DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43367 and nbeal2

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_009290461.1 Gene:nbeal2 / 100330830 ZFINID:ZDB-GENE-100922-283 Length:2831 Species:Danio rerio


Alignment Length:2985 Identity:950/2985 - (31%)
Similarity:1481/2985 - (49%) Gaps:434/2985 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDNKKDIYNLWVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQP----DSGPHL 61
            |.:|:.:|.||:.|.||.|..:.:|::..|||.:...:.:          |.::|    :....:
Zfish     1 MASKERLYELWMLYYTKKDVVYLQQWLEAFVASFEKVIDV----------HSIEPRRLEEWSADV 55

  Fly    62 GRLPDELLPAIGKFIIVARDVCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKPNL 126
            ..||.|:|..:...:  ........|:.:........:|:...:|:||:.:||.|    |..|..
Zfish    56 PLLPKEVLVFLSTQL--WHSALHMSGQDQSITAPHPLLLIKFFIIICRNMENIDS----EKTPGF 114

  Fly   127 ----IAILSRVFKQQMELPQSVPAISHLFSSFSAFLEVMYDPYLTWRSFVRGQSA---DYSRLSY 184
                |.:|:....|..:.|.....:..:........|.::|||.|||....|:..   :.|:..:
Zfish   115 VFETIKLLNFCLAQLKKQPDDQSTLQAVVQHGLLLCENLFDPYQTWRRRQAGEEVSMLERSKYKF 179

  Fly   185 KPHSVHVEIVPFIYDCFQEEKLIRYAEIGESLLNILGAVICGSQLQLKVQKSLNSTSTLTNRNTN 249
            .|..:..|:....::..|:.:||. ..:...|:::.||||.|.:                     
Zfish   180 SPLVLPEELPMLFHEYLQDSELIP-EPLVVRLVHLQGAVISGCK--------------------- 222

  Fly   250 ALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQW----------ESANNLRRVALQ 304
                                 |||:.:|.|..|...||:||.|          .....|.|:||:
Zfish   223 ---------------------RNGLLSITPQAVKDLMSVLRSWCLCPASSPQQPRDPQLLRMALR 266

  Fly   305 CYALMVIVLQKSSPEERQIDLVTLVQLYCDALQELLATKHFDSGDANFDITSDADQDVAIDMAAL 369
            |..:|:.:|..||..|||:::.:.:..|...|              |::...|:.|.   ||.|.
Zfish   267 CLTVMIHLLHSSSVNERQVEIRSALDDYFQLL--------------NWNRPPDSQQG---DMHAW 314

  Fly   370 SSTV---------AAVKFFVTGDAGVSEAVSDSN-----LLELLTNLPKLIKP------------ 408
            ...:         |..:.....|..|.:|:..:|     :|.|:.| .||.:.            
Zfish   315 EDNLITLLEHMLNAIPEILQCSDRPVLQAIFLNNNCFEHILRLIQN-SKLYQSNRFKLECEGQCD 378

  Fly   409 --------------WHISHSSSLCSTMEALAILA---RHSPQSASQLRQGERIERLFTSLQEYGS 456
                          |   ...|.|.|:.|:.:|.   .:||.:....::.....:||..|:..|.
Zfish   379 LTTRLLTESEVEQVW---EKGSDCITVHAIRVLTAIMSNSPSAKEVFKERIGYSQLFDVLKSQGQ 440

  Fly   457 PTVELLDTCFMLGYDESEHFLLL------PEVMLRLLNWVPTLQERE-QLHVTSLVLKGCTDNYR 514
            ||..||.....:.. |.||...:      .:.:|.||.|:|.|..|. ||.|:..:...|.....
Zfish   441 PTKRLLQELMNMAV-EGEHSQAMQLGISNEQPLLLLLQWLPDLGSRSLQLLVSQWLAAVCRGTLS 504

