DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1299 and tmprss2.15

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_031752206.1	Gene:	tmprss2.15 / 101732233	XenbaseID:	XB-GENE-22065943	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	139/545 - (25%)
Similarity:	216/545 - (39%)	Gaps:	136/545 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KSMCCVSAVITLLPLVLLPPPTVAQFNQRRQVRQNCITPENYYGSCV-------ALTYCPQVVNI 59
            |.:|.||....|:...::.....:.:......|.:|.......|:||       .::.||   |.
Frog    54 KIVCIVSIAFGLIGAAIIIAVLCSNYASMPVTRSDCEKECGTNGTCVLSAQWCDGVSDCP---NG 115

  Fly    60 FQTTSRDRAQRYVIALQRSCGTRSI---------------NGDPVICCTEPRYNPVTERPRNPFF 109
            ...||..:.:    |.|..||:..:               ||.....|.. .|.|..:  ...:.
Frog   116 EDETSCVQTR----ACQMLCGSSGVCVLYSQWCDGIPQCPNGTDEQTCVR-LYGPNFQ--LQAYS 173

  Fly   110 PSESTFIGPQPPPEVPDNPFLIPTPRTTTTTTTTTPAPIPDTSAAPLIEPRGTVCRGPDTKPGNC 174
            |:::|:: |....|..||                                .|.:.         |
Frog   174 PAKATWL-PVCYDEWSDN--------------------------------SGKIA---------C 196

  Fly   175 VEIKECASLL---NELRSRSQDATFANFLRASNAVCQNKGTQVCCPTGQGITN----TTPAPSQI 232
            .:|....|..   ::|.:.|.:..|.  |::||.            ||:..||    .|.|...:
Frog   197 QDIGYSMSSYYQSSQLLASSSNGYFV--LQSSNV------------TGKMYTNLNYSATCASGNM 247

  Fly   233 VPKNTDEIPRRLLNVEEGCGSTVGYFKKIVGGEVSRKGAWPW----IALLGYDDPSGSPFKCGGT 293
            |       ..|.::    ||.:.....:||||..:..|.|||    :.|:|     .|.:.|||:
Frog   248 V-------SLRCIS----CGLSTKVDSRIVGGTPASVGDWPWQVELLKLVG-----TSIYLCGGS 296

  Fly   294 LITARHVLTAAHCIRQDLQF-----VRLGEHDLSTDTETGHVDINIARYVSHPDYNRRNGRSDMA 353
            :||...::|||||:......     |..|...:.:....|:   .:.|.:.||.|:......|:|
Frog   297 IITPHWIVTAAHCVYGSTSTPSAFKVFAGSLTIQSYYSAGY---TVERALVHPSYSSYTQIYDVA 358

  Fly   354 ILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESAQVLNELQIPIYDNKV 418
            :|.|...:.||:.:.|:|||   |:......|...:::|||.|.|||..::.|....:||..:..
Frog   359 LLKLTAALVFTTNLRPVCLP---NVGMPWAEGQPCWISGWGTTAEGGSISKNLMAASVPIISSTT 420

  Fly   419 CVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIG 483
            |.|:..    |..|  ....::|||.||||.|||||||||||:.    :....::|:|..|:|.|
Frog   421 CNQAAV----YGGA--ISSTMMCAGYLSGGTDTCQGDSGGPLVT----KTNSLWWLVGDTSWGYG 475

  Fly   484 CARPNVPGVYSSTQYFMDWIIQQVQ 508
            |||...||||.:...|::||..|:|
Frog   476 CARAYKPGVYGNVTVFIEWIYSQMQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	15/77 (19%)
		CLIP	164..216	CDD:288855	9/54 (17%)
		Tryp_SPc	260..503	CDD:214473	85/251 (34%)
		Tryp_SPc	261..503	CDD:238113	85/250 (34%)
tmprss2.15	XP_031752206.1	LDLa	93..121	CDD:238060	7/30 (23%)
		SRCR_2	164..259	CDD:406055	27/163 (17%)
		Tryp_SPc	265..498	CDD:238113	87/253 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910