DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43367 and Lyst

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	XP_006516624.1	Gene:	Lyst / 17101	MGIID:	107448	Length:	3839	Species:	Mus musculus

Alignment Length:	3286	Identity:	674/3286 - (20%)
Similarity:	1148/3286 - (34%)	Gaps:	1112/3286 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 LNILGAVICGSQLQLKVQKSLNSTSTLTNRNTNALTTSSLAPCSGDGLLDCDNLRN--------- 272
            :|.:...:|.:.|.:..:...:..|...:.:|:...:::..|.|  .:|.|.:|.|
Mouse   894 INTINLFLCVAFLCVSKEADSDRESANESEDTSGYDSTASEPLS--HMLPCLSLENVVLPSPECL 956

  Fly   273 ----GMKAICPATVSITMSILRQWESANNLRRVALQCYALMVIVLQK---SSPEE---RQIDLVT 327
                .:.::|.....:.....:|:......:    .|:.|:.:::||   |..|:   ||.::..
Mouse   957 HHAADIWSMCRWIYMLNSVFQKQFHRLGGFQ----VCHELIFMIIQKLFRSHTEDQGRRQGEMSR 1017

  Fly   328 LVQLYCDALQELLATKHFDSGDANFDITSDADQDVAIDMAALSSTVAAVKFFVTGDAGVSEAVSD 392
                  :..|||:...:     ....:..|.....|.|:..|..:..:|:.|      .|:.|..
Mouse  1018 ------NENQELIRISY-----PELTLKGDVSSATAPDLGFLRKSADSVRGF------QSQPVLP 1065

  Fly   393 SNLLELLT--NLPKLIKPWHISHS-SSLCS--TMEALAILARHSPQSASQL------RQGERIER 446
            ::..:::.  ::|...|.:....| :||.|  .:|:|..:..||.::..|.      .||..:|.
Mouse  1066 TSAEQIVATESVPGERKAFMSQQSETSLQSIRLLESLLAICLHSARACQQKMELELPSQGLSVEN 1130

  Fly   447 LFTSLQEYGSPT----VELLDTCF------MLG----------------YDESEHFLLLPEVMLR 485
            :...|:|:.|.:    .||....|      .||                :...|..|..|.
Mouse  1131 ILCELREHLSQSKVAETELAKPLFDALLRVALGNHSADLGPGDAVTEKSHPSEEELLSQPG---- 1191

  Fly   486 LLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLT--AESLAENCVQNLIK 548
                 ...:|.|.....||.|.|..:.|...:.:....:.....|..|.  ||..:.:.|.|  .
Mouse  1192 -----DFSEEAEDSQCCSLKLLGEEEGYEADSESNPEDVDTQDDGVELNPEAEGFSGSIVSN--N 1249

  Fly   549 LIEEL---------------------------------SKLSIVPAELKCIFSLLRQGT------ 574
            |:|.|                                 |.|.||..:.|.|..|::|||
Mouse  1250 LLENLTHGEIIYPEICMLGLNLLSASKAKLDVLAHVFESFLKIVRQKEKNISLLIQQGTVKILLG 1314

  Fly   575 --------KFPQFKQLQQTLVVIALQSLRGSNSCAE-------FFSIEQPTDGILVPDIR----- 619
                    ....|:..|:.||.: |.||..|.:|:|       .|..:.|...||:..|.
Mouse  1315 GFLNILTQTNSDFQACQRVLVDL-LVSLMSSRTCSEDLTLLLRIFLEKSPCTEILLLGIHKIVES 1378

  Fly   620 NWTISGSYGFIFHIL----------------------------VRFNQLKEQSNSR----RMLLT 652
            ::|:|.|....|..|                            .|.::.|::::..    |:|.:
Mouse  1379 DFTMSPSQCLTFPFLHTPSLSNGVLSQKPPGILNSKALGLLRRARISRGKKEADRESFPYRLLSS 1443

