DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and KLK13

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_056411.1	Gene:	KLK13 / 26085	HGNCID:	6361	Length:	277	Species:	Homo sapiens

Alignment Length:	302	Identity:	92/302 - (30%)
Similarity:	134/302 - (44%)	Gaps:	51/302 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 PTGQGITNTTPAPSQIVPKNTDEIPRRLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPWIALLGYD 281
            |....|.:.|.|.|..|.:.:.::    ||.    ..|.|:   :.||......:.||.|.|...
Human     3 PLALVIASLTLALSGGVSQESSKV----LNT----NGTSGF---LPGGYTCFPHSQPWQAALLVQ 56

  Fly   282 DPSGSPFKCGGTLITARHVLTAAHCIRQDLQFVRLGEHDLSTDTETGHVDINIARYVSHPDYNRR 346
                ....|||.|:..:.|||||||:::.|: |.||:|.|.. .|.|.....:...:.||:|.|.
Human    57 ----GRLLCGGVLVHPKWVLTAAHCLKEGLK-VYLGKHALGR-VEAGEQVREVVHSIPHPEYRRS 115

  Fly   347 ----NGRSDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQV-- 405
                |...|:.:|.|:..|:.|..|..:.|.|...|..    |....|:|||.|    .|.||
Human   116 PTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTP----GTTCRVSGWGTT----TSPQVNY 172

  Fly   406 ---LNELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQ 467
               |....|.:..::.|.|.|        ..:....:||||...||||:|:|||||||:....
Human   173 PKTLQCANIQLRSDEECRQVY--------PGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRT-- 227

  Fly   468 GQLRFYLIGVVSYG-IGCARPNVPGVYSSTQYFMDWIIQQVQ 508
                  |.|:||:| ..|.:|:.||||:....::.||.:.::
Human   228 ------LYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIR 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	80/252 (32%)
		Tryp_SPc	261..503	CDD:238113	80/251 (32%)
KLK13	NP_056411.1	Tryp_SPc	38..261	CDD:238113	82/252 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910