DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and Prss12

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	276	Identity:	88/276 - (31%)
Similarity:	129/276 - (46%)	Gaps:	40/276 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 VEEGCGSTVGY--FKKIVGGEVSRKGAWPWIALLGYDDPSG-SPFKCGGTLITARHVLTAAHCIR 308
            :..|||..:.:  .|:|:||..|.:|||||.|.|......| ....||.||:::..|||||||
Mouse   501 LSSGCGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHC-- 563

  Fly   309 QDLQFVRLGEHDLSTDTETG--HV--------DINIARYVSHPDYNRRNGRSDMAILYL----ER 359
                |.|.|.:..|.....|  |.        :|.:.:.|.|.:|.......|:|::.|    |:
Mouse   564 ----FKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQGPGEQ 624

  Fly   360 NVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQVLNELQIPIYDNKVCVQSYA 424
            ....::.:.|.|||......||:....  .:.|||.|  |...::.|.:..:|:...:.|.:.|
Mouse   625 CARLSTHVLPACLPLWRERPQKTASNC--HITGWGDT--GRAYSRTLQQAAVPLLPKRFCKERY- 684

  Fly   425 KEKRYFSADQFDKAVLCAGVLSGGK--DTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARP 487
              |..|:.     .:||||.|....  |:||||||||||..:|.:.   :.:.||.|:|.||...
Mouse   685 --KGLFTG-----RMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDES---WVVYGVTSWGYGCGVK 739

  Fly   488 NVPGVYSSTQYFMDWI 503
            :.||||:....|:.||
Mouse   740 DTPGVYTRVPAFVPWI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	82/259 (32%)
		Tryp_SPc	261..503	CDD:238113	82/258 (32%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516		2/10 (20%)
		Tryp_SPc	516..755	CDD:214473	82/259 (32%)
		Tryp_SPc	517..758	CDD:238113	84/260 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910