  Fly   653 LQTAS--------------GSGFEVFVQPNGNVV---VAALTRREYLTSSTATKTLMD------- 693
            ...|.              ..||.|.:..|...:   .:|..|.:.:........|.|
Mouse  1444 WHIAPIHLPLLGQNCWPHLSEGFSVSLWFNVEYIHESESAAERGKRVKKRNKPSVLEDSSFEGAE 1508

  Fly   694 GQWHYLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEP------FTVCSIGAVVAPPQP 752
            |....:|.:|.|..|......|::    :...|..|.:|...:|      |.||.        ..
Mouse  1509 GDRPEVTESINPGDRLIEDGCIHL----ISLGSKALMIQVWADPHSGTFIFRVCM--------DS 1561

  Fly   753 GEVAKTGNMPRSSSQES-------------------GSSGYKGMLPSLLERTLSANVSNYFTLPM 798
            .:..|..::.:..|||:                   |.....|.:...:......:|...|.||.
Mouse  1562 NDDTKAVSLAQVESQENIFFPSKWQHLVLTYIQHPQGKKNVHGEISIWVSGQRKTDVILDFVLPR 1626

  Fly   799 RTQTAFDPNVKNFPIGMQDTVFGEQTCLNGH----------------LGGVLLAD----PTTSLK 843
            :|..:.|.| |.|             |:.||                ||.:||.:    .:....
Mouse  1627 KTSLSSDSN-KTF-------------CMIGHCLTSQEESLQLAGKWDLGNLLLFNGAKIGSQEAF 1677

  Fly   844 TIFDAGANFSSI-----------FSQ--DNDLL---ELNSRFV--------------------FC 872
            .::..|.|::||           :|:  :.|:|   |:...|:                    .|
Mouse  1678 FLYACGPNYTSIMPCKYGQPVIDYSKYINKDILRCDEIRDLFMTKKEVDVGLLIESLSVVYTTCC 1742

  Fly   873 YAPGAIWHGTCQDLIPGGKYPGRINAQ---------------------------HCKIVKIQETI 910
            .|...|:.       |..:..|::..|                           .||  .||..:
Mouse  1743 PAQYTIYE-------PVIRLKGQVKTQPSQRPFSSKEAQSILLEPSQLKGLQPTECK--AIQGIL 1798

  Fly   911 NSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSSNSYTEWKMLQH 975
            :.|||....:.:..|::.|.               ||..|.:.
Mouse  1799 HEIGGAGTFVFLFARVVELS---------------SCEETQAL---------------------- 1826

  Fly   976 PLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTML--QRCPPSLFDVNALMATHLLMESLQG-- 1036
            .|...|.|::|    .:...::|.:...|:::..:|  |:|         ::..|:|...|:|
Mouse  1827 ALRVILSLIKY----SQQRTQELENCNGLSMIHQVLVKQKC---------IVGFHILKTLLEGCC 1878

  Fly  1037 -----HKAEAGGQLLDA----------LYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFF 1086
                 |.:|.|...||.          |...::.|:.||::.:..:.......|..:|:.:.  .
Mouse  1879 GEEVIHVSEHGEFKLDVESHAIIQDVKLLQELLLDWKIWNKAEQGVWETLLAALEVLIRVEH--H 1941

  Fly  1087 RKRYGVQFVLD--VVRQYYSTPDSISDDDAKTIRATLFGIIKFYLQKDVNIKEVNSMITFLASVR 1149
            ::::.::.:|:  ||..:..|...:.:.....:.:         :.::|    ..|.:..:|.|.
Mouse  1942 QQQFNIKQLLNAHVVHHFLLTCQVLQEHREGQLTS---------MPREV----CRSFVKIIAEVL 1993

  Fly  1150 QDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQS-------ANLLYNFFVD-KSYSNEIQEAA-I 1205
            .....:|.|.::.          ..:|.:|.|.:       .|..::..:| |.:..::|..| :
Mouse  1994 GSPPDLELLTVIF----------NFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSLAYL 2048

  Fly  1206 RFIS-------------------------GLLATSRVHQKY-KQVLRLYDQTTEQSMFPGFFSFI 1244
            |..|                         |..:::.|.|:. .|::|    :.....||.:...|
Mouse  2049 RHSSSGGQAFPSPGFLVISPSAFTAAPPEGTSSSNIVPQRMAAQMVR----SRSLPAFPTYLPLI 2109

