DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mas and ndl

DIOPT Version :9

Sequence 1:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster

Alignment Length:	1212	Identity:	266/1212 - (21%)
Similarity:	387/1212 - (31%)	Gaps:	446/1212 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 KNATAVRATTTP----KTTTTASTTTTQR----TTTTVATTSTTKRTTTTSTT------PKPKPK 144
            :|.|...|::.|    :.|.:....||:.    ..||.....|||.|.....:      .:...:
  Fly   346 RNVTTTSASSEPIVDTENTNSDHVPTTENGLVFNITTDGPVETTKSTAQRKLSFDWILDGEENVE 410

  Fly   145 PQTKRPATSSTTKATVATTKKPSTTKKVATAKPK-------DKEEATKADDANKDCTGVCVADRI 202
            |:.|...|::||.|| .||...|.|..|.|..||       |..|..:..:...:.||
  Fly   411 PEVKSTNTTTTTAAT-TTTGATSETIIVTTELPKITFDWIIDGREVVEPQETTTEVTG------- 467

  Fly   203 AEYCEAYLTSDGLCKEGTKCCVSLDEYSNGKLPKDIYIPAKHMSNLKPNQTLSEKSAPAKSSSTS 267
                    |::.|                .|:|.|..|..:            |...|.::.:|:
  Fly   468 --------TTERL----------------RKMPFDWIIDGE------------EVVEPQENVTTT 496

  Fly   268 TTSTTTTTSTTTTPEPARINNSSPKPTKHK----------------------KHPTTTTTEAA-- 308
            |.:||...|||...|  ||:||:..|||.|                      ..|..||.||.
  Fly   497 TIATTVAVSTTEINE--RIHNSTAYPTKPKPVKFDWIIDGGESSGEVSTSSTSQPKLTTREAISN 559

  Fly   309 -----------------------EEEEEQ--------------ETEEDG----------EEEEPP 326
                                   |:.|||              ||..||          |::..|
  Fly   560 PESPRSSHPLDNPTSIENMLESFEQHEEQKPILRVLNANESSSETVTDGYERQLWLKKFEDQARP 624

  Fly   327 LSNKL--------------KSG------------QGQGQVLKECEGEC--MNGIFAIFCDDIDSD 363
            ..|:|              |.|            ....|:|..||...  |....|...|
  Fly   625 NQNELIDTFGTALDAKALDKMGPKINPLNGHTWNAADAQILSLCERVALRMRNKVATMSD----- 684

  Fly   364 AFCPGEESCCVTGGASEATPS----SKAPPTKPAIKHAPKPAAK---------PARP-------- 407
                ||..  ..|....|:||    |:||...|......|.:|:         |:.|
  Fly   685 ----GETK--EKGETFTASPSVQFTSRAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCFYMTPA 743

  Fly   408 -----------------------ASPPPA---------PPSST----SGGGGGGDFLSQIISFAE 436
                                   :|.|.|         .||..    |||.|.|...:.|.|
  Fly   744 NFRMPMWSNTPTFMGMQGAHFGGSSNPGAGIFFVPQQFGPSGNFFGGSGGSGAGGQGANIFS--- 805

  Fly   437 STLNSPSPPPPPPQAPIQVPRCPGFCLLNIMAAFCERPSVLVSTPTTCAKGSVCCDNSRAGAPKP 501
                ..:.|..|.....||              :|   |.:.:.....|..|......:.|....
  Fly   806 ----KNASPQKPTNGQQQV--------------YC---SYMQNQSGQGAGQSQTSSQQQQGGQSA 849

  Fly   502 ------KLPPPTPSPTASPTA----PPYV-LPNTPSPDPREECPGSCIVSLLSFTCFKNAEMTDL 555
                  |:.....:.||:...    ..|. ||..|..: |..||...     .|:||...|....
  Fly   850 FSNANFKMRHANQTNTANQQGQIIYASYAGLPQQPIQE-RSRCPEPD-----QFSCFGQQECIPA 908

  Fly   556 FR-CKR-------SGQICCAPKSKILEKQQFQTRNDTAYYPAPPPPPIGPPQ--AYPPQTPPYSY 610
            .| |..       |.:..|....::.|::......|.         |:|..:  .:..::..||.
  Fly   909 ARWCDNVVDCSDGSDESACTCADRVDEERLCDGYEDC---------PMGEDELGCFGCESLAYSC 964

  Fly   611 MNNPPP--------------------------QGPPPQ--------MAPH--HPNPYQPPPPAPN 639
            ..||..                          .|...:        :|.|  |...........|
  Fly   965 YENPQDFAKRNRSTISMCYSRLERCDGFMNCLNGRDEEQCSMLVTDVADHMSHGASASEGYLYHN 1029

  Fly   640 Y-ADYYPVSGPG-----LPPQPQPPMTTPPTTT-----TTTTTPRPHVYSKYVCGVKGTLRTGRS 693
            | .|::||...|     |..|.........:.:     .|.|.|.|.        ::.:|..|
  Fly  1030 YRGDWHPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPF--------IEPSLHAG-- 1084

  Fly   694 QALSFVSYARAKYGVQRTARQMTSAAGYSPNFNKSNERLVLGSAIV---PIQIHNDKLGDLVESS 755
                 |.:|:|.:|                  ..|::.||...|.|   |:|     .|...:||
  Fly  1085 -----VHFAQACHG------------------RNSHDSLVDHVAYVKCPPMQ-----CGLPSKSS 1121

  Fly   756 SLQ-SNQLRSYHNHQAQADQPDLVYPEYYQQRSLYGLQSNFSGRRRARVVGGEDGENGEWCWQVA 819
            .|: |.::|     :|.:|..::|                    ...|:|||......:|.:.||
  Fly  1122 MLEHSKRVR-----RAVSDSKEIV--------------------GDGRIVGGSYTSALQWPFVVA 1161

  Fly   820 LINSLNQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIY-VRVGDYDLTRKYGSPGAQTLRVATTY 883
            :..: .::.||..:...:|:::|||||.|.   |...| ||.|  .|.|...||..|...|:...
  Fly  1162 IYRN-GKFHCGGTIYSDRWIISAAHCVINY---GKYFYEVRAG--LLRRSSYSPATQIQPVSHVV 1220

  Fly   884 IHHNHNSQTLDNDIALLKLHGQAELRDGVCLVCLPARG------------VSHAAGKRCTVTGYG 936
            :|..:..:::.||::||:|....:....|..:|||.:|            |.|..   |||.|:|
  Fly  1221 VHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTL---CTVVGWG 1282

  Fly   937 YMGEAGPIPLRVREAEIPIVSDTECIRKVNAVTEKIFILPASSFCAGGEE-GHDACQGDGGGPLV 1000
            .:.|.||....:|:..:||  ..:|....:..:|.|        |||..: |.||||||.||||.
  Fly  1283 AIREKGPSSDPMRQVIVPI--RKKCTDPEDQASEDI--------CAGDPDGGRDACQGDSGGPLF 1337

  Fly  1001 CQD----DGFYELAGLVSWGFGCGRQDVPGVYVKTSSFIGWI 1038
            |:.    |.|| |||:||.|.||.|....|||.:.:.::.|:
  Fly  1338 CRSVSNPDEFY-LAGVVSHGNGCARPQEFGVYTRVTLYLDWL 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	84/254 (33%)
ndl	NP_523947.2	LDLa	891..927	CDD:238060	9/40 (23%)
		Tryp_SPc	1144..1377	CDD:214473	84/252 (33%)
		Tryp_SPc	1145..1379	CDD:238113	84/254 (33%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24258
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100