DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1299 and GZMH

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_219491.1	Gene:	GZMH / 2999	HGNCID:	4710	Length:	246	Species:	Homo sapiens

Alignment Length:	260	Identity:	77/260 - (29%)
Similarity:	123/260 - (47%)	Gaps:	41/260 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GCGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQDLQFV 314
            |.|:     ::|:||..::..:.|::|.:.:.... |..:|||.|:....|||||||....:. |
Human    15 GAGT-----EEIIGGHEAKPHSRPYMAFVQFLQEK-SRKRCGGILVRKDFVLTAAHCQGSSIN-V 72

  Fly   315 RLGEHDLSTDTETGHVDINIARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLR 379
            .||.|::.....|... |.:.|.:.||.||.:|..:|:.:|.|||..::|:.:.|:.||.:
Human    73 TLGAHNIKEQERTQQF-IPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSS---- 132

  Fly   380 QKSYV--GYMPFVAGWG----KTMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSADQFDKA 438
             |:.|  |.:..|||||    .|:     |..|.|:.:.:..:..|       :|.|..:.....
Human   133 -KAQVKPGQLCSVAGWGYVSMSTL-----ATTLQEVLLTVQKDCQC-------ERLFHGNYSRAT 184

  Fly   439 VLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQYFMDWI 503
            .:|.|.....:...:|||||||:..:..|        |::|||.....|  ||||....:|:.||
Human   185 EICVGDPKKTQTGFKGDSGGPLVCKDVAQ--------GILSYGNKKGTP--PGVYIKVSHFLPWI 239

Fly 504 503
Human 240 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	73/248 (29%)
		Tryp_SPc	261..503	CDD:238113	73/247 (30%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	75/249 (30%)
GZMH	NP_219491.1	Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910