  Fly  1245 TPLSLSSTILFHLVDEMLGL---QPDYAGLIFLVY---------HVSSCDLPVKLEIAKRLLQ-- 1295
            ....|::::.|. ||::..:   .|:...|:...|         .:|||      |.||.:.:
Mouse  2110 RAQKLAASLGFS-VDKLQNIADANPEKQNLLGRPYALKTSKEEAFISSC------ESAKTVCEME 2167

  Fly  1296 -------------------------------------------------------TTFVKQQSTV 1305
                                                                   .:|.:.||||
Mouse  2168 ALLGAHASANGVSRGSPRFPRARVDHKDVGTEPRSDDDSPGDESYPRRPDNLKGLASFQRSQSTV 2232

  Fly  1306 -----AMAKQTG------WQESIARLLIR-KPITSSPPDEEKRRS-------------------- 1338
                 |...|.|      |...:.|.... :..|.||..|.....
Mouse  2233 ASLGLAFPSQNGSAVASRWPSLVDRNADDWENFTFSPAYEASYNRATSTHSVIEDCLIPICCGLY 2297

  Fly  1339 ---FGINL---DVLLEDNSNFLAQADLIT------------------------------------ 1361
               .|:.|   |.:|||..:.:.|||::.
Mouse  2298 ELLSGVLLVLPDAMLEDVMDRIIQADILLVLVNHPSPAIQQGVIKLLHAYINRASKEQKDKFLKN 2362

  Fly  1362 --FS------------------------------EQEIGLAQLQQQQ------------------ 1376
              ||                              ::|..|.:::..:
Mouse  2363 RGFSLLANQLYLHRGTQELLECFVEMFFGRPIGLDEEFDLEEVKHMELFQKWSVIPVLGLIETSL 2427

  Fly  1377 -----------------------QEELSDSGLI---------LNEIQASV-TEAATVIESEIKEL 1408
                                   .:.|.|:||:         ||.::.:: .....::..:|::|
Mouse  2428 YDNVLLHNALLLLLQVLNSCSKVADMLLDNGLLYVLCNTVAALNGLEKNIPVNEYKLLACDIQQL 2492

  Fly  1409 -------AESVSGA----VVENANSLFSVIRQTTHD-------------LQDTFESLTQGSSTDT 1449
                   |.|.||.    |:|:...|...:..:.:.             ||...|.:...::.|:
Mouse  2493 FIAVTIHACSSSGTQYFRVIEDLIVLLGYLHNSKNKRTQNMALALQLRVLQAALEFIRSTANHDS 2557

  Fly  1450 ADGSQTPSIQR------EESLSSD---TSSQSPHGPPKKSDSLESTSAFDFVADGDVD------- 1498
            .....:||..|      ..|::..   ..|.:|: ||::...........|.:..|.|
Mouse  2558 ESPVHSPSAHRHSVPPKRRSIAGSIPVKGSVTPY-PPRRHFGSYGQLPMPFFSPLDQDSPQLSPG 2621

  Fly  1499 -------------------TEEQLVYL---VSNTLFNIFWRGIPNDHPQ--CWQERGQVLGCINL 1539
                               ||..|:.:   .|:.|.::..|.:..:||.  ...|..|.|..:.:
Mouse  2622 CTTCAASPRAGSRKFPLAQTESLLMKMRSVASDELHSMMQRRMSQEHPSQASEAELAQRLQRLTI 2686

  Fly  1540 LALNNELITSHLSLRLRILEMAVQASLFDL----------SEHGSQTLVNQENASHILRMVYELV 1594
            ||:|            ||:...:.:.:.|:          ....|||.:::|:..|....||
Mouse  2687 LAVN------------RIIYQELNSDIIDILRTPENTSQSKTSVSQTEISEEDMHHEQPSVY--- 2736

