DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ero1L and Ero1a

DIOPT Version :9

Sequence 1:	NP_647865.2	Gene:	Ero1L / 38500	FlyBaseID:	FBgn0261274	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_056589.1	Gene:	Ero1a / 50527	MGIID:	1354385	Length:	464	Species:	Mus musculus

Alignment Length:	460	Identity:	223/460 - (48%)
Similarity:	302/460 - (65%)	Gaps:	47/460 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SKNCFCELEGSINDCSCDVDTVDHFNNMKIYPRLQSLLVKNFFRFYKVNLRQECPFWPDDSRCAM 105
            ::.|||::.|.::||:|||:|:|.|||.:::||||.||..::||:|||||::.||||.|.::|..
Mouse    32 AQRCFCQVSGYLDDCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLKKPCPFWNDINQCGR 96

  Fly   106 RFCQVENCEEQAIPQGIKDKGEHKEKAAFKYTREAQVGGSACSDGEDFDSSLGFLDTSISDQAHR 170
            |.|.|:.|....:|.|||       .|::||:.||. ....|...|    .||.:|.|:|::..:
Mouse    97 RDCAVKPCHSDEVPDGIK-------SASYKYSEEAN-RIEECEQAE----RLGAVDESLSEETQK 149

  Fly   171 EFELWAKHDEAEEDFCIVDD-HEEGSQYVDLLLNPERYTGYKGESAHRIWKSIYLENCF------ 228
            ....|.|||::.:.||.:|| ....::||||||||||||||||..|.|||..||.||||
Mouse   150 AVLQWTKHDDSSDSFCEIDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQ 214

  Fly   229 -----GGNNETANKFSNYVPHLDLRNVCLEQRAFYRIISGLHSSINIHLCSKYLLSESKDFLDPQ 288
                 |......|.|.|:     |..:|:|:|||||:|||||:|||:||.::|||.::  :|:.:
Mouse   215 RPLASGRGKSKENTFYNW-----LEGLCVEKRAFYRLISGLHASINVHLSARYLLQDT--WLEKK 272

  Fly   289 GIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIYLIELRALAKAAPYLRREDY--YTGIAEEDDE 351
              ||.||.||::||....|.||||..||||||:||||||||:|..|:..|.|:  :||...:|.|
Mouse   273 --WGHNVTEFQQRFDGILTEGEGPRRLRNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDAE 335

  Fly   352 VKLAINDMLSVIENFQSHFDENALFS-NGIASIKFKHDYKEKFRNISRIMSCVGCDKCKLWGKLQ 415
            .|..:.::|..|::|..|||||:.|: :...:.|.|.|::..||||||||.||||.||:||||||
Mouse   336 NKALLLEILHEIKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQ 400

  Fly   416 TQGLGTALKILYSEKL--NLATESGLWDKPHIEADPIFRLSRTEIVALFNAFGRLSNSIYEMENF 478
            |||||||||||:||||  |: .|||    |..|    |:|:|.|||:|||||||:|.|:.|:|||
Mouse   401 TQGLGTALKILFSEKLIANM-PESG----PSYE----FQLTRQEIVSLFNAFGRISTSVRELENF 456

  Fly   479 RCVLR 483
            |.:|:
Mouse   457 RHLLQ 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ero1L	NP_647865.2	ERO1	69..473	CDD:282050	203/420 (48%)
Ero1a	NP_056589.1	ERO1	60..451	CDD:282050	203/420 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850165
Domainoid	1	1.000	373	1.000	Domainoid score	I885
eggNOG	1	0.900	-	-		E1_COG5061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1814
Isobase	1	0.950	-	0	Normalized mean entropy	S2105
OMA	1	1.010	-	-		QHG54085
OrthoDB	1	1.010	-	-		D1181226at2759
OrthoFinder	1	1.000	-	-		FOG0001495
OrthoInspector	1	1.000	-	-		otm42936
orthoMCL	1	0.900	-	-		OOG6_101008
Panther	1	1.100	-	-	O	PTHR12613
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R413
SonicParanoid	1	1.000	-	-		X1065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750