DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mas and svh-1

DIOPT Version :9

Sequence 1:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_501379.2	Gene:	svh-1 / 182375	WormBaseID:	WBGene00006620	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	1128	Identity:	231/1128 - (20%)
Similarity:	371/1128 - (32%)	Gaps:	363/1128 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SLAGSFLSGLLDTITSTADSKDCPGVCVHTLATLICYEVLDD-------VACPSPSMKCCIENAP 91
            |::.:|||....::.....|..|        .|.:|:..|..       |.| |||: |......
Worm    65 SISSTFLSYSTVSLQQYTYSVGC--------TTSVCFTFLSSFCKTGVKVFC-SPSL-CASGTLQ 119

  Fly    92 AGKNATAVRATTTPKTTTTASTTTTQRTTTTVATTSTTKRTTTTSTTPKPKPKPQTKRPATSSTT 156
            .|....::            ||...|..:.  |.......|..:|..|       |:..:...|.
Worm   120 IGSKCLSI------------STVPVQGYSE--ANYYCNPATLISSLKP-------TEIESIRDTI 163

  Fly   157 KATVATTK--KPSTTKKVATAKPKDKEEATKADDANKDCTGV--CVA----DRIAEYC--EAYLT 211
            ..|.|.|:  ..|..::.||.|      ....|...::.||.  |:|    :.:|..|  |||:
Worm   164 LPTFADTRLFLTSGLRQGATWK------WGNGDTVEQEVTGTGRCLALQAGNLVAIDCDSEAYV- 221

  Fly   212 SDGLCKEGTKCCVSLDEY-------SNGKL------PKDIYIPAKHMSNLKPNQTLSEKSAPAKS 263
               .|:.|.:|.....||       |:||:      |..::...:.:..|..|.......|..|.
Worm   222 ---FCESGRECIARDKEYSGTANRTSDGKMCLMWNDPTVLFRRERDLEILNHNFCRFVNDADGKK 283

  Fly   264 SSTST--TSTTTTTSTTTTPEPARIN--------NSSPKPTKHKKHPTTTTTEAAEEEEEQETEE 318
            |:|..  |.....:.....|.|...|        :|.|..:....:.:...:|..:.:.|.:. .
Worm   284 SATPVCYTKPNELSQCYIPPCPESFNDVVPIESGDSCPIGSISCDNGSKCISEKFQCDYEVDC-N 347

  Fly   319 DGEEEEPPLSNKLKSGQGQGQVLKECEGEC----MNGIFAIFCDDIDSDAFCPGEESCCVTGGAS 379
            ||.:|.                  .||...    :.|.:.:..:.|:...|.|..:.|
Worm   348 DGSDEH------------------NCEDYLQYYELIGAYRLADNIIEVWTFIPHVQGC------- 387

  Fly   380 EATPSSKAPPTKPAIKHAPKPAAKPARPASPPPAPPSSTSGGGGGGDFLSQIISFAESTLNSPSP 444
             |....::.....|..:.||                |.|.           :::....|.:|
Worm   388 -ARKCRESLLMCEAFSYEPK----------------SQTC-----------LLTDTSQTFSS--- 421

  Fly   445 PPPPPQAPIQVPRCPGFCLLNIMAAFCER------------PSVLVSTPTTCAKGSVCCDN-SRA 496
                             ....|.:.:..|            ..||.:| .:..||.||.|| ||.
Worm   422 -----------------LARKITSLYYRRRFSTKDVEFQVENKVLYAT-KSAKKGHVCDDNYSRE 468

  Fly   497 -----------GAP---------KPKLPPPTPSPTASPTAPPYVLPNTPSPDPREECPGSCIVSL 541
                       |.|         :..|.|..|: |..||.|.:..|::.| ..|...|.:.:...
Worm   469 KLSSICRVLGFGDPIYTVESHQSESSLGPLQPT-TLHPTNPSFDSPSSVS-QMRRTSPSATLAPR 531

  Fly   542 L---SFTCFKNAEMT-------DLFRCKRSGQICCAPKSKILEKQ------QFQTRNDTAYYPAP 590
            |   :.:|.:....|       :..||....|..|...|.|...|      ..|:..|..|..|
Worm   532 LPAWNLSCLREPNCTSTVISTCEPIRCSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRA- 595

  Fly   591 PPPPIGPPQAYPPQTPPYSYMNNPPPQGPPPQMAPHHPNPYQPPPPAPNYAD------YYPVSGP 649
                           ..:...|.....|                     |.:      :.|:..
Worm   596 ---------------NSFRLTNGSDTSG---------------------YLEVLFRSRWEPICA- 623

  Fly   650 GLPPQPQPPMTTPPTTTTTTTTPRPHVYSKYVCGVKGTLRTGRSQALSFVSYARAKYGVQRTARQ 714
                                    .|:..|....:...:|.|..   .|:....|
Worm   624 ------------------------DHLNGKISNSICDAMRLGEH---GFILSTNA---------- 651

  Fly   715 MTSAAGYSPNFNKSNERLVLGSAIVPIQIHNDKLGDLVESSSLQSNQLRSY-------HNHQAQA 772
             |.::||:.|.:                         |:.|..:|:....:       .|..:.|
Worm   652 -TISSGYNVNCD-------------------------VDCSIRRSSSCTRHARISCISQNGMSSA 690

  Fly   773 DQPDLVYPEYYQQRSLYGLQSNFSGRRRARVVGGEDGENGEWCWQVALINSLNQ-YLCGAALIGT 836
            .|..|.|.|...:        :.:..|.||||||.:...|.:.|..||.|...: :.|||:::..
Worm   691 SQCGLRYVEVNAR--------DAAKSRIARVVGGFETVPGAFPWTAALRNKATKAHHCGASILDK 747

  Fly   837 QWVLTAAHCVTNIVRSGDAIYVRVGDYDLTRKYGSPGAQTLRVATTYIHHNH----NSQTLDNDI 897
            ..::|||||.....|. .:..|.|||:|..:..|:.       ...|:...|    ......:||
Worm   748 THLITAAHCFEEDERV-SSYEVVVGDWDNNQTDGNE-------QIFYLQRIHFYPLYKDIFSHDI 804

  Fly   898 ALLKL-HGQAELRDGVCLVCLPARGVSHAAGKRCTVTGYGYMGEAGPIPLRVRE----AEIPIVS 957
            |:|:: :...|..:....:|||::...:..|::|.|:|:|.||      ||..|    |.|||::
Worm   805 AILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWGSMG------LRYAERLQAALIPIIN 863

  Fly   958 DTECIRKVNAVTEKIFILPASSFCAGG-EEGHDACQGDGGGPLVC-QDDGFYELAGLVSWGFGCG 1020
            ..:|:......:.    :..|:||||. |.|.|:||||.|||..| ::||.:.|||::|||.||.
Worm   864 RFDCVNSSQIYSS----MSRSAFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCA 924

  Fly  1021 RQDVPGVYVKTSSFIGWINQIIS 1043
            ::..||:|...:.::.||:.||:
Worm   925 QKKQPGIYTMVAPYLSWISAIIN 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	80/249 (32%)
svh-1	NP_501379.2	KR	227..306	CDD:214527	15/78 (19%)
		LDLa	320..355	CDD:238060	6/53 (11%)
		PAN_AP_HGF	373..434	CDD:238532	13/115 (11%)
		LDLa	558..590	CDD:197566	7/31 (23%)
		SRCR_2	599..681	CDD:382996	17/166 (10%)
		Tryp_SPc	713..945	CDD:238113	80/249 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24258
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940