  Fly   515 TKTVACGSHIIKAVCGCLLTA-----ESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLRQGT 574
            .:||:..:.::    |.||..     |.|...|..:|:.|:::|..||:.|.|||.:..|||...
Zfish   505 CRTVSVEAGLV----GSLLEVLSEPPERLDRQCADSLLGLLQDLGSLSLRPCELKSLLKLLRTEP 565

  Fly   575 KFPQFKQLQQTLVVIALQSLRGSNSCA--EFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRF 637
            ..|......:.:.|::..:.||...|:  ::|.:..|..||:||.|:.|  .|| .|.||..:..
Zfish   566 GAPPHPYCGRVVRVLSAMAARGEGGCSALQYFDLTPPMAGIMVPAIQRW--PGS-AFAFHAWLCL 627

  Fly   638 N-------------QLKEQSNS--------RRMLLTLQTASGSGFEVFVQPNGNVVVAALTRREY 681
            |             .|....|:        |:.|.:..||||:|||.|......:|||..|::||
Zfish   628 NTDFPPPQHHYSESHLTNMDNTVRMAKGPRRKQLYSFFTASGTGFEAFFTTEEVLVVAVCTKKEY 692

  Fly   682 LTSSTATKTLMDGQWHYLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGA- 745
            :..|.......|..||.:.:...|.:|||..:.:.:|||.||..:|.|:..::|||||.|.||: 
Zfish   693 MAVSLPEHPFNDCAWHSVAIVHVPGRRPFGQNVVTVYVDGVQCKTAPLRFPSLNEPFTSCCIGSA 757

  Fly   746 ---------VVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNYFTLPMRTQ 801
                     ..:|..|       |.|.|.| |...:.:.|  |..|.|:.|...|.......|..
Zfish   758 GHRTTTTTMTTSPTLP-------NPPHSPS-EMAFAAHTG--PPTLLRSQSFPASFAAAAGGRPG 812

  Fly   802 TAFDPNVKNFPIGMQDTVFGEQTCLNGHLGGVLL---ADPTTSLKTIFDAGANFSSIFSQDNDLL 863
            ...:..|.....|:|||.:|..:.|.|.|....:   |......:.:|.||.|..|:|..|.:..
Zfish   813 GNRESPVHTIQAGLQDTAWGSPSSLGGLLATAFICHEALQPAQARALFTAGPNNVSLFKADGEPS 877

  Fly   864 ELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIVKIQETINSIGGISAILPMLHRLIT 928
            |:||:.|..|.|.|.....|.||.|...|.||:.........:::.::|:||:.|:||:|.::..
Zfish   878 EVNSKLVLYYTPKAFKSQICLDLSPNHLYDGRLTGHRVVNWDVKDVLSSVGGMGALLPLLEQVCL 942

  Fly   929 LDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHET 993
            |||..  ::|..:.:.|  .|..::.......:|.....:|.::.::.:|:||.:::.:...|..
Zfish   943 LDQRE--TVGQETSDLL--GPELTSSRGPAGMLLPLGKSSEGRLEKNSVAAFLLMIKNMLRNHPA 1003

  Fly   994 NQEQLLSSECLAIVGTMLQRCPPSLFDVNALMATHLLMESLQGHKAEAGGQLLDALYAHIVFDFA 1058
            |||.||.....||:|.||.:.|.|:.|::.|||...|::.:..   |....||..||.:::|||.
Zfish  1004 NQESLLQCHGPAIIGAMLGKVPSSMMDMSVLMACQFLLKQVSN---EGNNALLSQLYQYLLFDFR 1065

  Fly  1059 IWSRLQFQITLGHAQYLSAMIKNDRKFFRKRYGVQFVLDVVRQYYSTPDSIS--DDDAKTIRATL 1121
            ||||..|.:.|||.|||:.:|...:...|::||||::||.:|.:||.....|  .|:.:|::.:|
Zfish  1066 IWSRSHFAVCLGHVQYLTTVINEGKLKTRRKYGVQYILDSIRTHYSVEKDGSPLSDERQTVQISL 1130

