DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and st14a

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001035441.2	Gene:	st14a / 678603	ZFINID:	ZDB-GENE-030131-6496	Length:	834	Species:	Danio rerio

Alignment Length:	395	Identity:	123/395 - (31%)
Similarity:	177/395 - (44%)	Gaps:	87/395 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 APLIEPRGTVCRGPDTKP--GNCVEIKECASLLNELRSRSQDATFANFLRASNAVCQN----KGT 212
            |.:|:.:..:|     ||  ..|..:.:|....:||...         .||....|:|    ...
Zfish   476 AKMIQCKNGLC-----KPMFWRCDGVDDCGDSTDELNCG---------CRADQFKCKNDKCISEK 526

  Fly   213 QVC-----CPTG---QGITNTTP--------APSQIVPKNTDEIPRRLLNVEEGCG--------- 252
            |.|     |..|   :|...|..        ..|:.:.|     |....:.::.||
Zfish   527 QKCDGKDDCNDGSDEEGCARTDSCLVSTFLCGNSKCITK-----PNPECDGQDDCGDNSDESNCN 586

  Fly   253 -STVGYFK-KIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQDLQF-- 313
             .|..|.| :||||:.:.:|.:||...|...:.:   ..|||::|..|.::|||||::.|::.
Zfish   587 CGTKAYKKSRIVGGQDAFEGEFPWQVSLHIKNIA---HVCGGSIINERWIVTAAHCVQDDVKIKY 648

  Fly   314 -------VRLGEH---DLSTDTETGHVDINIARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIA 368
                   |.||.|   |..|.|:.     .:.:.:.||.||.....:|:|::.:|..|.|:..|.
Zfish   649 SQPGTWEVFLGLHSQKDKLTATKR-----LLKQVIPHPYYNAYTYDNDIALMEMESPVTFSDTIR 708

  Fly   369 PICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSAD 433
            |:|||...:...   .|...|::|||.|.|||..|.||.:.::.|.::.||.|        ....
Zfish   709 PVCLPTATDTFP---AGTSVFISGWGATREGGSGATVLQKAEVRIINSTVCNQ--------LMGG 762

  Fly   434 QFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQY 498
            |....:.||||||||.|.|||||||||..|   .|: |.:|.||||:|.||||.|.||:||:...
Zfish   763 QITSRMTCAGVLSGGVDACQGDSGGPLSFP---SGK-RMFLAGVVSWGDGCARRNKPGIYSNVPK 823

  Fly   499 FMDWI 503
            |..||
Zfish   824 FRAWI 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855	13/62 (21%)
		Tryp_SPc	260..503	CDD:214473	94/254 (37%)
		Tryp_SPc	261..503	CDD:238113	94/253 (37%)
st14a	NP_001035441.2	SEA	77..168	CDD:279699
		CUB	219..322	CDD:238001
		CUB	329..431	CDD:238001
		LDLa	443..472	CDD:238060
		LDLa	474..508	CDD:238060	9/36 (25%)
		LDLa	510..544	CDD:238060	8/33 (24%)
		LDLa	550..585	CDD:238060	5/39 (13%)
		Tryp_SPc	596..828	CDD:214473	94/254 (37%)
		Tryp_SPc	597..831	CDD:238113	96/255 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910