DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras64B and RAP2A

DIOPT Version :9

Sequence 1:	NP_523917.2	Gene:	Ras64B / 38494	FlyBaseID:	FBgn0003206	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_066361.1	Gene:	RAP2A / 5911	HGNCID:	9861	Length:	183	Species:	Homo sapiens

Alignment Length:	188	Identity:	81/188 - (43%)
Similarity:	126/188 - (67%)	Gaps:	11/188 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQTYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFS 67
            |:.||:||:|.|||||||:|:||:...|:..|||||||.|.|:..:|..|:.|:||||||.|:|:
Human     1 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFA 65

  Fly    68 AMREQYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRVKDRDEFPMLMVGNKCDLKHQQQVSLEE 132
            :||:.|:::|:||:||::|.:..||.:|...:.||:|||..::.|:::||||.||:.:::||..|
Human    66 SMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSE 130

  Fly   133 AQNTSRNLMIPYIECSAKLRVNVDQAFHELVRIVRKFQIAERPFIEQDYKKKGKRKCC 190
            .:..:.....|::|.|||.:..||:.|.|   |||:...|.:|  ::|      ..||
Human   131 GRALAEEWGCPFMETSAKSKTMVDELFAE---IVRQMNYAAQP--DKD------DPCC 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras64B	NP_523917.2	M_R_Ras_like	4..167	CDD:133345	73/162 (45%)
RAP2A	NP_066361.1	Rap2	3..165	CDD:133376	75/164 (46%)
RAP2A	NP_066361.1	Effector region. /evidence=ECO:0000305	32..40		7/7 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810