DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ero1L and ERO2

DIOPT Version :9

Sequence 1:	NP_647865.2	Gene:	Ero1L / 38500	FlyBaseID:	FBgn0261274	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001189708.1	Gene:	ERO2 / 818481	AraportID:	AT2G38960	Length:	479	Species:	Arabidopsis thaliana

Alignment Length:	475	Identity:	167/475 - (35%)
Similarity:	239/475 - (50%)	Gaps:	85/475 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ASAAVVL-VLLLLWTDTTGGYFAAIDETETSKNCFC------ELEGSINDCSCDVDTVDHFNNMK 69
            |.|||:| |::.::.:|..   ::|.|. |.|.|.|      :..|.:.||.||.:||:..|...
plant    26 AIAAVLLAVVVAVFLNTQN---SSISEF-TGKICNCRQAEQQKYIGIVEDCCCDYETVNRLNTEV 86

  Fly    70 IYPRLQSLLVKNFFRFYKVNLRQECPFWPDDSRCAMRFCQVENCEEQAIPQGIKDKGEHKEKAAF 134
            :.|.||.|:...|:|::||.|..:|||||||..|.:|.|.|..|.|...|:..|       |...
plant    87 LNPLLQDLVKTPFYRYFKVKLWCDCPFWPDDGMCRLRDCSVCECPESEFPEVFK-------KPLS 144

  Fly   135 KYTREAQVGGSACSDGEDFDSSLGFLDTSISDQAHREFEL----WAKHDEAEEDFCIVDDHEEGS 195
            :|       ...|.:|:    ....:|.::..:|.|.:.:    |...||.:.|         ..
plant   145 QY-------NPVCQEGK----PQATVDRTLDTRAFRGWTVTDNPWTSDDETDND---------EM 189

  Fly   196 QYVDLLLNPERYTGYKGESAHRIWKSIYLENCFGGNNETANKFSNYVPHLDLRNVCLEQRAFYRI 260
            .||:|.|||||||||.|.||.|||::||.|||               |.......|.|::..|::
plant   190 TYVNLRLNPERYTGYIGPSARRIWEAIYSENC---------------PKHTSEGSCQEEKILYKL 239

  Fly   261 ISGLHSSINIHLCSKYLLSESKDFLDPQGIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIYLIE 325
            :|||||||::|:.|.|||.|:.:      :||.|:.....|..      ..|..::||||.:|..
plant   240 VSGLHSSISVHIASDYLLDEATN------LWGQNLTLLYDRVL------RYPDRVQNLYFTFLFV 292

  Fly   326 LRALAKAAPYLRREDYYTGIAEEDDEVKLAINDMLSVIENFQS---HFDENALFSNGIASIKFKH 387
            |||:.||..||...:|.||...||.:.|..:..::|..:...:   .|||..|: .|....:.|.
plant   293 LRAVTKAEDYLGEAEYETGNVIEDLKTKSLVKQVVSDPKTKAACPVPFDEAKLW-KGQRGPELKQ 356

  Fly   388 DYKEKFRNISRIMSCVGCDKCKLWGKLQTQGLGTALKILYSEKLNLATESGLWDKPHIEADPIFR 452
            ..:::|||||.||.||||:||:||||||..|||||||||::    :..|..|  :.::|
plant   357 QLEKQFRNISAIMDCVGCEKCRLWGKLQILGLGTALKILFT----VNGEDNL--RHNLE------ 409

  Fly   453 LSRTEIVALFNAFGRLSNSI 472
            |.|.|::||.|...|||.|:
plant   410 LQRNEVIALMNLLHRLSESV 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ero1L	NP_647865.2	ERO1	69..473	CDD:282050	146/411 (36%)
ERO2	NP_001189708.1	ERO1	87..430	CDD:282050	146/410 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	234	1.000	Domainoid score	I630
eggNOG	1	0.900	-	-		E1_COG5061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I970
OMA	1	1.010	-	-		QHG54085
OrthoDB	1	1.010	-	-		D1181226at2759
OrthoFinder	1	1.000	-	-		FOG0001495
OrthoInspector	1	1.000	-	-		otm2876
orthoMCL	1	0.900	-	-		OOG6_101008
Panther	1	1.100	-	-	LDO	PTHR12613
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1065
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840