DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1299 and PRSS55

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	320	Identity:	93/320 - (29%)
Similarity:	151/320 - (47%)	Gaps:	54/320 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGQGITNTTPAPSQIVP-------KNTDEIPRRLLNVEEGCGSTVGY-----FKKIVGGEVSRKG 270
            ||..:...||.|...|.       .:..:.|.....|.| ||....:     :.:|.||..:..|
Human    14 TGTQLGPRTPLPEAGVAILGRARGAHRPQPPHPPSPVSE-CGDRSIFEGRTRYSRITGGMEAEVG 77

  Fly   271 AWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQDLQF-----VRLGEHDLSTDTETGHV 330
            .:||...:   .....|| |||:::....:||||||:..:..|     |.||.:||::.:    :
Human    78 EFPWQVSI---QARSEPF-CGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLTSPS----M 134

  Fly   331 DI-NIARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICL---PHTANLRQKSYVGYMPFVA 391
            :| .:|..:.|.|:.|.|..:|:|:|.|...::......||||   |..|..|:       .:||
Human   135 EIKEVASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWRE-------CWVA 192

  Fly   392 GWGKTMEGGESAQVLNELQIP--IYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQG 454
            |||:|....:::...:.::.|  |.|.:.|.:.:.|         ..|.:||||..:...|.|:|
Human   193 GWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPK---------LTKNMLCAGYKNESYDACKG 248

  Fly   455 DSGGPLM-LPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQYFMDWI--IQQVQDTP 511
            ||||||: .|||.:   ::|.:|::|:|..|...|.||:|:|...:..||  :.|::..|
Human   249 DSGGPLVCTPEPGE---KWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRP 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	78/254 (31%)
		Tryp_SPc	261..503	CDD:238113	78/253 (31%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	78/254 (31%)
		Tryp_SPc	68..298	CDD:238113	80/256 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910