DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ero1L and ero11

DIOPT Version :9

Sequence 1:	NP_647865.2	Gene:	Ero1L / 38500	FlyBaseID:	FBgn0261274	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001342754.1	Gene:	ero11 / 2540901	PomBaseID:	SPBC4F6.16c	Length:	467	Species:	Schizosaccharomyces pombe

Alignment Length:	478	Identity:	134/478 - (28%)
Similarity:	203/478 - (42%)	Gaps:	134/478 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IDETETSKNCFCELEGSINDCSCDVDTVDHFNNMKIYPRLQSLLVKNFFRFYKVNL-RQECPFWP 98
            |.:|:||.....:::..:.               .:.|.|...  .::|.:|:||| |..||.|.
pombe    25 ISQTDTSSTGIYQMQSKVR---------------SLVPVLTER--SDYFSYYRVNLYRSSCPLWE 72

  Fly    99 -DDSRCAMRFCQVENCEEQAIP---QGIKDKGEHKEKAAFKYTREAQVGGSACSDGEDFDSSLGF 159
             |::.|:.:.|.|::..|..||   :.:.|...|.:|.
pombe    73 NDNAMCSNQGCAVKSLNEIEIPKVWKKLSDFEPHSKKN--------------------------- 110

  Fly   160 LDTSISDQAHREFELWAKHDEAEEDFCIVDDHEEGSQ--YVDLLLNPERYTGYKGESAHRIWKSI 222
             ||..:         |..:.:.  |:|.:|:.....:  ||.|:.||||:|||.|:.:..||:||
pombe   111 -DTKCN---------WKYNPDL--DYCYLDNSTSPDEYVYVSLVQNPERFTGYAGDHSAAIWRSI 163

  Fly   223 YLENCF---GGNNETANKFS------NYVP-HLDLRN----------VCLEQRAFYRIISGLHSS 267
            |.:|||   ..:|.:....|      |.:| :|...|          .|||:|.|.|||||.|:|
pombe   164 YEQNCFVVDDDDNPSEQPKSNALFRPNQIPLNLFTENHDDTSLSPSVACLEKRMFNRIISGFHAS 228

  Fly   268 INIHLCSKYLLSESKDFLDPQGIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIYLIELRALAKA 332
            |:.|:|..|...|.:.:......|...|..|             |..:.|::|.|.:..:||.:.
pombe   229 ISTHVCQNYYDVEEQRWTQNLDWWRAKVGSF-------------PDRIENIFFNYALLHQALVQI 280

  Fly   333 APYLRR---EDYYTGIAEEDD---EVKLAINDML-------SVIENFQSHFDENALFSNGIASIK 384
            |..::.   :..:|....:.|   ....|...::       .||...|...||.|.        :
pombe   281 ATQMKNITSDSSFTFCPTDKDVDWRTHTAFEQLVYHAYQDRHVINREQFFADEEAK--------R 337

  Fly   385 FKHDYKEKFRNISRIMSCVGCDKCKLWGKLQTQGLGTALKILYSEKLNLATESGLWDKPHIEADP 449
            ||..:::.||:|||||.|||||||:||||:|..|.|||||:|      |..|:.|.|
pombe   338 FKDSFRKHFRDISRIMDCVGCDKCRLWGKVQITGYGTALKLL------LEPETQLSD-------- 388

  Fly   450 IFRLSRTEIVALFNAFGRLSNSI 472
               |...|:|||.|.|.|:|:|:
pombe   389 ---LRPEEVVALVNTFDRISHSV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ero1L	NP_647865.2	ERO1	69..473	CDD:282050	130/444 (29%)
ero11	NP_001342754.1	ERO1	1..467	CDD:227393	134/478 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54085
OrthoFinder	1	1.000	-	-		FOG0001495
OrthoInspector	1	1.000	-	-		otm47150
orthoMCL	1	0.900	-	-		OOG6_101008
Panther	1	1.100	-	-	O	PTHR12613
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R413
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.810