DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43367 and wdr81

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	XP_002937192.2	Gene:	wdr81 / 100485582	XenbaseID:	XB-GENE-6258221	Length:	1871	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	201/974 - (20%)
Similarity:	324/974 - (33%)	Gaps:	381/974 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1707 MKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQRDIELH 1771
            |:.|||..:...|:||....:....:..:..       .|:||...|:.         :|.:.
Frog     1 MEWLLEAVKKELNIDSRQLIMAEEGTHVIAL-------VSQKWLASIKE---------RRTVS-- 47

  Fly  1772 LWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIY-MP--WKVRQVEEMQR--------LQ 1825
                     ::|       .|....:..|.:...|:.:: :|  |...::..:::        |.
Frog    48 ---------SQC-------PKPEGFSSVEIQTFLQRSVHKLPAGWTRIEIHGVRKERLAYPVALN 96

  Fly  1826 AAALQHKTIDS-------------HIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARM 1877
            ...|:.|.|||             :....|..|:|....|.         |...|:...:.:..:
Frog    97 DGFLEGKNIDSESLIRFMQCIAVQNYNNMWNAARRTYVQPY---------ESVHKVPSIQALDAL 152

  Fly  1878 RLKLE-----PQLYPNKHENAANLRDNATSAYDTKEISEFDSTIKNAVVRDFLADDESSQLEEEL 1937
            :|.|:     |.::.||         ...|...:|:.|.|           .|....||.:
Frog   153 KLSLQRVYGCPFVFINK---------AVPSLSPSKDSSSF-----------VLGASSSSNI---- 193

  Fly  1938 RQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYD-FRFST 2001
                       |..|.|:.|.....|.|                      |....|.|| ..||.
Frog   194 -----------VQAEALLESVSILYIIL----------------------PYIQYSLYDVVTFSP 225

  Fly  2002 NKIREVHLR----KYNLRRS--------------ALEIFLVDQ------TSYFLNF-----TTKT 2037
            .|:...|.:    .||:.::              .|...|||:      ...|:::     :||.
Frog   226 AKLANSHAKVLFILYNVLQALKACHQGGLSSGALTLRSVLVDEKLCSQLRPNFIDYERECKSTKV 290

  Fly  2038 RNKVFTKIVGLPLPNILYGSGRSPAELLRASGLTQR-----------WINREISNFEYLMYLNTI 2091
            :..:.|                   |.||..||...           ||:..|||::||||||.:
Frog   291 KENINT-------------------EQLRTVGLCTSCNNELKQILIDWIHGRISNYDYLMYLNKL 336

  Fly  2092 AGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYD----SFED 2152
            |||...|.:.:||.||:: |:|      |....||||.|....:| |.:.::...|:    :|..
Frog   337 AGRREGDPNYHPVLPWVV-DFT------TKNGKFRDLRKSKFRLN-KGDKQLDFTYEMTKQAFVA 393

  Fly  2153 PSGAIPKFHYGTHYSN-SAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDN-- 2214
            ...:....|...|.|: .:.:.:|:.:..                         :|.|:::.|
Frog   394 GGSSSDHLHVPHHISDVLSDITYYVYKAR-------------------------RTPKIVLCNHV 433

  Fly  2215 -----PNDV------------KELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTP 2262
                 ||:.            .|.||||:..|...|:::. |:..|:|          |:|.::.
Frog   434 RSQWEPNEYPASMERMQGWTPDECIPEFYTDPTIFKSIHT-DMPDLEI----------PSWCSSY 487

  Fly  2263 EEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVERE 2327
            |:||.:||..|||..|||.|||||||.||||..|..|....||..:.       :|..||
Frog   488 EDFIHVHRALLESRDVSQDLHHWIDLTFGYKLTGKNALMEKNVCLHL-------VDNHTN----- 540

  Fly  2328 AVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVV---QYYCELSTPK 2389
                 :..||.|  ||..:|||:||.              .|..:.|....:   |...::|..|
Frog   541 -----LTCFGVV--QLFDQPHPKRLL--------------GPSCSSFEPPAILSTQNISQMSAWK 584

  Fly  2390 D---------PI--------VYLSPPRSPPRSFLQLSPDVLVSISKSTILGCNSWLSFDKDQGFL 2437
            |         |:        |:.:.........|:...:.|.|:|   |:|..:      ||..:
Frog   585 DEHTGNGVNGPVVEATVCEAVWNTDKVCAGDEELEQGTEALDSLS---IVGKGN------DQVCI 640

  Fly  2438 LEIDATTANL---KNR------KRI-------------------FGP-----------------F 2457
            ..:..|:||:   :||      .||                   |.|                 .
Frog   641 PSVQVTSANIFQGENRPPGSKPNRISRATTNAEESQRKLLLPDSFNPVQALEELEKLDNFLLRGL 705

  Fly  2458 HSSQQP---HSQLFAVSTDG--------------KLLYAGGIWDNSLRVYNLNKGKAVASVTRH 2504
            ||:..|   .|::|.:|..|              ::::||.|.....:...|.:...|.:::||
Frog   706 HSTLLPVEKSSKIFPLSLLGLFQRDMQALGVMIAEIVFAGKIHTTPPKTSLLERYILVRNLSRH 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605
		DUF4704	906..1162	CDD:292415
		DUF4800	1650..1899	CDD:292675	35/220 (16%)
		PH_BEACH	1952..2046	CDD:275391	23/123 (19%)
		Beach	2072..2351	CDD:280327	89/313 (28%)
		WD40	<2428..2734	CDD:225201	25/139 (18%)
		WD40 repeat	2465..2503	CDD:293791	9/51 (18%)
		WD40	2468..2687	CDD:295369	10/51 (20%)
		WD40 repeat	2509..2580	CDD:293791
		WD40 repeat	2585..2621	CDD:293791
wdr81	XP_002937192.2	PKc_like	188..>267	CDD:419665	20/115 (17%)
		Beach	318..557	CDD:100117	89/301 (30%)
		WD40	1569..1869	CDD:421866
		WD40 repeat	1580..1623	CDD:293791
		WD40 repeat	1628..1662	CDD:293791
		WD40 repeat	1671..1705	CDD:293791
		WD40 repeat	1712..1753	CDD:293791
		WD40 repeat	1761..1794	CDD:293791
		WD40 repeat	1802..1822	CDD:293791
		WD40 repeat	1846..1869	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010