DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and nbeal2

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_031760024.1 Gene:nbeal2 / 100486550 XenbaseID:XB-GENE-6038810 Length:2788 Species:Xenopus tropicalis


Alignment Length:2941 Identity:952/2941 - (32%)
Similarity:1504/2941 - (51%) Gaps:411/2941 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NKKDIYNL--WVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQP----DSGPHL 61
            ||||:..|  |::           .||..|              |...:...::|    ||...:
 Frog    23 NKKDLNYLQQWLE-----------AFVTNF--------------EKIILVQTLEPRRPEDSSSEI 62

  Fly    62 GRLPDELLPAIGKFIIVARDVCE--TEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKP 124
            ..||.::|..:.:.:   |...|  ..|:..:.::.:..:|:...:|:.|:.:|    ::.|..|
 Frog    63 PVLPRDVLRVLSQQL---RRCTEDLASGQEADTSLCQAFLLLKFFIIISRNLEN----VEKERTP 120

  Fly   125 ----NLIAILSRVFKQQMELPQ-SVPAISHLFSSFSA-----FLEVMYDPYLTWRSFVRGQ---S 176
                .:|.:|: |...|::.|. ...|.|.|.:...|     ..|.::|||.|||....|:   :
 Frog   121 IFVCEVIHLLT-VSVTQLKNPSLEETAESRLLNEKVAIYALHLCECLFDPYQTWRRQRGGEIVSA 184

  Fly   177 ADYSRLSYKPHSVHVEIVPFIYDCFQEEKLIRYAEIGES--------LLNILGAVICGSQLQLKV 233
            .:.|:..:.|.::..|...|.....::         |||        |:::.||:|.||:     
 Frog   185 KEKSKYKFSPAALPAEFCTFFQIALRD---------GESLPEPVILRLVHLYGAIITGSK----- 235

  Fly   234 QKSLNSTSTLTNRNTNALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQWESANNL 298
                                                 :|.:..|...:|.:.|.:|..|..::|.
 Frog   236 -------------------------------------QNALLLITSESVEVLMLVLWNWCISHNA 263

  Fly   299 R-----RVALQCYALMVIVLQKSSPEERQIDLVTLVQLYCDALQ--------ELLATKHFDSG-- 348
            |     ::||:|...::.:|..|||.||::::..:::.|...|.        |..:..|.:.|  
 Frog   264 RNPHILQLALECLISIIHILHGSSPGERRVEIRNILERYFKVLNTDRPLSSLERKSEPHLEEGLL 328

  Fly   349 -------DANFDITSDADQDVAIDMAALSST--------VAAVKFFVTGDAGVSEAVSDSNLLEL 398
                   .|..::.:.||:.| :....||:.        :...|.:::......|:..|.. .:|
 Frog   329 ALRIGMLRAIPEMLNCADRPV-LQAIFLSNNCFEHIIRLIQNSKLYLSRGRAPEESGRDLT-TQL 391

  Fly   399 LTNLPKLIKPWHISHSSSLCSTMEALAILA---RHSPQSASQLRQGERIERLFTSLQEYGSPTVE 460
            ||.|.  |:....|.|.|:  |:.|:.:|.   |:||.:....::......|:..|:.....|..
 Frog   392 LTELD--IRKVLDSDSDSI--TVNAIGVLTSIMRNSPAAKEVFKERIGYSHLYEVLKSRSQSTKP 452

  Fly   461 LLDTCFMLGYDE-----SEHFLLLPEVMLRLLNWVPTLQERE-QLHVTSLVLKGCTDNYRTKTVA 519
            ||.....:..:.     |.|.:...:.:|.|:.|:|.|..|: |:.|:..:...|..:.:.:.:.
 Frog   453 LLQELLNMAVETDHNSCSMHCIQNEQPLLILVQWIPELAPRDIQILVSEWLKSTCDSSLQNRMIC 517

