DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and PRSS27

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_114154.1	Gene:	PRSS27 / 83886	HGNCID:	15475	Length:	290	Species:	Homo sapiens

Alignment Length:	281	Identity:	99/281 - (35%)
Similarity:	139/281 - (49%)	Gaps:	39/281 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 RLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCI 307
            |:||             ::|||:.:::|.|||...:   ..:||.| |||:||..:.|||||||.
Human    30 RMLN-------------RMVGGQDTQEGEWPWQVSI---QRNGSHF-CGGSLIAEQWVLTAAHCF 77

  Fly   308 RQ----DLQFVRLGEHDLSTDTETG-HVDINIARYV-SHPDYNRRNGRSDMAILYLERNVEFTSK 366
            |.    .|..|.||...|   .:.| |......|.| |:|.|......:|:|::.||..|.||:.
Human    78 RNTSETSLYQVLLGARQL---VQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNY 139

  Fly   367 IAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGG--ESAQVLNELQIPIYDNKVCVQSYAKEKRY 429
            |.|:|||..:.:.:   .|...:|.|||...|..  ...::|.:|.:||.|...|...|:|:..:
Human   140 ILPVCLPDPSVIFE---TGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEF 201

  Fly   430 -FSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVY 493
             :........:||||...|.||.|:|||||||:.   ..|| .:...||:|:|.||||.|.||||
Human   202 GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVC---LVGQ-SWLQAGVISWGEGCARQNRPGVY 262

  Fly   494 SSTQYFMDW---IIQQVQDTP 511
            .......:|   ||.::|..|
Human   263 IRVTAHHNWIHRIIPKLQFQP 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	92/254 (36%)
		Tryp_SPc	261..503	CDD:238113	92/253 (36%)
PRSS27	NP_114154.1	Tryp_SPc	34..272	CDD:214473	91/251 (36%)
PRSS27	NP_114154.1	Tryp_SPc	36..275	CDD:238113	92/252 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910