..    |.|::..:...::::.|:.||.|.:|                  ||| :.....|...
 Worm  3106 ISL----AFSTMNEWDNDNVIMCGTSDGIVKIY------------------SCV-VFENDGSVSE 3147

  Fly  2642 HIAFSALDDTSHSVHVYSI---------------NGCSLGSKYVSGRVTGLASASDYLVVADDAG 2691
            |.|....:..|:..|..|.               :..:..|..|||  :|.||.:.....:..||
 Worm  3148 HPALENPNSNSNENHDRSAAIAARLEKQRKRLKNSSTTATSSSVSG--SGSASLTSPGPASPSAG 3210

  Fly  2692 DITMSRLHGLKPVFDIP----LHVPIQTVVVT-------PGNTH-----ILAPLRDGRLAVIA-- 2738
            ....:.:       |:.    :.|.:|...:|       |.|.|     .:||.||.|...:.  
 Worm  3211 GSRATNI-------DVGGAQFVRVLVQRTALTMHTAFNRPDNVHPAPITAIAPSRDHRSLYVGDG 3268

  Fly  2739 -------VQLPSGGNKKHSVLNV 2754
                   .....||...|.|.:|
 Worm  3269 IGRVWCWQSAEGGGRADHWVQDV 3291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 33/183 (18%)
DUF4704 906..1162 CDD:292415 47/311 (15%)
DUF4800 1650..1899 CDD:292675 56/320 (18%)
PH_BEACH 1952..2046 CDD:275391 34/123 (28%)
Beach 2072..2351 CDD:280327 152/283 (54%)
WD40 <2428..2734 CDD:225201 72/378 (19%)
WD40 repeat 2465..2503 CDD:293791 6/37 (16%)
WD40 2468..2687 CDD:295369 53/259 (20%)
WD40 repeat 2509..2580 CDD:293791 22/96 (23%)
WD40 repeat 2585..2621 CDD:293791 6/35 (17%)
wdfy-3NP_001255658.1 DUF4800 <2179..2260 CDD:292675 13/83 (16%)
PH_BEACH 2423..2550 CDD:275391 35/129 (27%)
Beach 2591..2871 CDD:280327 152/283 (54%)
WD40 <2945..3150 CDD:295369 48/251 (19%)
WD40 <2945..3149 CDD:225201 47/250 (19%)
WD40 repeat 2971..3010 CDD:293791 7/58 (12%)
WD40 repeat 3016..3052 CDD:293791 12/37 (32%)
WD40 repeat 3057..3091 CDD:293791 6/35 (17%)
FYVE_WDFY3 3285..3349 CDD:277259 3/7 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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