DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and PRSS22

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_071402.1	Gene:	PRSS22 / 64063	HGNCID:	14368	Length:	317	Species:	Homo sapiens

Alignment Length:	291	Identity:	98/291 - (33%)
Similarity:	142/291 - (48%)	Gaps:	46/291 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 NTDEIPRRLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHV 300
            |...||     |...||.. ....::||||.|....||||..:    .......|.|:|:|:|.|
Human    31 NAARIP-----VPPACGKP-QQLNRVVGGEDSTDSEWPWIVSI----QKNGTHHCAGSLLTSRWV 85

  Fly   301 LTAAHCIRQDLQ-----FVRLGEHDLSTDTETGHVDINIARYVSHPDYNRRNGR-SDMAILYLER 359
            :|||||.:.:|.     .|.||...|........ .:.:|....||.|:.:.|. :|:|::.|||
Human    86 ITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQ-KVGVAWVEPHPVYSWKEGACADIALVRLER 149

  Fly   360 NVEFTSKIAPICLPHTANLRQKSYVGYMP-----FVAGWGKTMEGG--ESAQVLNELQIPIYDNK 417
            :::|:.::.|||||..:.        ::|     :::|||...:|.  ...|.|.:|::||.|::
Human   150 SIQFSERVLPICLPDASI--------HLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSE 206

  Fly   418 VCVQSYAKEKRYFSADQ--FDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSY 480
            ||...|     :..|.|  ..:.:||||.|.|.:|.|.||||||||.    |....:.|.|::|:
Human   207 VCSHLY-----WRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMC----QVDGAWLLAGIISW 262

  Fly   481 GIGCARPNVPGVYSSTQYFMDW---IIQQVQ 508
            |.|||..|.||||.|......|   |:|.||
Human   263 GEGCAERNRPGVYISLSAHRSWVEKIVQGVQ 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	88/260 (34%)
		Tryp_SPc	261..503	CDD:238113	88/259 (34%)
PRSS22	NP_071402.1	Tryp_SPc	50..288	CDD:238113	88/259 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910