DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and plg

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_958880.2	Gene:	plg / 322691	ZFINID:	ZDB-GENE-030131-1411	Length:	818	Species:	Danio rerio

Alignment Length:	567	Identity:	159/567 - (28%)
Similarity:	223/567 - (39%)	Gaps:	162/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TPENYYGSCVAL--TYCPQVVN-----IFQTTSRDRAQRYVIALQRSCGTRSINGDPVI-----C 91
            :||||  .|..|  .||....|     .:.|   |...|:......|||.:....:|||     |
Zfish   317 SPENY--PCKGLDGNYCRNPDNERSPWCYTT---DPETRWEYCSVPSCGDQPRPEEPVIPQGEEC 376

  Fly    92 --------------------C-----TEPRYNPVTERPRNPFFPSES-------TFIGPQPP--- 121
                                |     .||..:..|  |:|  ||...       ...|.:.|
Zfish   377 YEGDGSSYRGVMSETISGKKCQFWTSMEPHRHSKT--PQN--FPKADLRRNLCRNPDGDRAPWCY 437

  Fly   122 -------------------PEVPDNPFLIPTPRTTTTTTTTTPAPIPDTSAAPLIEPRGTVCRGP 167
                               |.:.:.|   ..|..||.|.:|.....||.||.          ...
Zfish   438 TTDPTVRWEYCNIERCDNRPNIQEPP---AKPAATTPTQSTPAQSTPDQSAP----------SEK 489

  Fly   168 DTKPGNCVEIKECASL------LNELRSRS--QDATFANFLRASNAV----CQNKGTQVCCPTGQ 220
            |.|.||..|.:...|:      ....||.:  |.|:|.........:    |:|..:.|   .|.
Zfish   490 DCKNGNGAEYRGSTSMTVMGVTCQAWRSMTPHQHASFTPETHPDKGLESNQCRNPDSDV---NGP 551

  Fly   221 GITNTTPAPSQIVPKNTD--EIPRRLLNVEE-GCGSTV----GYFKKIVGGEVSRKGAWPW-IAL 277
            ....|.|:      |..|  :||    :.|. .||...    ..|.:||||.||:..:||| |:|
Zfish   552 WCYTTDPS------KKWDYCQIP----DCESLKCGQPATKPKRCFGRIVGGCVSKPHSWPWQISL 606

  Fly   278 LGYDDPSGSPFKCGGTLITARHVLTAAHCI-RQD---LQFVRLGEHDLSTDTETGHVDINIARYV 338
                ...|....||||||..:.|:|||||: |.|   ...:.||.| ....||:...:.::.:.:
Zfish   607 ----RTRGKIHFCGGTLIDPQWVVTAAHCLERSDSPSAYKIMLGIH-TERATESSKQERDVTKII 666

  Fly   339 SHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMP-----FVAGWGKTME 398
            ..|      ..:|:|:|.|:|......|::|:|||      :|.|:  :|     :|.|||:|.:
Zfish   667 KGP------AGTDIALLKLDRPALINDKVSPVCLP------EKDYI--VPSNTECYVTGWGETQD 717

  Fly   399 -GGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLML 462
             |||.  .|.|...|:.:||||      .:..|...:.....:|||.:.||.|:|||||||||:.
Zfish   718 TGGEG--YLKETGFPVIENKVC------NRPSFLNGRVKDHEMCAGNIEGGNDSCQGDSGGPLVC 774

  Fly   463 PEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQYFMDWIIQQVQD 509
                ..|..|.|.||.|:|:|||....||||:....|:|||.:.:::
Zfish   775 ----YAQNTFVLQGVTSWGLGCANAMKPGVYTRVSKFVDWIERSIKE 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	20/90 (22%)
		CLIP	164..216	CDD:288855	14/63 (22%)
		Tryp_SPc	260..503	CDD:214473	92/253 (36%)
		Tryp_SPc	261..503	CDD:238113	92/252 (37%)
plg	NP_958880.2	PAN_AP_HGF	31..104	CDD:238532
		KR	109..190	CDD:214527
		KR	190..270	CDD:214527
		KR	281..361	CDD:214527	14/48 (29%)
		Kringle	376..453	CDD:306546	11/80 (14%)
		KR	490..572	CDD:214527	21/94 (22%)
		Tryp_SPc	589..813	CDD:238113	94/254 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I4208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910