  Fly   520 CGSHIIKAVCGCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLR-QGTKFPQFKQLQ 583
            ..:.::..:...|.....|...||:|||.|::.|.:|||.|.||:.:..||| :|....::    
 Frog   518 VQAGMVGQILLALQHETELDGKCVENLIHLLQVLGRLSIRPTELRDLLRLLRTEGNCCHRY---- 578

  Fly   584 QTLVVIALQSLR---GSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRFNQLKEQ-- 643
            .|.|:.||.::.   |.....::|.:.....||:||.::.|.   ..||.||..|..|::...  
 Frog   579 ATQVIRALSAMARKDGPERALQYFDLTPSMSGIMVPTMQKWP---GTGFAFHAWVCLNEVGTDEL 640

  Fly   644 --SNSRRMLLTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPP 706
              ...|:.|.:...|||:|||.|...:|.:|||..|::||:|.:.......|..||.|.:.....
 Frog   641 LAGRKRKQLYSFFAASGTGFEAFFTTDGMLVVAVCTKKEYMTVALPEFQFNDSMWHCLDIVHVAG 705

  Fly   707 KRPFSYSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGS 771
            :|||..:.:|||.|...:..|.|:..::||.||.|.||:            .||  |:::....|
 Frog   706 RRPFGQNMVNIYTDGQLRKVAQLRFPSLNESFTSCCIGS------------AGN--RTTTTIVTS 756

  Fly   772 SGYKGMLPSLLERTLSANVSNYFTLPMR------TQTAFDPNVKNFPIGMQDTVFGEQTCLNGHL 830
            ..:...|.......||.:.|...:.|:.      .|.:.:..|.....|.|||.:|..|.|.|||
 Frog   757 PNHAPDLTFASHSALSRSQSFPASAPVHGWGQGSAQNSREAQVSVIVAGTQDTEWGRPTSLEGHL 821

  Fly   831 GGVLLADPT---TSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKY 892
            |.|.:...|   ..:|.::.||.|:.:.|..:::..:|..:.:..|.|.|..:..|.||.|...:
 Frog   822 GTVAIFHDTLQANHVKALYLAGPNYVTPFKPESEFSDLGPKLLLFYTPQASKNNICLDLSPSRLF 886

  Fly   893 PGRINAQHCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFT 957
            .||:.........|::.:|.:||:.|.||:|::           :.|.:.|:|.   |....:..
 Frog   887 DGRLTGHRVVTWDIKDVVNCVGGMGAFLPLLNQ-----------VASQTSEALE---TQETHDLV 937

  Fly   958 DWEMLSSNS----------YTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQ 1012
            ..|:.||.:          .:|.::.::.:|:||.:::.....|..|||.||.....||:|.::|
 Frog   938 GPELTSSRNAQGMQLPLGKSSESRLERNGVAAFLLMIKNFIQHHPVNQESLLQCHGSAIIGALMQ 1002

  Fly  1013 RCPPSLFDVNALMATHLLMESLQGHKAEAGGQ--LLDALYAHIVFDFAIWSRLQFQITLGHAQYL 1075
            :..|...|:|.|||:.:||:     :..:.||  ||..||.|::|||.|||...|.:.|||.|||
 Frog  1003 KVSPLTMDMNVLMASQMLMD-----QVSSDGQSVLLHHLYQHLLFDFRIWSNSDFAVRLGHIQYL 1062

  Fly  1076 SAMIKNDRKFFRKRYGVQFVLDVVRQYYST----PDSISDDDAKTIRATLFGIIKFYLQKDVNIK 1136
            |.::|:.::..||:||||::||.||::|.|    |:::  |:.||::.:||.:.|.:|.|::..:
 Frog  1063 SNIMKDHKQRVRKKYGVQYILDSVRKHYGTQKEDPNTV--DNVKTVQMSLFALTKDFLSKNLCPE 1125