  Fly  1122 FGIIKFYLQKDVNIKEVNSMITFLASVRQDVVLVEFLEMM-TFYVRGKNCKDQMVLLLHEPQSAN 1185
            |.::|..| |....:|::|::.:.|.|:.:..::..|::: |........::|:|.:|.: :...
Zfish  1131 FSLLKDLL-KSPTAEELHSVLAYAAIVQDEQQVISVLDVLHTVLKSSPPPREQVVTVLLD-RRVE 1193

  Fly  1186 LLYNFFVDKSYSNEIQEAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLS 1250
            .||...:..:|.:|.:|...|.:..:|.:.|||.:.||:::|.|     |.:.|.......:.::
Zfish  1194 QLYYLLLKTNYGDEARERLFRVMYKVLKSERVHDRNKQLIKLKD-----SGYLGLVCSFGDVPIT 1253

  Fly  1251 STILFHLVDEMLGLQ--PDYAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGW 1313
            .|.:..|.:::|...  |.:..|:.:||.....||..:|||.::|.......::....:|.|:||
Zfish  1254 MTTVRCLYEQVLATDPTPSFKDLLAVVYLSHRADLSARLEIVRKLFCLIHSNEEYVKQLAHQSGW 1318

  Fly  1314 QESIARLLIRKPITSSPPDEEKRRSFGI-NLDVLLEDNSNFLAQADLITFSEQE---IGLAQLQQ 1374
            |:.:.:|.:::...|....:....|... :||.:|  :.....:.|.:|...::   |.||...:
Zfish  1319 QDVLTKLYVKESYESRVRSQSNSLSSPTSSLDPVL--SRPVFRRDDSVTEDVRQNVYITLAARHE 1381

  Fly  1375 QQQEELSDSGLILNEIQASVTEAATVIESEIKELAESV--------------SGAVVENANSLFS 1425
            ::.||           :...|:.|:...|::.:...|.              ||....::::|.:
Zfish  1382 EEYEE-----------EEGETQDASEGFSDLSQSPPSTGQLKNDSLHFKPFDSGDQSSHSSTLSN 1435

  Fly  1426 VIRQTTHDLQDTFESLTQ-----GS----STDTADGSQTPSIQREESLSSDTSSQSP--HGP--- 1476
            .:......||:..|::.|     ||    ..:...|.|||       :.|...:.||  |..   
Zfish  1436 TVDFPPSRLQEEDEAVYQPLSPFGSPFELELNHQKGPQTP-------VGSQPETPSPLEHNKTFL 1493

  Fly  1477 ---PKKSDS----LESTSAFDFVADGDVDT----------EEQLVYLVSNTLFNIFWRGIPNDHP 1524
               |:||.|    |:.||   :..:...||          ||:|..|::|.:|::.|.|......
Zfish  1494 GMRPRKSSSLSNVLDDTS---YSTEPPTDTISNTSNPQAPEEELCNLLTNIVFSVLWIGTEGSED 1555

  Fly  1525 QCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVNQENASHILRM 1589
            ..|:|||||...:..|..:.:|:.....::..:|||.:::||.||.:....:|.:..:...:||:
Zfish  1556 VIWRERGQVFSVLTKLGSSCQLVRPPDDIKRSLLEMMLESSLSDLRDSQGVSLPHVPSLLRLLRL 1620

  Fly  1590 VYELVVLGSNEDESKKC-----STKLLDGVLALLDALMIFQ----QGSSDDWSDM----IRLCLG 1641
            :.:.:.....      |     |.|:.:||:.|||.|..:.    ...|.:..:|    :|:..|
Zfish  1621 LQDFLFAEGT------CNHTLWSEKIFEGVVNLLDRLKAWHTTPGSAGSAELKEMSLIGLRIITG 1679

  Fly  1642 LLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSI-------NRALDNAIEVGNPEE 1699
            .:   ....||.:..||..|||::||:.......|:.:||..:       |.|.|.:.| |.|  
Zfish  1680 YI---QQQQNPQVCEMACLKLHSLLQTVLCLSWEEVCFLLGRLGAPLCPANSASDTSAE-GLP-- 1738

