DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and PAMR1

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_056245.2	Gene:	PAMR1 / 25891	HGNCID:	24554	Length:	737	Species:	Homo sapiens

Alignment Length:	523	Identity:	113/523 - (21%)
Similarity:	178/523 - (34%)	Gaps:	139/523 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QNCITPENYYGSCVALTYCPQVVN-----IFQTTSRDRAQRYVIA--LQRSCGTR-SINGDPVIC 91
            :||..|.........:|..|.::|     |....|......||::  .:|:|... ..:|...||
Human   295 RNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 359

  Fly    92 ---CTEPRYNPVTERPRNPF-FPSESTFIGPQPPPEVPDNPFLIPTPRTTTTTTTTTPA-PIPDT 151
               |.||:.:.:..|...|. ..|..|     |..::....|   :.:...:..|..|| |..|.
Human   360 IKACREPKISDLVRRRVLPMQVQSRET-----PLHQLYSAAF---SKQKLQSAPTKKPALPFGDL 416

  Fly   152 SAAPLIEPRGTVCRGPDTKPGNCVEIKECASLLNELRSRSQDATFANFLR---ASNAVCQNKG-- 211
                   |.|                      ...|.::.|....:.|.|   :|...|...|
Human   417 -------PMG----------------------YQHLHTQLQYECISPFYRRLGSSRRTCLRTGKW 452

  Fly   212 ---TQVCCPTGQGITNTTPAPSQIVPKNTD-------EIPRRLLNVEEGCGSTVGYFKKIVGGEV 266
               ...|.|....|.|.|      .||...       .|.||...|.:|.
Human   453 SGRAPSCIPICGKIENIT------APKTQGLRWPWQAAIYRRTSGVHDGS--------------- 496

  Fly   267 SRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQ----------DLQFVRLGEHDL 321
            ..||||..:              |.|.|:..|.|:.||||:..          ||:.| ||:...
Human   497 LHKGAWFLV--------------CSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVV-LGKFYR 546

  Fly   322 STDTETGHV-DINIARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLR---QKS 382
            ..|.:...: .:.|:..:.||:|:.....:|:|||.|......::::.||||..:.:|.   |:|
Human   547 DDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQES 611

  Fly   383 YVGYMPFVAGW---GKTMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGV 444
            ::    .||||   ......|.....|....:.:.|:.:|.:.:  |.........|.....:..
Human   612 HI----TVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQH--EDHGIPVSVTDNMFCASWE 670

  Fly   445 LSGGKDTCQGDSGGPLML-------PEPYQGQLRFYLIGVV--SYGIGCARPNVPGVYSSTQYFM 500
            .:...|.|..::||...:       |||     |::|:|:|  ||...|:. .:...::....|.
Human   671 PTAPSDICTAETGGIAAVSFPGRASPEP-----RWHLMGLVSWSYDKTCSH-RLSTAFTKVLPFK 729

  Fly   501 DWI 503
            |||
Human   730 DWI 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	14/66 (21%)
		CLIP	164..216	CDD:288855	7/59 (12%)
		Tryp_SPc	260..503	CDD:214473	61/268 (23%)
		Tryp_SPc	261..503	CDD:238113	61/267 (23%)
PAMR1	NP_056245.2	CUB	128..234	CDD:238001
		EGF_CA	240..272	CDD:238011
		CCP	297..360	CDD:153056	13/62 (21%)
		CCP	<425..460	CDD:153056	6/34 (18%)
		Tryp_SPc	478..735	CDD:238113	68/297 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910