  Fly  1137 EVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQ 1201
            :::|:::::|:|..:..:...||::...:|.....|.:...|.||.:.|:.|...:.||||::::
 Frog  1126 DLHSVLSYIAAVNDEEQVSGMLEVLHSLLRANVSNDLLYTFLLEPWNVNIFYALLIQKSYSDQVR 1190

  Fly  1202 EAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLG--L 1264
            |...:.:..||...:||::.|..|:|     .:..:.|..||::.:.:|..::..|.:::||  :
 Frog  1191 EKVFKILYKLLKYEKVHERIKHRLKL-----REIGYQGLISFLSEVPVSMLLIRCLSEQVLGSDV 1250

  Fly  1265 QPDYAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITSS 1329
            .|:|..|:.:||.....:|||||::.::|....:.:|.....:|||||||:.:.:|.|::...|.
 Frog  1251 SPNYKDLLSVVYLSHRAELPVKLDVCRKLFHLIYSQQDIVRHLAKQTGWQDILTKLYIKESYESR 1315

  Fly  1330 P--------------------PDEEKRRSF----------GINLD------VLLEDNSNFLAQAD 1358
            |                    ..|||..::          ..|.|      |..|.:.:..::. 
 Frog  1316 PRSLSSPMYYGALSLLKSMGSSKEEKSETYKECLNGHHGAAENQDVDTVFPVSFEASDHDFSEG- 1379

  Fly  1359 LITFSEQEIGLAQLQQQ------QQEELSD--SGLILNEIQASVTEAATVIESEIKE-------- 1407
               ||:..:..|..|:.      :..:.||  |....|.|....:|.|...:..:.|        
 Frog  1380 ---FSDHSLSPAHKQKSFRAYGFKSFDSSDQVSHCSSNNIDMPCSEEANCADGHLFENAYQPLSP 1441

  Fly  1408 -----------LAESVSGAVVENANSLFSVIRQTTHDLQDTFESL------TQGSSTDTADGSQT 1455
                       ||.:.|.|.:|:.| |..|.:..|....:||:..      ...|.::..|.|  
 Frog  1442 FSMSPFEVRLDLASASSAATIESGN-LTPVSQSGTPSPLETFKPFPGMRVRKSSSLSNVLDES-- 1503

  Fly  1456 PSIQREESLSSDTSSQSPHGPPKKSDSLESTSAFDFVADGDVDTEEQLVYLVSNTLFNIFWRGIP 1520
               ..:|:|.|||:|.:.:  |:::                  .||:|..|::|.:|::.|||:.
 Frog  1504 ---SYQETLPSDTASNTSN--PQQT------------------PEEELCNLLTNIIFSVTWRGVE 1545

  Fly  1521 NDHPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVNQENASH 1585
            ......|:|||||...:..|....||:.....::..:|||.::::..|:.|.....|.:.  ..|
 Frog  1546 GQDDLAWKERGQVFSVLTKLGSACELVRPPDEIKRSLLEMMLESAFTDIKESTPAALPSL--IQH 1608

  Fly  1586 ILRMVYELVVLGSNEDESKKC--STKLLDGVLALLDALMIFQQ--GSSDDWSDM----IRLCLGL 1642
            :|:::..|.....:|.:|.:.  |.|:.:||..|||.|.::..  ..:.|..:|    :|:.||.
 Frog  1609 VLKLLRLLQDFLFSEGQSNELLWSEKIFEGVSNLLDKLGVWYHLANGTSDLKEMAQIGLRIILGF 1673

  Fly  1643 LLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSINRALDNAIEVGNPEEYSFLMPVM 1707
            :.....|.:    :.|..|||.:||:..|....|..:||..:...|..:: ....|..|:|:|::
 Frog  1674 IKLEDRHMH----SSAYVKLHNLLQTACTPQKEEACFLLGKLEAPLMGSL-YAKTENASWLVPII 1733

