DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mas and flz

DIOPT Version :9

Sequence 1:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster

Alignment Length:	1392	Identity:	290/1392 - (20%)
Similarity:	454/1392 - (32%)	Gaps:	496/1392 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 TTTASTTTTQ--RTTTTVATTSTTKRTTTTSTTPKPKPKPQTKRPATSSTTKATVATTKKPS--- 167
            ||...|..|.  :..|:..:.|..:.::|.:.|.|||||| |:.|...:|.|||...|.||:
  Fly   342 TTEVPTKITSGLQDQTSSESNSFEEVSSTPAATQKPKPKP-TQMPTQKTTQKATQKPTPKPTQKA 405

  Fly   168 ----------TTKKVATAKP----KDKEEATKADDANKDCTGVCVADRIAEYCEAYLTSDGLCKE 218
                      :.|:....||    |.|.....|...|.......:.|. .|:..:.:|..|...:
  Fly   406 KPKPVPQLAESMKRPIQQKPQQVAKPKPSPKPAQSTNNHHHNHLILDG-GEFTHSDITHPGADAD 469

  Fly   219 GTKCCVSLDEYSNGKLPKDIYI-PAKHMSNLKP-NQTLSEKSAPAKSSSTSTTSTTTTTSTTTTP 281
                .|...::|.|..|:.:|. |.|.....:| .|:....|..||..:|...|.||.:|.||..
  Fly   470 ----LVEDLQFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSSTSAKRPTTGHNSPTTVSSITTHV 530

  Fly   282 EP-----ARINNSSPKPTKH----------------------KKHPT------------------ 301
            :.     .::||:|..|:.:                      .::||
  Fly   531 DSIESIILQLNNTSHGPSYNVVSQQTPSYGYPGAAVVQTEPAAQNPTFYQENESEKVQESDSQSD 595

  Fly   302 ---TTT----------------TEAAEEEEEQET------------------------------- 316
               |||                :.|..:..|..|
  Fly   596 YGYTTTVNYESFYDKVSDEQDASAAVSQSAEMPTARPGYGEDVSAVLEDHTMPANGYHDAEAPVA 660

  Fly   317 -----------------------EEDG---------------------------------EEEEP 325
                                   ||:|                                 ||.:|
  Fly   661 PQTSEFNKMPVMGIAYPVDMSYMEEEGNLPATAAGYGQMSSDSYEASTESTYQKLSTVQTEEPQP 725

  Fly   326 ----PLSNKLK----------------------SGQGQGQV------------LKECEGECMNGI 352
                |.:|..|                      :|..|.||            ::|...|..||.
  Fly   726 TYVRPTTNANKQNRPVASYIGMVTMQHYNPQPGNGDYQAQVPPEVSVSSHTTKVQEQMDETSNGY 790

  Fly   353 -------------FAIFC-------DDIDSDAFCPGEESCCVTGG-ASEATPSSKAPPTKPAI-- 394
                         .|:..       |.:..||  ..|....||.. .....||:|.|..|..|
  Fly   791 QQSETTSGYVSPPTAVPAPAQRPQYDAVQGDA--SSERPVLVTASPRPRPKPSTKRPAVKRPISG 853

  Fly   395 -----KHAPKPAA-----------------------------------KPA-------------R 406
                 |..|:|:|                                   ||:             |
  Fly   854 ESTKKKPQPQPSAGAYNQEKISEHSTRKPVSNGYDKVPESPITHIQIKKPSATQHKEQEQTGYPR 918

  Fly   407 PASP----------------------PPAPPS---STSGGGGGGDFLSQI--ISFAESTLNSP-- 442
            ||||                      |.||||   ..|......|.|:.:  :::.|...:||
  Fly   919 PASPAGYEQTTAAAPAPAAPSLNYDKPDAPPSQYDQPSAPSASYDQLAPMPSLNYNEQHASSPGR 983

  Fly   443 --------------SPPPPPPQAPI-----QVPRCPGFCLLNIMAAFCE--RPSVLVSTPTTCAK 486
                          .|..|.|.|.:     .||  |.|...:.:.||.:  ..:::.|||.....
  Fly   984 KPSTAKPISTSYVTGPSTPRPPATVDYHYDNVP--PLFMADDKLDAFIQSTAENIVGSTPGNYQP 1046

