Protein Alignment CG1299 and KLKB1

DIOPT Version :9

• Sequence 1: NP_647862.1
• Gene: CG1299 / 38496
• FlyBaseID: FBgn0035501
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_011530232.1
• Gene: KLKB1 / 3818
• HGNCID: 6371
• Length: 649
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 146/545 - (26%)
• Similarity: 215/545 - (39%)
• Gaps: 128/545 - (23%)

  Fly    30 RRQVRQNCI-------TPE-------------------NYYGSC--VALTYCPQVVNIFQTTSRD 66
            :.:.|.||:       ||.                   :..|:|  .:|..|...:||||.
Human   159 KAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGNCRTTSLCDCGCHMNIFQH---- 219

  Fly    67 RAQRYVIALQRSCGTRSINGDPVICCTEPRYNP------------VTERPRNPFF--------PS 111
                  :|.......|.:..|..:|.|...|:|            ..|..||...        ||
Human   220 ------LAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPS 278

  Fly   112 ESTFIGPQPPPEVPDNPFLIPTPRTTTTTTTTTPAPIPDTSAAPLIEPRG-----TVCRGPDTKP 171
            .||   ||      :|..   :..:..|...|.|.|. .:...|.::..|     |..:|.:...
Human   279 SST---PQ------ENTI---SGYSLLTCKRTLPEPC-HSKIYPGVDFGGEELNVTFVKGVNVCQ 330

  Fly   172 GNCVEIKECA----SLLNELRSRSQDATFANFLRASNAVCQNKGTQVCCPTGQGITNTTPAPSQI 232
            ..|.::..|.    |||.|   ..::.....|||.|   .....|::...| ||.:..:
Human   331 ETCTKMIRCQFFTYSLLPE---DCKEEKCKCFLRLS---MDGSPTRIAYGT-QGSSGYS------ 382

  Fly   233 VPKNTDEIPRRLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITA 297
                     .||.|..:....|.....:||||..|..|.|||...|.. ..:.....|||:||..
Human   383 ---------LRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQV-KLTAQRHLCGGSLIGH 437

  Fly   298 RHVLTAAHCI----RQDLQFVR---LGEHDLSTDTETGHVDINIARYVSHPDYNRRNGRSDMAIL 355
            :.|||||||.    .||:..:.   |...|::.||...    .|...:.|.:|....|..|:|::
Human   438 QWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFS----QIKEIIIHQNYKVSEGNHDIALI 498

  Fly   356 YLERNVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQVLNELQIPIYDNKVCV 420
            .|:..:.:|....|||||...:   .|.:....:|.|||.:.|.||...:|.::.||:..|:.|.
Human   499 KLQAPLNYTEFQKPICLPSKGD---TSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQ 560

  Fly   421 QSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCA 485
            :.|...|       ..:.::|||...||||.|:|||||||:.  .:.|..|  |:|:.|:|.|||
Human   561 KRYQDYK-------ITQRMVCAGYKEGGKDACKGDSGGPLVC--KHNGMWR--LVGITSWGEGCA 614

  Fly   486 RPNVPGVYSSTQYFMDWIIQQVQDT 510
            |...||||:....:||||:::.|.:
Human   615 RREQPGVYTKVAEYMDWILEKTQSS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	15/83 (18%)
		CLIP	164..216	CDD:288855	12/55 (22%)
		Tryp_SPc	260..503	CDD:214473	87/249 (35%)
		Tryp_SPc	261..503	CDD:238113	87/248 (35%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519	5/34 (15%)
		APPLE	212..295	CDD:128519	21/104 (20%)
		APPLE	303..386	CDD:128519	19/105 (18%)
		Tryp_SPc	401..632	CDD:214473	87/249 (35%)
		Tryp_SPc	402..632	CDD:238113	87/248 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910