DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and PRSS21

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_006790.1	Gene:	PRSS21 / 10942	HGNCID:	9485	Length:	314	Species:	Homo sapiens

Alignment Length:	268	Identity:	99/268 - (36%)
Similarity:	130/268 - (48%)	Gaps:	34/268 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 CGSTVGYFKKIVGGEVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAHCIR--QDLQ- 312
            ||..| ...:|||||.:..|.|||...|...|    ...||.:|::.|..||||||..  .||.
Human    33 CGRRV-ITSRIVGGEDAELGRWPWQGSLRLWD----SHVCGVSLLSHRWALTAAHCFETYSDLSD 92

  Fly   313 ----FVRLGEHDLSTDTETGHVDINIARY-VSH----PDYNRRNGRSDMAILYLERNVEFTSKIA 368
                .|:.|:  |::......:.....|| ||:    |.| ..|...|:|::.|...|.:|..|.
Human    93 PSGWMVQFGQ--LTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQ 154

  Fly   369 PICL-PHTANLRQKSYVGYMPFVAGWG--KTMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYF 430
            |||| ..|.....::..    :|.|||  |..|...|...|.|:|:.|.:|.:|...:.|..  |
Human   155 PICLQASTFEFENRTDC----WVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS--F 213

  Fly   431 SADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSS 495
            ..|.|...| |||...||||.|.|||||||...:  .|  .:|.|||||:|:||.|||.||||::
Human   214 RKDIFGDMV-CAGNAQGGKDACFGDSGGPLACNK--NG--LWYQIGVVSWGVGCGRPNRPGVYTN 273

  Fly   496 TQYFMDWI 503
            ..:..:||
Human   274 ISHHFEWI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829
		CLIP	164..216	CDD:288855
		Tryp_SPc	260..503	CDD:214473	94/257 (37%)
		Tryp_SPc	261..503	CDD:238113	94/256 (37%)
PRSS21	NP_006790.1	Tryp_SPc	42..283	CDD:238113	96/258 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910