  Fly  1708 KALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQRDIELHL 1772
            :.|:::|..:..|...||.||.|:..|.|::||..:.|:.:||.||::.|:|..:::::|.....
 Frog  1734 RTLMDQCFESLELQYHLPSLPPTNGSPNFYDDFLTFCTTLEWRAFIDKHVQPTMEQFEKDTFAKS 1798

  Fly  1773 WEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWKVRQVEEMQRLQAAALQHKTIDSH 1837
            ...::.||..||:|..::|.:|.:.:.|:|..||:.:......|...|..|..:..   |.|:||
 Frog  1799 HHQMSLFWNSCYDALMSSSLRRESEKGESRTKFQEYVLEQVMKRTKNENARYSSVL---KQINSH 1860

  Fly  1838 ---IRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKLEPQLYPNKHENAANLRDN 1899
               |.::|::..|.|..|||.|......|..||:|..|..:||||||.|....:.|:.|:..|||
 Frog  1861 HNTILRQWRSLLRLLSCPRGAWADRNPPEVKWKISSAETYSRMRLKLVPNYNFDPHKEASAQRDN 1925

  Fly  1900 ATSAYDTKEISEFDSTI-KNAVVRDFLADDESSQL-EEELRQLIDTQAQQDVALEKLVMSQDCEL 1962
            ..:.|.......|...: |.|.|.:.    |..|| :|:|:.:...:.::....||||:|:||||
 Frog  1926 LGTDYTQSLTDSFPLAVAKEAKVNEM----EDDQLGDEDLKNMNQVETKEPNQKEKLVISEDCEL 1986

  Fly  1963 ITLMTKVKGRIEVNQSVFTFVDLS---PPTEDGSKYDFRFSTNKIREVHLRKYNLRRSALEIFLV 2024
            ||::..:.||:||......|.|:|   ..||:|..||||...:::||||||:|||||||||.|.:
 Frog  1987 ITVVAVIPGRLEVTTQHIYFYDMSNEKEETEEGIGYDFRRPLSQLREVHLRRYNLRRSALEFFFI 2051

  Fly  2025 DQTSYFLNFTTKTRNKVFTKIVGL-PLPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYL 2088
            ||.:||:||..|.||||:::|:|| ||.....|| |||.|:|:|.||||:|:.||||||||||.|
 Frog  2052 DQANYFVNFKKKVRNKVYSRILGLHPLSQSTLGS-RSPQEMLQALGLTQKWVWREISNFEYLMQL 2115

  Fly  2089 NTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDP 2153
            ||||||:|:||||||||||||.||.|:.|||.:|:.|||||||||.:|.|:..||:.||:|||||
 Frog  2116 NTIAGRTYSDLSQYPVFPWILRDYVSETLDLNNPEVFRDLSKPIGVVNEKHAREVKEKYESFEDP 2180

  Fly  2154 SGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDV 2218
            :|.:.||||||||||:|||:||::|:||||:|||.|||||||.:||||||||..|:..|:||.||
 Frog  2181 TGTVDKFHYGTHYSNAAGVMHYMIRMEPFTTLHIQLQSGRFDCSDRQFHSIPAAWQARMENPVDV 2245

  Fly  2219 KELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLH 2283
            ||||||||||||||:|.|.||||.|||:..||:||:||.|:|:.|:.|..||:|||||.||.|||
 Frog  2246 KELIPEFFYFPEFLENANGFDLGCLQISNGKVNDVVLPKWSTSREDLIYQHRKALESEDVSLHLH 2310

  Fly  2284 HWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPH 2348
            .||||||||||:|..|.|||||||||:|||.||||.|.:..||:|:||:|:||||.|.||.:|||
 Frog  2311 EWIDLIFGYKQRGAAAVEALNVFYYCTYEGVVDLDAIADETERKALEGIISNFGQTPCQLFKEPH 2375

  Fly  2349 PRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPPRSFL-QLSPDV 2412
            |.|:|.:..|.:|.|.:...|::.:.|.::..::.|......|:|....|::...||: |.|||:
 Frog  2376 PPRMTAEHAARRLSRMDTYSPNVFENLAELKSFFVEGMMEGVPLVLTVVPKTQAHSFMTQGSPDI 2440

