Protein Alignment CG43367 and nbeal1

DIOPT Version :10

• Sequence 1: NP_001189048.2
• Gene: CG43367 / 38505
• FlyBaseID: FBgn0263110
• Length: 2754
• Species: Drosophila melanogaster
• Sequence 2: XP_002937765.2
• Gene: nbeal1 / 100494980
• XenbaseID: XB-GENE-990549
• Length: 2716
• Species: Xenopus tropicalis
• Alignment Length: 2890
• Identity: 999/2890 - (34%)
• Similarity: 1535/2890 - (53%)
• Gaps: 354/2890 - (12%)

  Fly     1 MDNKKDIYNLWVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQPDSGPHLGRLP 65
            |.:::.:|.||:.|..|.|..:.|.::..||:.:...|.:||  :..|...:.:|   |.|..||
 Frog     1 MASRERLYELWMLYCNKKDPDYLRLWLDSFVSGYEQFLDVDF--DELPTRIDDEP---PGLSLLP 60

  Fly    66 DELLPAIGKFIIVARDVCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKPNLIAIL 130
            |.:|..:...::..  |.:|...:||:......:||...:|:||:..|:..|....| .|.:..:
 Frog    61 DHILQVLRLQLLYC--VQKTADGMEEEQQTLSLLLVKFFIIICRNLSNVEEIGCCSY-INHVITM 122

  Fly   131 SRVFKQQ----------MELPQSVPAISHLFSSFSAFLEVMYDPYLTWRSFVRGQ---SADYSRL 182
            :.::.||          |:...:...:.|..    .|.|.:||||..||..:.|:   ..:.||.
 Frog   123 TTLYVQQLKSNTKEKELMDQSSTEEFVRHAL----VFCESLYDPYRNWRQIIAGKIICPVEKSRQ 183

  Fly   183 SYKPHSVHVEIVPFIYDCFQEEKLIRYAEIGES----LLNILGAVICGSQLQLKVQKSLNSTSTL 243
            .||..|:.||.:||.|.||||.:.::     ||    ||::.|:::.|||
 Frog   184 KYKAASLTVEFIPFFYQCFQESEHLK-----ESLKCCLLHLFGSILSGSQ--------------- 228

  Fly   244 TNRNTNALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQWESANN--------LRR 300
                                       ||.::||.|||:.:.|.||...::.|:        ...
 Frog   229 ---------------------------RNALQAISPATIEVLMRILADCDTWNDGDTGEVSRKAE 266

  Fly   301 VALQCYALMVIVLQKSSPEERQIDLVTLVQLYC-------DALQELLATKHFDSGDANFDITSDA 358
            :.|:|...::.:|..||.::||:::.|:::.|.       .||.....::|::    |..||
 Frog   267 LTLKCLTEVIHILLVSSSDQRQVEISTILENYFKLLNSDHSALSSQRRSRHWE----NRFIT--- 324

  Fly   359 DQDVAIDMAALSSTVAAVKFFVTGDAGVSEAV-SDSN----LLELLTNLPKLIKPWHISHSSS-- 416
               :.|.|....:.:...|     |..|.:|: .:||    |:.||.|...|:...:.....|
 Frog   325 ---LQIKMLTCMTDMLNCK-----DRPVLQAIFLNSNCFEHLIRLLQNCRLLLNANYRGAEKSEK 381

  Fly   417 -----------------------LCSTMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSPT 458
                                   ..:|::||..:...||.:....::..........|:..|.||
 Frog   382 ELVNKLLTEMNENQVFQERLDRLSVTTIQALTAVKHKSPSAKEVFKERIGYAHFLDVLKSLGQPT 446

  Fly   459 VELLDTCFMLGYDESEH----FLLLPEV--MLRLLNWVPTLQERE-QLHVTSLVLKGCTDNYRTK 516
            ..||:....:.. |.:|    .|.:..|  :|.|:.|:|.:|..: |:.::..:.:.|..|.:::
 Frog   447 RLLLEELLNMAV-EGDHNIVGILGISNVQPLLLLIQWLPEIQSHDLQIFISEWLKRICCINKQSR 510

  Fly   517 TVACGSHIIKAVCGCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLRQGTKFPQFKQ 581
            |:...::::..:...|.:..||...|.:|||.|:..|...|:...||..:.||||  ||  :.||
 Frog   511 TMCVNANMVIRIIETLNSHYSLHRACAENLIGLLGSLGSQSMSSEELFHLLSLLR--TK--EHKQ 571

  Fly   582 -----LQQTLVVIALQSLRGSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVR---FN 638
                 :..|..::|:...:|..|..::|::.....||.||.::.|..|....|.:..|.:   |:
 Frog   572 SHPYVIPVTRALLAITRKQGLCSALQYFNLSHSLAGIAVPTVQKWPGSAFSFFAWLCLDQDQSFS 636

  Fly   639 QLKEQSNSRRMLLTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAI 703
            .:......|:.|.:..|:||:|||.|:..:|.:|||..|::||.|.........|..||.:|:..
 Frog   637 AVSSSGTKRKQLYSFFTSSGTGFEAFITSSGVLVVAVCTKKEYATVMLPDHCFCDSLWHNVTIVH 701

  Fly   704 TPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGAV----------------VAPPQP 752
            .|.||||..|.:.|||:..||.||.||..::||.||.|.||:.                ::||..
 Frog   702 VPGKRPFGQSFVYIYVNGQQKASAPLKFPSMNEAFTSCCIGSAGQRTNTPPPSQIPDPPISPPSA 766

  Fly   753 GEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQD 817
            |.....|.: .||...||:.|                         :|    |...|....|.||
 Frog   767 GTRTSLGGI-LSSPSWSGTHG-------------------------KT----DGVTKLISAGTQD 801

  Fly   818 TVFGEQTCLNGHLGGVLLAD---PTTSLKTIFDAGANFSSIF-SQDNDLLELNSRFVFCYAPGAI 878
            :.:|..|.|.||||.||:..   ....:||::.||.|..|:: ||:::|.:|.::.:..|.|.|.
 Frog   802 SEWGSPTSLEGHLGSVLIFHDVLQAAQVKTLYLAGPNSLSLWKSQESELTDLPTKLLLYYTPKAC 866

  Fly   879 WHGTCQDLIPGGKYPGRINAQHCKIVK--IQETINSIGGISAILPMLHRLITLDQTTDISIGSVS 941
            .:..|.|| ......||:...  |:|.  |::.||.|||::::.|:|.::..|::
 Frog   867 KNPICLDL-SSNVLHGRLTGN--KVVNWDIKDMINCIGGLNSLFPLLEQISYLNE---------- 918

  Fly   942 EESLSCAPTPS----AEEFT----DWEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQL 998
               |.|..|.|    .|..|    |:.:|||...:|.::.::.:|:|:.|:::|...|..|||.|
 Frog   919 ---LPCEKTDSCVTATEHLTPIEGDFVVLSSTKASEARLEKNIVATFILLIKHLIQRHPINQEVL 980

  Fly   999 LSSECLAIVGTMLQRCPPSLFDVNALMATHLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRL 1063
            ..|..:|.:|.:||:...:|.|||.|||..||:|.:   ..|....||..:|.:::|||.||:|.
 Frog   981 TYSHGVATLGVLLQKVSGNLMDVNVLMAVQLLIEQV---SVEKNTLLLQQMYQYLLFDFRIWNRG 1042

  Fly  1064 QFQITLGHAQYLSAMIKNDRKFFRKRYGVQFVLDVVRQYYSTPDSISDDDAKTIRATLFGIIKFY 1128
            .|...:||.||:|.:||:.||.|||:||:||:||.:|.|||..::::.||..|||.:|||:||::
 Frog  1043 DFPFRIGHIQYVSTIIKDSRKLFRKKYGIQFLLDTIRIYYSKENALAADDLTTIRTSLFGLIKYF 1107

  Fly  1129 LQKDVNIKEVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVD 1193
            |.|....:|:.|:|.::|::..:..:...||::...:.|....||:.|||.||.||::||...::
 Frog  1108 LSKGGAPEEIQSIIGYIAAITDEEQIYGILEIILHLLNGSPVLDQLFLLLFEPGSADMLYALLLN 1172

  Fly  1194 KSYSNEIQEAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLV 1258
            :.||::::|...:....:|..::|::|.||.:||     .:..:.|....:...|:|:.::..|:
 Frog  1173 QRYSDKLKETVFKIFEQMLKCNKVYEKSKQRIRL-----REVGYSGLGLLLNDSSISTVLIKGLL 1232

  Fly  1259 DEMLGLQP-DYAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLI 1322
            :::|.... :|..|:.:|:..:..||.|::.:.:::||....:..:...:.:|.||||::.|..:
 Frog  1233 NQILTADTINYKDLLAVVHLSTRADLTVRVAVCRKILQLLQFQHDAAFQVCQQVGWQETLVRFFL 1297

  Fly  1323 RKPITSSPPDEEKRRSFGINLDVLLEDNSNFLAQ-ADLITFSEQEIGLAQLQQQQQEEL---SDS 1383
            ::.                     ||..|||.|. .|.|...||.....:.|:|..||:   ...
 Frog  1298 KEN---------------------LECKSNFRASCTDSIKEDEQNAVSEETQKQSSEEVVMDQAD 1341