  Fly  1700 YSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRY 1764
             |.|:|:::|||::......|...||:||:|:..|.|..|.|:|.::.:|:.|.:..|:|...:|
Zfish  1739 -SPLVPIVRALLDQHADHTTLQEKLPNLPATNGSPSFAQDLQIYCSTAEWQQFYQNHVEPTMQQY 1802

  Fly  1765 QRDIELHLWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWKVRQVEEMQRLQAAAL 1829
            :.|......:.::.||..|::...:..::|...:::::..||:.|..|:..|...|..|..:...
Zfish  1803 ELDTFGKSHDLMSNFWNSCFDDLMSTGQRRDKERSDSKAKFQEVIVDPYLKRVRTENSRYHSVQK 1867

  Fly  1830 QHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKLEPQLYPNKHENAA 1894
            ......:.:.:.|::.:|.|...||.|......|..||||..|..::|||||.|....:.|.:|:
Zfish  1868 MINGQQTVVWRHWRSLRRLLSSDRGAWPLRVQPEVKWKLSSAETYSKMRLKLVPNYSFDSHSDAS 1932

  Fly  1895 NLRDN--ATSAYDTKE-----------ISEFDSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQ 1946
            .||||  |.|...:.|           :|:.|.        |.|.|::...|||.      .:|:
Zfish  1933 ALRDNMGADSPRSSTEPLPLAVAREAKVSDMDD--------DKLEDEDIVFLEEA------EEAE 1983

  Fly  1947 QDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLS---PPTEDGSKYDFRFSTNKIREVH 2008
            ::...||||:|:||||||::..|.||:||......|.|.|   ..||:|..:||:...:::||||
Zfish  1984 EESQKEKLVLSEDCELITIVAVVPGRLEVTTHHLYFYDGSSEKEETEEGIGFDFKRPLSQLREVH 2048

  Fly  2009 LRKYNLRRSALEIFLVDQTSYFLNF------------------------------TTKTRNKVFT 2043
            ||:|||||||||:|.:||:.||:||                              ..:.||||::
Zfish  2049 LRRYNLRRSALELFFIDQSHYFINFRKGVRHLDRHKQRKTRVSSTPICVFIFVFILPQVRNKVYS 2113

  Fly  2044 KIVGLPLPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWI 2108
            :|:||..||:.|...|||.|||:||.||.||:.||||||||||.|||||||:||||||||||||:
Zfish  2114 RILGLRPPNLFYFGSRSPQELLKASNLTHRWVCREISNFEYLMQLNTIAGRTYNDLSQYPVFPWV 2178

  Fly  2109 LADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVL 2173
            |.||||..|||.||..|||||||||.:||::...||.||:|||||:|.|.||||||||||:|||:
Zfish  2179 LCDYTSAELDLDDPAVFRDLSKPIGVVNPRHAQNVREKYESFEDPTGTIDKFHYGTHYSNAAGVM 2243

  Fly  2174 HYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKF 2238
            ||::|.||||||||.||||:||.||||||||...|:..|::|.||||||||||||||||:|||.|
Zfish  2244 HYMIRTEPFTSLHIQLQSGKFDCADRQFHSIAAAWQARMESPADVKELIPEFFYFPEFLENMNGF 2308

  Fly  2239 DLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEAL 2303
            |||.|||::|||::|:||.||::.|:||..||:|||||:||.|||.||||||||||:||:|.|||
Zfish  2309 DLGCLQISQEKVNNVLLPPWASSREDFIRKHRKALESEHVSAHLHEWIDLIFGYKQRGPEAVEAL 2373

  Fly  2304 NVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRR 2368
            ||||||:||||||||.|.|..||:|:||:|:||||.|.|||:||||.|::.:....:..|.::..
Zfish  2374 NVFYYCTYEGAVDLDAIANETERKALEGIISNFGQTPCQLLKEPHPPRMSAENAFRRAARLDILP 2438

