Protein Alignment Ras64B and RASD2

DIOPT Version :10

• Sequence 1: NP_523917.2
• Gene: Ras64B / 38494
• FlyBaseID: FBgn0003206
• Length: 192
• Species: Drosophila melanogaster
• Sequence 2: NP_055125.2
• Gene: RASD2 / 23551
• HGNCID: 18229
• Length: 266
• Species: Homo sapiens
• Alignment Length: 188
• Identity: 73/188 - (38%)
• Similarity: 104/188 - (55%)
• Gaps: 30/188 - (15%)

  Fly     5 TYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFSAM 69
            :|::||:|...||||:|..:|:...|...|.|||||.:.|..||.....:||||||:|...|.||
Human    19 SYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAM 83

  Fly    70 REQYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRV--------KDRDEFPMLMVGNKCDLKHQQ 126
            |...:.:|:.|:|||:|::..||||:.:.|:|||.|        |:..|.||::.|||.|  |.:
Human    84 RRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKND--HGE 146

  Fly   127 ---QVSLEEAQNTSRNLMI------PYIECSAKLRVNVDQAFHELVRIVRKFQIAERP 175
               ||...||:     |::      .|.|.|||...|||:.|:.|      |.:|:.|
Human   147 LCRQVPTTEAE-----LLVSGDENCAYFEVSAKKNTNVDEMFYVL------FSMAKLP 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ras64B	NP_523917.2	M_R_Ras_like	4..167	CDD:133345	70/178 (39%)
RASD2	NP_055125.2	Rhes_like	20..266	CDD:133343	73/187 (39%)
		Effector region	48..56		6/7 (86%)
		Interaction with GNB1, GNB2 and GNB3. /evidence=ECO:0000269|PubMed:19255495	189..235		2/5 (40%)