  Fly  1384 GLILNEIQASVTEAATVIESEIKELAES--VSGAVVENANSLFSVIRQTTHDLQDTFESLTQGSS 1446
            |..||..|.:     :....|.|.|..|  .|.|::::..|:||   :..:.::|.........|
 Frog  1342 GCTLNNNQYN-----SYFPEESKSLDSSNQSSCALLDDEESIFS---EAQYKVEDQGNDWPSDHS 1398

  Fly  1447 TDTADGSQTPSIQREESL-SSDTSSQSP---------HGPPKKSDSLESTSAFDFVA-----DGD 1496
            ..|.|.:...:..||..: .|..|:.||         :...|.|:||::....|.::     :..
 Frog  1399 HLTLDLTPFDAGFRENQIPGSLPSTPSPVENSKQFVMNQSDKDSNSLKNVFFRDDLSLSVNMESR 1463

  Fly  1497 VDTEEQLVYLVSNTLFNIFWRGIPNDHPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMA 1561
            .|.||:||.||::.|..:.|:|:.......|.||||:...:..|..::.|:.|...::|.:||..
 Frog  1464 EDCEEELVQLVTDILLCLMWKGLDKSDSATWIERGQIFSALTCLESSSMLLRSSDEIKLNLLEKM 1528

  Fly  1562 VQASLFDLSEHGSQTLVNQENASHILRMVYELVVLGSNEDESKK----CSTKLLDGVLALLDALM 1622
            .:.::.:..|..||. :..|||..:|.:|.:.:     :.|..|    .:.|||:.::.|:|.:.
 Frog  1529 PEWAVTENRESKSQP-IYCENAKRLLHIVQDFL-----QTEGLKNPVLWTEKLLEEIVTLMDGIS 1587

  Fly  1623 IFQQG--SSDDWSDM-IRLCLGLLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSI 1684
            ::...  .|:..|.: .||.||.:.:    .|..:.|||.|||:.:||::..|:..|..|||..:
 Frog  1588 VWYSSGPESESLSQLEFRLLLGFIAQ----DNLQVCAMAAAKLNTLLQTKVIENQEEACYLLGKL 1648

  Fly  1685 NRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKW 1749
            ...|..:|: ...|.||||:|:::.|:.|......:...||.||.|:..|..|.|||.|..|.:|
 Frog  1649 EGILGKSIK-EKTETYSFLIPIVRTLVSKIYQLLFMHLHLPSLPITNGNPSLFEDFQEYCNSDEW 1712

  Fly  1750 RNFIERMVKPLYDRYQRDIELHLWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWK 1814
            |.||::.:.....:|:.|......|.:..:|.|||||......:|...:.|::..|::....|:.
 Frog  1713 RIFIDKYIILYMKQYEVDTFGKCHEQMATYWKECYEAQMVNMHKRERERGESKLKFKEFFLEPFN 1777

  Fly  1815 VRQVEEMQRLQAAALQHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRL 1879
            .:..:|..|......|..:..:...::||.|:|:|:..||||...:.:.::||||..||.:||||
 Frog  1778 RKTRQENSRYNNMLKQVNSQYTATLRQWKAAQRYLFCERGPWADRKENWQYWKLSTVENYSRMRL 1842

  Fly  1880 KLEPQLYPNKHENAANLRDNATSAYDTKEISEFDSTIKNAVVRDFLADDESSQLE--EELRQLID 1942
            ||...|..:.|..|:.|||| .....|:..||  |.:..|..:..::|.|..|||  ||...:..
 Frog  1843 KLVQNLNFDAHLEASALRDN-LGVQQTEPSSE--SLLLEAAKQVKVSDLEEDQLELPEEENVVNM 1904

  Fly  1943 TQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYDFRFSTNKIREV 2007
            ...::.:..||||:|::|:|||:|..:.|.:||......|.|.|...|:|..:||::..::|||:
 Frog  1905 NDKEEQIQKEKLVLSEECDLITVMDAISGHLEVTTQHIYFYDGSTEKEEGVGFDFKWPLSQIREI 1969

  Fly  2008 HLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGLPLPNILYGSGRSPAELLRASGLTQ 2072
            |||:||||||||||||:|||:|||||..:.||||:::|:.|.|||| ||: |||.|||:||||||
 Frog  1970 HLRRYNLRRSALEIFLIDQTNYFLNFKKEVRNKVYSRILSLRLPNI-YGT-RSPQELLKASGLTQ 2032

  Fly  2073 RWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINP 2137
            :|:|||||||:||:.|||||||:||||:|||||||:|.||||:.|||.:|..|||||||||.:|.
 Frog  2033 KWVNREISNFDYLIQLNTIAGRTYNDLAQYPVFPWVLQDYTSEELDLNNPAVFRDLSKPIGVVNE 2097