  Fly   487 GSVCCDNSRAGAPKPKLPPPTPSPTASPTAPPYVLPN-TPSPDPREE---CPGSCIVSLLSFTCF 547
            ..|...::.|.|.:     ||.|.:.....|.:|..| ||.| ||..   .|....::|::::..
  Fly  1047 PLVATASTPAYAHR-----PTSSGSYGHKKPGFVQINGTPKP-PRPTVLITPKPTAINLVTYSSL 1105

  Fly   548 KNAEMTDLFRCKRSGQICCAPKSKILEKQQFQTRNDTAYYPAPP--------------------- 591
              ::.::......|..:...|..:.:....|:   |..|:.:.|
  Fly  1106 --SDDSNKLASSTSSYVTGRPGVQGVSSNDFK---DPGYFGSSPVHVAFTQSTTEAVYAVPSDDK 1165

  Fly   592 ---PPPIGPPQAYP----------------PQTPPYSYMNNPPPQGPPPQMAP------------ 625
               |...||..:||                ..|.|..::|.||.:.|...|:.
  Fly  1166 PAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLS 1230

  Fly   626 ------------------HH------------PNPYQPPPPAPNYADYYPVSGPGLPPQPQPPMT 660
                              |.            .:..:.|......|.|.  :|.|...:|...:|
  Fly  1231 TPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQ--AGAGGTAKPVRVVT 1293

  Fly   661 TPPTTTTTTTTPRPHVYSKYVCGVKGTLRT---GRSQALSFVSYARAKYGVQRT--ARQMTSAAG 720
            |.....|.||| ||.|.:|     |...|.   ..::..|.||....|...:||  |.::|:..
  Fly  1294 TRKPVRTATTT-RPKVTTK-----KPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTTT- 1351

  Fly   721 YSPNFNKSNERL---VLGSAIVPIQIHNDKLGDLVESSSLQSN----------QLRSY------- 765
            ..|...|...|:   |..:.:...:..:|::.|..:...:..|          .|.||
  Fly  1352 RRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRK 1416

  Fly   766 -HNHQAQADQPDLVYPEYYQQRSLYGLQSNFSGRRRARVVGGEDGENGEWCWQVALINS-----L 824
             |:.......|:|.   ::...:..|::.:.   :..|:|||:....|.:.|||.:..|     .
  Fly  1417 IHSTSRTLPTPNLA---FHSPSTECGVRPHV---KSGRIVGGKGSTFGAYPWQVLVRESTWLGLF 1475

  Fly   825 NQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDYDLTRKYGSPGAQTLRVATTYIHHNHN 889
            .:..||..||.:::|:|||||....:.|..|:   :|::|::....|..:.|..|....:|..::
  Fly  1476 TKNKCGGVLITSRYVITAAHCQPGFLASLVAV---MGEFDISGDLESKRSVTKNVKRVIVHRQYD 1537

  Fly   890 SQTLDNDIALLKLHGQAELRDGVCLVCLPARGVSHAAGKRCTVTGYGYMGEAGPIPLRVREAEIP 954
            ..|.:||:|||:|....:....:..:|:| ..|:...|:..||||:|.:...|.:|..::|.::|
  Fly  1538 PATFENDLALLELDSPVQFDTHIVPICMP-NDVADFTGRMATVTGWGRLKYGGGVPSVLQEVQVP 1601

  Fly   955 IVSDTECIRKVNAVTEKIFILPASSFCAGGEEGH-DACQGDGGGPLVCQ-DDGFYELAGLVSWGF 1017
            |:.::.|....:.......|| .|..|||...|. |:|:||.|||||.| .||.|||||.||.|.
  Fly  1602 IIENSVCQEMFHTAGHNKKIL-TSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGI 1665

  Fly  1018 GCGRQDVPGVYVKTSSFIGWINQIISV 1044
            .|....:||||::|:.:..|:..|..|
  Fly  1666 KCAAPYLPGVYMRTTFYKPWLRSITGV 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	82/244 (34%)
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862	30/110 (27%)
		PRK11633	<365..>439	CDD:236940	22/74 (30%)
		PRK10263	<547..>1005	CDD:236669	63/459 (14%)
		PHA03247	<792..1096	CDD:223021	63/313 (20%)
		Tryp_SPc	1449..1689	CDD:238113	82/244 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910