  Fly  1595 VLGSNEDESKKCSTKLLDGVLALLDALMIFQQGSS------DDWSDMIRLC-------LGLLLKC 1646
                 ....|:..|.||||....:        |||      ..|:.::..|       ||.||
Mouse  2737 -----NPFQKEMLTYLLDGFKVCI--------GSSKTSVSKQQWTKILGSCKETLRDQLGRLL-- 2786

  Fly  1647 SHHPNPGIVAMATAKLHAILQSRSTED---------PAELSYLLYSINRALDNAIEVGNPEEY-- 1700
            :|..:|........::..|:...:.:|         |...:.|:..::..:.|..:..:.||.
Mouse  2787 AHILSPTHTVQERKQILEIVHEPAHQDILRDCLSPSPQHGAKLVLYLSELIHNHQDELSEEEMDT 2851

  Fly  1701 -SFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRY 1764
             ..||..:|....||         :|  ||..|.|                    .::|.:.:..
Mouse  2852 AELLMNALKLCGHKC---------IP--PSAPSKP--------------------ELIKIIREEQ 2885

  Fly  1765 QRDIELHLWEPINRFWAECYEACKAASK---QRATNQAENRRLFQQKIYMPWKVRQVEEMQR--L 1824
            ::                 ||:.::.||   |:..|. ..:.|||:   :.:|.:.:.::..  .
Mouse  2886 KK-----------------YESEESVSKGSWQKTVNN-NQQSLFQR---LDFKSKDISKIAADIT 2929

  Fly  1825 QAAAL----QHKTIDSHIR----------KRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVA 1875
            ||.:|    :.|.:..|||          :.|:...:.|...|..||........|:|...|...
Mouse  2930 QAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQECIQQLTHDRAVWYDPIYYPTSWQLDPTEGPN 2994

  Fly  1876 RMRLKLEPQLY---PNKH------ENAANLRDNATSAYDTKEISEFDSTIKNAVVRDFLADDESS 1931
            |.|.:|: :.|   |||:      ::...||...:..::.|..|.|.||:|:.      |..||.
Mouse  2995 RERRRLQ-RCYLTIPNKYLLRDRQKSEGVLRPPLSYLFEDKTHSSFSSTVKDK------AASESI 3052

  Fly  1932 QLEEELRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYD 1996
            ::.   |:.|.....::.|.|.|:  ..|.:..:.......:|.:       .|....|..|
Mouse  3053 RVN---RRCISVAPSRETAGELLL--GKCGMYFVEDNASDAVESS-------SLQGELEPAS--- 3102

  Fly  1997 FRFSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNF-TTKTRNKVFTKIVGLPLPNIL-YGSGR 2059
            |.::..:|:|||.|.:.||.:|:||||.:..:..|.| ..|.|:.|:..|:...|||:| ||:
Mouse  3103 FSWTYEEIKEVHRRWWQLRDNAVEIFLTNGRTLLLAFDNNKVRDDVYQSILTNNLPNLLEYGN-- 3165

  Fly  2060 SPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKS 2124
                   .:.||..|.:.:|:|||||.:||..||||:|||.||||||:||:||.|:.|||.||..
Mouse  3166 -------ITALTNLWYSGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILSDYVSETLDLNDPSI 3223

  Fly  2125 FRDLSKPIGCINPKNEAEVRGKYDSFE----------DPSGAIPKFHYGTHYSNSAGVLHYLLRV 2179
            :|:|||||.....:.|......|...|          ||...:..:|||:|||||..|||:|:|:
Mouse  3224 YRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRM 3288

  Fly  2180 EPFTSLHIDLQSGRFDVADRQFHSIPQTWKL-LMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHL 2243
            .|||.:.:..|...||:.||.|||...||:| ..::..|||||||||||.||||.|...||.|..
Mouse  3289 PPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVR 3353

  Fly  2244 QITKEKVDDVILPAWA-TTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFY 2307
            | ..|:|:.|.||.|| ..|..||.|||:||||::|||::.|||||:|||||||..:.:|:|||:
Mouse  3354 Q-NGERVNHVNLPPWARNDPRLFILIHRQALESDHVSQNICHWIDLVFGYKQKGKASVQAINVFH 3417