  Fly  2138 KNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFH 2202
            ||.|.|:.||:|||||.|.|.||||||||||:|||:|||:||||:|:|||.|||||||.||||||
 Frog  2098 KNAAIVKDKYESFEDPLGTIDKFHYGTHYSNAAGVMHYLIRVEPYTTLHIQLQSGRFDCADRQFH 2162

  Fly  2203 SIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTPEEFIA 2267
            |||.||:.||||||||||||||||||||||:|.|.|||||||||||:|:|||||.||.:||:||.
 Frog  2163 SIPATWQALMDNPNDVKELIPEFFYFPEFLENKNGFDLGHLQITKEQVNDVILPKWAKSPEDFIL 2227

  Fly  2268 IHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGM 2332
            .||:|||||:||.|||.||||||||||:||.|.|||||||||:||||||||.|.|..||:|:|||
 Frog  2228 KHRKALESEFVSAHLHEWIDLIFGYKQRGPAAIEALNVFYYCTYEGAVDLDAIANEKERKALEGM 2292

  Fly  2333 INNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSP 2397
            ||||||.|.|||:||||.||:.:|..||..:.:....:|.|.|..:..::.|..:...|:|....
 Frog  2293 INNFGQTPCQLLKEPHPTRLSAEEVYLKQSKLDNVTLNLFQNLPDLKSFFIEGISDDVPVVKAIV 2357

  Fly  2398 PRSPPRSFLQL-SPDVLVSISKSTILGCNSWLSFDK--DQGFLLEIDATTANLKNRKRIFGPFHS 2459
            |::..||||.. ||::||::|::.|:|.:.||.:|:  ...|....|.|..|.|.::.:.|||..
 Frog  2358 PKNQLRSFLSPGSPELLVTVSQTLIIGTHGWLPYDRTISNYFTFSKDQTVTNPKTQRLVSGPFAP 2422

  Fly  2460 SQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSYLVTGS 2524
            ..:..|:||.||.|||:|::||.||||:||.:|.|||..:...||:||:||::.|.||.:|::||
 Frog  2423 GLEITSKLFVVSHDGKVLFSGGHWDNSIRVTSLTKGKVTSQHIRHMDIVTCLSTDFCGIHLISGS 2487

  Fly  2525 RDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVA 2589
            ||.||::|  |..||||                           ..|.|||.:||||.|.|:||.
 Frog  2488 RDTTCMIW--QIGQQGG---------------------------DLSSKPLQILYGHTDEITSVC 2523

  Fly  2590 IYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTLSYHGHIAF-SALDDTS- 2652
            |.||||..|||:.||.|.::|::.||:||||||...:...:.|..:.:|..|||.. |:::..|
 Frog  2524 ISTELDTAVSGAKDGAVIIHTIRRGQYVRTLKPPSESSLLMSIPNLAMSLDGHIVIHSSIEGKSI 2588

  Fly  2653 ---HSVHVYSINGCSLGSKYVSGRVTGLASASDYLVVADDAGDITMSRLHGLK-PVFDIPLHVPI 2713
               :::|:|||||..|.|:.:..:||.:...|:.:|:....|.:::..|:.|. .:..:.:.|||
 Frog  2589 KNKNALHLYSINGKYLVSELLKEQVTDMCIISENIVLGSRQGFLSIRDLYSLNLSLTPLVMRVPI 2653

  Fly  2714 QTVVVTPGNTHILAPLRDGRLAVIAVQLPS 2743
            ..|.||..|:|||..|.||:|.::.:..|:
 Frog  2654 HCVSVTKENSHILVGLEDGKLIIVGIGKPA 2683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	Laminin_G_3	644..752	CDD:463865	45/123 (37%)
		DUF4704	906..>1162	CDD:464870	95/263 (36%)
		DUF4800	1646..1899	CDD:464996	82/252 (33%)
		PH_BEACH	1952..2046	CDD:275391	50/93 (54%)
		Beach	2072..2351	CDD:460459	214/278 (77%)
		NBCH_WD40	2395..2742	CDD:466575	134/355 (38%)
		WD40 repeat	2465..2503	CDD:293791	21/37 (57%)
		WD40 repeat	2509..2580	CDD:293791	23/70 (33%)
		WD40 repeat	2585..2621	CDD:293791	20/35 (57%)
nbeal1	XP_002937765.2	DUF4704	888..>1159	CDD:464870	102/286 (36%)
		DUF4800	1610..1863	CDD:464996	84/258 (33%)
		PH_BEACH	1914..2011	CDD:275391	51/96 (53%)
		Beach	2031..2311	CDD:214982	215/279 (77%)
		NBCH_WD40	2374..2682	CDD:466575	127/336 (38%)
		WD40 repeat	2472..2514	CDD:293791	23/70 (33%)
		WD40 repeat	2519..2556	CDD:293791	21/36 (58%)
		WD40 repeat	2564..2592	CDD:293791	7/27 (26%)