DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1299 and klkb1

DIOPT Version :9

Sequence 1:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_002934450.3	Gene:	klkb1 / 100486524	XenbaseID:	XB-GENE-985051	Length:	629	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	125/505 - (24%)
Similarity:	203/505 - (40%)	Gaps:	147/505 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YYGSCVALTYCPQVVNIFQTTSRDRAQRYVIALQRSC---------GTRSINGDPVICCT-EPRY 97
            :|.:|:..|:       ::..|::..||.|..::.|.         ...:|:|..::.|. .|..
Frog   232 FYPNCLFFTF-------YKKESKEPLQRNVCYIRTSTKGIPDEGINKEHTISGFSLLSCKFSPSV 289

  Fly    98 NPVTERPRNPFFPSESTFIGPQPPPEVPDNPFLIPTPRTTTTTTTTTPAPIPDTSAAPLIEPRGT 162
            .|:|       ..|::.|:|.:                                   .|:|
Frog   290 CPLT-------ILSDAEFLGDE-----------------------------------LLVE---- 308

  Fly   163 VCRGPDTKPGNCVEI---KEC-ASLLNELRSRSQDATFANFLRASNAVCQNKGTQVC-C------ 216
                         |:   ||| ....|.:|.:     |..:....:...:||    | |
Frog   309 -------------EVSGEKECQQECTNNIRCQ-----FFTYRPMQSGCSENK----CKCHMKISS 351

  Fly   217 ---PTGQGITNTTPAPSQIVPKNTDEI---PRRLLNVE--EGCGSTVGYFKKIVGGEVSRKGAWP 273
               |||             :.....||   ..||..::  :|||..:.:..:||||..|..|.||
Frog   352 NGLPTG-------------IRHGNGEISGFSLRLCKIKSVKGCGEPIEHANRIVGGTDSVLGEWP 403

  Fly   274 W-IALLGYDDPSGSPFKCGGTLITARHVLTAAHCIRQ----DLQFVRLGEHDLSTDTETGHVDIN 333
            | :::......|.....|||::|:.:.::|||||...    .:..:..|...||..|::.... .
Frog   404 WQVSMHLRLTASYKKHACGGSIISNQWIVTAAHCFAMHPLPQMWIIYSGVVKLSNITQSTPFS-E 467

  Fly   334 IARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMP---FVAGWGK 395
            ..:.:.||.|......:|:|:|.|:..:.|......||||.    |:.::|  :|   ::.|||.
Frog   468 TEQIIIHPHYTGAGNGTDIALLKLKTPISFNDHQKAICLPP----REPTFV--LPNSCWITGWGF 526

  Fly   396 TMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVLSGGKDTCQGDSGGPL 460
            |.|.|..|.:|.:.::|....:.|..:|.:.:       .||.:||||...|..|:|:|||||||
Frog   527 TEESGSLANILQKAEVPQISTEECQGNYEQTR-------IDKKILCAGYKRGKIDSCKGDSGGPL 584

  Fly   461 --MLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQYFMDWIIQQVQ 508
              ::.|.:      ||.|:.|:|.|||||..||||:....|.||||:..:
Frog   585 ACVVDEIW------YLTGITSWGEGCARPGKPGVYTRVSEFTDWIIEHTR 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	10/58 (17%)
		CLIP	164..216	CDD:288855	10/56 (18%)
		Tryp_SPc	260..503	CDD:214473	82/252 (33%)
		Tryp_SPc	261..503	CDD:238113	82/251 (33%)
klkb1	XP_002934450.3	APPLE	21..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519	10/57 (18%)
		APPLE	290..373	CDD:128519	24/163 (15%)
		Tryp_SPc	391..626	CDD:238113	85/254 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910