DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	116/361 - (32%)
Similarity:	164/361 - (45%)	Gaps:	70/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 PRGTVC-RGPDTKPGN----CVEIKECASLLNELRSRSQDATFANFLRASNAVCQNKGTQVCCPT 218
            ||  || |.||...|:    |.|...|.:...:...||       .::..|..|..   |..|..
  Rat   507 PR--VCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRS-------CVKKPNPECDG---QADCRD 559

  Fly   219 GQGITNTTPAPSQIVPKNTDEIPRRLLNVEEGCGSTV-GYFKKIVGGEVSRKGAWPWIALLGYDD 282
            |..                          ||.|...: |...:||||.:|.:|.|||.|.|   .
  Rat   560 GSD--------------------------EEHCDCGLQGPSSRIVGGAMSSEGEWPWQASL---Q 595

  Fly   283 PSGSPFKCGGTLITARHVLTAAHCIRQD------LQFVRLGEHDLSTDTETGHVDINIARYVSHP 341
            ..|... |||.||..|.|:|||||.::|      |..|.||:. .......|.|...::|...||
  Rat   596 IRGRHI-CGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKM-RQNSRWPGEVSFKVSRLFLHP 658

  Fly   342 DYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQVL 406
            .:...:...|:|:|.|:..|.:::.:.|:|||..::..:.   |...::.|||...|||..:..|
  Rat   659 YHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEP---GQHCWITGWGAQREGGPGSSTL 720

  Fly   407 NELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLR 471
            .::.:.:....:|.::|    ||    |....:||||...|.||.|||||||||:..|| .|  |
  Rat   721 QKVDVQLIPQDLCNEAY----RY----QVTPRMLCAGYRKGKKDACQGDSGGPLVCKEP-SG--R 774

  Fly   472 FYLIGVVSYGIGCARPNVPGVYSSTQYFMDWIIQQV 507
            ::|.|:||:|:||.|||..|||:.....::| ||||
  Rat   775 WFLAGLVSWGLGCGRPNFFGVYTRVTRVVNW-IQQV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855	13/56 (23%)
		Tryp_SPc	260..503	CDD:214473	89/248 (36%)
		Tryp_SPc	261..503	CDD:238113	89/247 (36%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060	8/19 (42%)
		Ldl_recept_a	529..566	CDD:278486	10/72 (14%)
		Tryp_SPc	576..806	CDD:214473	90/249 (36%)
		Tryp_SPc	577..809	CDD:238113	92/251 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910