DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras64B and let-60

DIOPT Version :9

Sequence 1:	NP_523917.2	Gene:	Ras64B / 38494	FlyBaseID:	FBgn0003206	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_502213.3	Gene:	let-60 / 178104	WormBaseID:	WBGene00002335	Length:	184	Species:	Caenorhabditis elegans

Alignment Length:	190	Identity:	106/190 - (55%)
Similarity:	136/190 - (71%)	Gaps:	6/190 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQTYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFS 67
            |..|||||||.|||||||:|||.||::||.:|||||||||.||..||.....|||||||||||:|
Worm     1 MTEYKLVVVGDGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

  Fly    68 AMREQYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRVKDRDEFPMLMVGNKCDLKHQQQVSLEE 132
            |||:||||:|||||||||:|:..||:.:..::.||.||||.|:.||::|||||||. .:.|....
Worm    66 AMRDQYMRTGEGFLLVFAVNEAKSFENVANYREQIRRVKDSDDVPMVLVGNKCDLS-SRSVDFRT 129

  Fly   133 AQNTSRNLMIPYIECSAKLRVNVDQAFHELVRIVRKFQIAERPFIEQDYKKKGKRKCCLM 192
            ...|::...||.::.|||.|:.||:||:.|||.:||.:  ||   ..:.|.:.|:||.:|
Worm   130 VSETAKGYGIPNVDTSAKTRMGVDEAFYTLVREIRKHR--ER---HDNNKPQKKKKCQIM 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras64B	NP_523917.2	M_R_Ras_like	4..167	CDD:133345	96/162 (59%)
let-60	NP_502213.3	H_N_K_Ras_like	3..164	CDD:133338	96/161 (60%)
let-60	NP_502213.3	small_GTPase	16..166	CDD:197466	86/150 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750