DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and KLK15

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_059979.2	Gene:	KLK15 / 55554	HGNCID:	20453	Length:	256	Species:	Homo sapiens

Alignment Length:	258	Identity:	75/258 - (29%)
Similarity:	124/258 - (48%)	Gaps:	43/258 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 KIVGGEVSRKGAWPW-IALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQDLQFVRLGEHDLST 323
            |::.|:.....:.|| :||  |:   ...|.||.:||:...||:||||..:.:: ||||||:|.
Human    21 KLLEGDECAPHSQPWQVAL--YE---RGRFNCGASLISPHWVLSAAHCQSRFMR-VRLGEHNLR- 78

  Fly   324 DTETGHVDI-NIARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYM 387
             ...|...: ..:|.:.||.|..|:.|:|:.:|.|.:......::.|..||     .:..:.|..
Human    79 -KRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLP-----TRCPHPGEA 137

  Fly   388 PFVAGWGKTM--EGGESAQVLNELQIP---------IYDNKVCVQSYAKEKRYFSADQFDKAVLC 441
            ..|:|||...  |.|.:....:::.:|         |..:..|.:||        ..:....::|
Human   138 CVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSY--------PGRLTNTMVC 194

  Fly   442 AGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYG-IGCARPNVPGVYSSTQYFMDWI 503
            ||....|.::|:|||||||:.     |.:   |.|:||:| :.|.....||||:...::::||
Human   195 AGAEGRGAESCEGDSGGPLVC-----GGI---LQGIVSWGDVPCDNTTKPGVYTKVCHYLEWI 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	73/256 (29%)
		Tryp_SPc	261..503	CDD:238113	72/255 (28%)
KLK15	NP_059979.2	Tryp_SPc	25..249	CDD:214473	72/252 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910