DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and Tmprss5

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001346389.1	Gene:	Tmprss5 / 80893	MGIID:	1933407	Length:	455	Species:	Mus musculus

Alignment Length:	354	Identity:	108/354 - (30%)
Similarity:	159/354 - (44%)	Gaps:	73/354 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CASL------------LNELR-SRSQDATFANF-LRASNAVCQNKGTQVCCPTGQGITNTTPAPS 230
            |.||            |:::: :|||:  ||.. .|....|.::......||:|
Mouse   148 CKSLGHIRLTQHKAVNLSDIKLNRSQE--FAQLSARPGGLVEESWKPSANCPSG----------- 199

  Fly   231 QIVPKNTDEIPRRLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLI 295
            :||.....|           ||:. ....:||||:....|.|||.|.:    ..||...||.:::
Mouse   200 RIVSLKCSE-----------CGAR-PLASRIVGGQAVASGRWPWQASV----MLGSRHTCGASVL 248

  Fly   296 TARHVLTAAHCIRQDLQFVRLGE---HD--LSTDTETGHVDINIARYVSHPDYNRRNGRSDMAIL 355
            ....|:|||||: ...:..||..   |.  :|......|....:.:.:.||.|:.:|...|:|:|
Mouse   249 APHWVVTAAHCM-YSFRLSRLSSWRVHAGLVSHGAVRQHQGTMVEKIIPHPLYSAQNHDYDVALL 312

  Fly   356 YLERNVEFTSKIAPICLPHTANLRQKSYV-GYMPFVAGWGKT-MEGGESAQVLNELQIPIYD--- 415
            .|...:.|:..:..:|||    .:::.:. |...:|:|||.| .....|:..|.:..:|:..
Mouse   313 QLRTPINFSDTVGAVCLP----AKEQHFPWGSQCWVSGWGHTDPSHTHSSDTLQDTMVPLLSTYL 373

  Fly   416 -NKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVS 479
             |..|:.|.|...|          :||||.|.|..|.|||||||||:.|   .|. .::|:||||
Mouse   374 CNSSCMYSGALTHR----------MLCAGYLDGRADACQGDSGGPLVCP---SGD-TWHLVGVVS 424

  Fly   480 YGIGCARPNVPGVYSSTQYFMDWIIQQVQ 508
            :|.|||.||.||||:....|:|||...||
Mouse   425 WGRGCAEPNRPGVYAKVAEFLDWIHDTVQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855	11/49 (22%)
		Tryp_SPc	260..503	CDD:214473	85/253 (34%)
		Tryp_SPc	261..503	CDD:238113	85/252 (34%)
Tmprss5	NP_001346389.1	SRCR_2	116..213	CDD:317845	19/89 (21%)
Tmprss5	NP_001346389.1	Tryp_SPc	217..448	CDD:214473	85/253 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910