  Fly  2413 LVSISKSTILGCNSWLSFDKD--QGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGK 2475
            ||::|.:.:||.:.||.:||:  ..|....|.|.:|:|.::.:.|||....:..|:...||.|.|
 Frog  2441 LVTVSSNGLLGTHGWLPYDKNISNYFSFTKDPTVSNVKTQRFLSGPFALGAELSSRTLVVSHDAK 2505

  Fly  2476 LLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQG 2540
            ||::||.|||||||.:|:|||.:..:|||:|:::|:|||.||.||::||||.||::|  |..|||
 Frog  2506 LLFSGGHWDNSLRVTSLSKGKVIGHITRHIDVVSCLALDLCGIYLISGSRDTTCMIW--QVLQQG 2568

  Fly  2541 GGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGT 2605
            |.|.                        ..||||:.||:||||.::.|||.||||:.||||.|||
 Frog  2569 GISC------------------------GLSPKPVQVLFGHDDEVTCVAISTELDMAVSGSKDGT 2609

  Fly  2606 VNVYTLQEGQFVRTLKPIGCTESC-VQISFVTLSYHGHIAF-------SALDDTSHSVHVYSING 2662
            |.|:|::.|||:|.:|| .|..|. :.||.:.:...|.|.|       ::|.| ..::|.||:||
 Frog  2610 VIVHTIRRGQFMRCIKP-PCESSLPLTISQLAVGLEGQIVFQSTIEGRTSLKD-KFTLHYYSVNG 2672

  Fly  2663 CSLGSKYVSGRVTGLASASDYLVVADDAGDITMSRLHGLKP-VFDIPLHVPIQTVVVTPGNTHIL 2726
            ..|.::.:..:||.|..|.||||:......:.:..|..||| |..:|:.||:..|.||..|:|||
 Frog  2673 KHLATEALEEQVTALCIAQDYLVLGTMQCSLQIRELRSLKPAVPSMPMKVPVYCVSVTKENSHIL 2737

  Fly  2727 APLRDGRLAVIAVQLP 2742
            ..|.||:|.|:....|
 Frog  2738 VGLEDGKLIVVGAGQP 2753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 37/112 (33%)
DUF4704 906..1162 CDD:292415 85/271 (31%)
DUF4800 1650..1899 CDD:292675 76/251 (30%)
PH_BEACH 1952..2046 CDD:275391 52/96 (54%)
Beach 2072..2351 CDD:280327 195/278 (70%)
WD40 <2428..2734 CDD:225201 130/316 (41%)
WD40 repeat 2465..2503 CDD:293791 20/37 (54%)
WD40 2468..2687 CDD:295369 100/226 (44%)
WD40 repeat 2509..2580 CDD:293791 27/70 (39%)
WD40 repeat 2585..2621 CDD:293791 21/35 (60%)
nbeal2XP_031760024.1 DUF4704 895..1154 CDD:406270 85/279 (30%)
DUF4800 1673..1926 CDD:406460 78/260 (30%)
PH_BEACH 1976..2076 CDD:275391 54/99 (55%)
Beach 2098..2378 CDD:214982 196/279 (70%)
WD40 repeat 2497..2533 CDD:293791 19/35 (54%)
WD40 2503..2776 CDD:421866 119/279 (43%)
WD40 repeat 2539..2584 CDD:293791 27/70 (39%)
WD40 repeat 2636..2679 CDD:293791 13/43 (30%)
WD40 repeat 2684..2718 CDD:293791 13/33 (39%)
WD40 repeat 2724..2747 CDD:293791 11/22 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 467 1.000 Domainoid score I459
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1507 1.000 Inparanoid score I102
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 1 1.000 - - FOG0003051
OrthoInspector 1 1.000 - - otm49264
Panther 1 1.100 - - LDO PTHR13743
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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