  Fly  2369 PDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPPRSFLQLSPDVLVSISKSTILGCNSWLSFDKD 2433
            |:|...|.| ::.:.|:.:....:|....||:..|||:....|:||::|.:.::|.:|||.:||:
Zfish  2439 PNLFDQLSK-LRSFKEVVSDGLALVQAVVPRNQTRSFIIPGSDILVTVSANGMIGTHSWLPYDKN 2502

  Fly  2434 --QGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGK 2496
              ..|....|.:.:|.|.::.:.|||....:..||:..||:||:||::||.||.||||..|.|.|
Zfish  2503 IANYFTFTRDPSVSNPKTQRFLSGPFSPGVEMGSQVLVVSSDGRLLFSGGHWDCSLRVTMLGKAK 2567

  Fly  2497 AVASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAI 2561
            .|..:.||:|::||:|||.||.||::||||.||:||  |..||||.|                  
Zfish  2568 LVGRICRHIDVVTCLALDLCGIYLISGSRDTTCMVW--QVLQQGGFS------------------ 2612

  Fly  2562 TQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCT 2626
                  :..||:|:.||.|||..::.|||.||||:.:|||.||||.|::::.||::.||:| .| 
Zfish  2613 ------SGLSPRPIQVLCGHDQEVTCVAISTELDMAISGSKDGTVIVHSVRRGQYLWTLRP-PC- 2669

  Fly  2627 ESCVQ--ISFVTLSYHGHIAF-SALDDTS-----HSVHVYSINGCSLGSKYVSGRVTGLASASDY 2683
            |:||.  ::.:.:...|||.. :.|:..|     :::||||:||..|.|:.:..:::.|....||
Zfish  2670 ENCVSAPVAQLEVGMEGHIVMQTVLEGRSAGKERYALHVYSVNGTLLASETLDEKISALYLVPDY 2734

  Fly  2684 LVVADDAGDITMSRLHGLK-PVFDIPLHVPIQTVVVTPGNTHILAPLRDGRLAVIAVQLP 2742
            |:|....|::.:..|:.|. .|..:.|.||::.|.||..::|||..|.||:|.|:....|
Zfish  2735 LIVGTQQGNLHIRDLYSLNLAVAPLALKVPVRCVSVTKESSHILVGLEDGKLIVVGAGKP 2794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 41/126 (33%)
DUF4704 906..1162 CDD:292415 79/258 (31%)
DUF4800 1650..1899 CDD:292675 74/255 (29%)
PH_BEACH 1952..2046 CDD:275391 50/126 (40%)
Beach 2072..2351 CDD:280327 203/278 (73%)
WD40 <2428..2734 CDD:225201 122/316 (39%)
WD40 repeat 2465..2503 CDD:293791 20/37 (54%)
WD40 2468..2687 CDD:295369 93/226 (41%)
WD40 repeat 2509..2580 CDD:293791 28/70 (40%)
WD40 repeat 2585..2621 CDD:293791 18/35 (51%)
nbeal2XP_009290461.1 DUF4704 915..1173 CDD:292415 80/265 (30%)
DUF4800 1680..1938 CDD:292675 75/264 (28%)
PH_BEACH 1989..2078 CDD:275391 46/88 (52%)
Beach 2143..2421 CDD:280327 203/277 (73%)
WD40 <2442..2814 CDD:225201 141/382 (37%)
WD40 2536..2817 CDD:295369 115/287 (40%)
WD40 repeat 2580..2625 CDD:293791 28/70 (40%)
WD40 repeat 2630..2666 CDD:293791 18/35 (51%)
WD40 repeat 2672..2706 CDD:293791 7/33 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 463 1.000 Domainoid score I456
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1456 1.000 Inparanoid score I111
OMA 1 1.010 - - QHG47730
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 1 1.000 - - FOG0003051
OrthoInspector 1 1.000 - - otm25142
orthoMCL 1 0.900 - - OOG6_101577
Panther 1 1.100 - - LDO PTHR13743
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.980

Return to query results.
Submit another query.