DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras64B and RHEBL1

DIOPT Version :9

Sequence 1:	NP_523917.2	Gene:	Ras64B / 38494	FlyBaseID:	FBgn0003206	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_653194.1	Gene:	RHEBL1 / 121268	HGNCID:	21166	Length:	183	Species:	Homo sapiens

Alignment Length:	186	Identity:	49/186 - (26%)
Similarity:	100/186 - (53%)	Gaps:	10/186 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFSAMRE 71
            |:|::|...|||:::..||::..|...||||:|::|:|...:......|.::|||||:|:|.:..
Human     8 KVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPY 72

  Fly    72 QYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRVKDRDEFPMLMVGNKCDLKHQQQVSLEEAQNT 136
            .::....|::||:::....||..|....:::.....:...|:::||||.||..:::|...|.:..
Human    73 SFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNKADLSPEREVQAVEGKKL 137

  Fly   137 SRNLMIPYIECSAKLRVNVDQAFHELVRIVRKFQIAERPFIEQDYKKKGKRKCCLM 192
            :.:....::|.||:........|.::::.:.:        :|..|.:  :|:|.||
Human   138 AESWGATFMESSARENQLTQGIFTKVIQEIAR--------VENSYGQ--ERRCHLM 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras64B	NP_523917.2	M_R_Ras_like	4..167	CDD:133345	43/159 (27%)
RHEBL1	NP_653194.1	small_GTPase	5..169	CDD:197466	43/160 (27%)
		RheB	6..183	CDD:206709	47/184 (26%)
		Effector region	35..43		5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810