  Fly  2308 YCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRR-----------------LTQD 2355
            ..:|.| :|:..:.:||:|.|:|.||..:||.|.||....|..|                 |.|
Mouse  3418 PATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHTAHASRPGAKLNIEGELPAAVGLLVQ- 3480

  Fly  2356 ETALKLVR---AELRRPDLTQFLD--KVVQYYCELSTPKDPIVYLSPPRSPPRSFLQLSPD-VLV 2414
             .|.:..|   .|:..|....::.  |..:|....|.|. |:|..|.|.......||..|. .:.
Mouse  3481 -FAFRETREPVKEVTHPSPLSWIKGLKWGEYVGSPSAPV-PVVCFSQPHGERFGSLQALPTRAIC 3543

  Fly  2415 SISKSTILGCNSWLSFDKDQGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYA 2479
            .:|::..|    .::::|:||                     ..|....:.|..|:.:.|   ||
Mouse  3544 GLSRNFCL----LMTYNKEQG---------------------VRSMNNTNIQWSAILSWG---YA 3580

  Fly  2480 GGIWDNSLRVYNLNKGKA-------VASVTRHLDIITCIAL-DNCGSYLVTGSRDCTCIVWSIQT 2536
                ||.||:    |.|.       :.|..:| .:.:|..: |:|  .|.|||:   |.|.:..|
Mouse  3581 ----DNILRL----KSKQSEPPINFIQSSQQH-QVTSCAWVPDSC--QLFTGSK---CGVITAYT 3631

  Fly  2537 NQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGS 2601
            |:    .|::.|       |.::..:|::            ||||.:.|:.:.:.....:::|.|
Mouse  3632 NR----LTSSTP-------SEIEMESQMH------------LYGHTEEITGLCVCKPYSVMISVS 3673

  Fly  2602 LDGTVNVYTLQEGQFVRTL-------KPIGCTESCVQISFVTLSYHGHIAFSALDDTSHSVHVYS 2659
            .|||..|:.|....:|::|       ..:..:|:...|:.|..|..|          ...:.:::
Mouse  3674 RDGTCIVWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGG----------GSDLRLWT 3728

  Fly  2660 INGCSLGSKYVSGRVTGLASAS-----DYLVVAD--DAGDITMSRLHGLKPVFDIPL---HVPIQ 2714
            :||..:|..:....:..:|.::     ...|:|.  :.|.:.:.....||||.:|..   :.||.
Mouse  3729 VNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPII 3793

  Fly  2715 TVVVTPGNTHILAPLRDGRLAVIA--------VQLP 2742
            ::..:....|:.....:|  .|||        |:||
Mouse  3794 SLTFSCDGHHLYTANSEG--TVIAWCRKDQQRVKLP 3827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605	24/142 (17%)
		DUF4704	906..1162	CDD:292415	44/276 (16%)
		DUF4800	1650..1899	CDD:292675	53/288 (18%)
		PH_BEACH	1952..2046	CDD:275391	25/94 (27%)
		Beach	2072..2351	CDD:280327	142/290 (49%)
		WD40	<2428..2734	CDD:225201	67/330 (20%)
		WD40 repeat	2465..2503	CDD:293791	12/44 (27%)
		WD40	2468..2687	CDD:295369	51/238 (21%)
		WD40 repeat	2509..2580	CDD:293791	16/71 (23%)
		WD40 repeat	2585..2621	CDD:293791	10/42 (24%)
Lyst	XP_006516624.1	PH_BEACH	3058..3153	CDD:373333	27/106 (25%)
		Beach	3170..3460	CDD:214982	143/291 (49%)
		WD40	3515..3816	CDD:392136	80/378 (21%)
		WD40 repeat	3607..3652	CDD:293791	16/72 (22%)
		WD40 repeat	3657..3693	CDD:293791	9/35 (26%)
		WD40 repeat	3700..3733	CDD:293791	7/42 (17%)
		WD40 repeat	3743..3784	CDD:293791	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820