DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and SEC1

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_010448.1	Gene:	SEC1 / 851742	SGDID:	S000002571	Length:	724	Species:	Saccharomyces cerevisiae

Alignment Length:	634	Identity:	158/634 - (24%)
Similarity:	295/634 - (46%)	Gaps:	84/634 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RVLVVDKLGMRMVSACTKMHEISAEGITLVEDINK-KREPLPTMDAIYLITPSDESVRGLIRDF- 102
            :.|::||....::|......:.....:|.|:.|:. .|:...:::|||::.|:..::..:..||
Yeast    26 KFLIIDKTVETILSYLFLTPQELLNNVTSVDLIDSPTRKGQSSIEAIYILEPTKYNINCIDADFM 90

  Fly   103 ENPARPMYRYAHVFFTEVCPEELFNDL-CKSCAAGKIKTLKEINIAFLPYECQVF-SLDSPDTFQ 165
            ..|  |.||..|:.|.......:|... .|...|..:::.|.|.:.|...|.|.| :|....:.|
Yeast    91 VRP--PKYRRCHIRFLPGLTNPIFQFFQSKRYIAQNLESFKPIELGFFVKESQFFETLQMEHSLQ 153

  Fly   166 CLYSPAFASIRSKHIERIAEQIATLCATLGEYPNVRY------RSDWDRN-----------IDLA 213
            ..::....::...::.:|...:.:||...||||.|||      ..:..||           ..:|
Yeast   154 VFFNNNCKALIPTNVRKIVGSLVSLCVITGEYPIVRYSVSNPVEEEDARNGNAVVNANSLTRSIA 218

  Fly   214 ASVQQKLDAYKADDATM-GEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVN---DV 274
            .:.|..:|.|..::... .:..|:.||.|:|.||..|..:|:||:.:.|||||||:..|:   |:
Yeast   219 NAFQIAIDTYARNNPDFPPQNTERPRSILIITDRTLDPFAPILHDFSYQAMAYDLVANVDTQKDI 283

  Fly   275 YRYT----PGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSKRMGSADKSSMR- 334
            |.|:    .|..:.....|:|..|..|::|:|:||...:..:...:|:.. :|.....|:|:::
Yeast   284 YHYSAENEAGEQEEKVSKLVDLYDPDWIDLKHQHIMDANEYIQGRIKELI-AKNPLLVDRSNVKN 347

  Fly   335 --DLSQMIKKMPQYQKELSKYSTHLHLAEDCM-KSYQNYVDKLCRVEQDLA-MGTDAEGEKIKDH 395
              ||..::..:..:.:|..:...|..|.::|: ::.:..:..:..:||:|: .|.|..|||||..
Yeast   348 TTDLLSVVAHLKDFDEERRRLILHKTLVDECLGENAERKLADISAIEQNLSGFGMDFSGEKIKHI 412

  Fly   396 MRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQD------MVRNLSC 454
            :.:::|.|.....:..||:|.|..|.:.:.||.|.:..||.....::.:.::      :.||...
Yeast   413 IDDLLPALAMKEPTILDKLRYIIAYALFRGGIIELDFIKLLNFIGVTHEHENFQQYLKIFRNYDL 477

  Fly   455 LGINVIADSRKKQYSVPRKERTTEST-------YQMSRWTPVIKDIMEDCIEDKLDL--RHFPFL 510
            :...:|.|..|.:   |.::.....|       |..||:.|.:.:|:...|.:.|.|  ::||:|
Yeast   478 IDFKLIKDKPKDK---PFQKEWFHDTLVNDPNIYHTSRFVPAVGNILSKVIANPLLLSEQYFPYL 539

  Fly   511 EGR-------------AQNTNYHAPTSARYGHWHK----DKGQAQVKNVP--RLIVFIVGGVSMS 556
            :.:             ..||:.::.:|.|... ||    .|.....||:|  |...:::||:|:.
Yeast   540 KDKPIELLNEEEFQAGLANTSANSSSSLRNPR-HKAAWTTKSSNIKKNIPRQRFFYYVIGGISIP 603

  Fly   557 EMRCAYEVTNAVRNWEVLVGSSHILSPEIFLSDLGSLS--------KED 597
            |::.||:.:| ::|.::.:||..||:|..||.::..|.        |||
Yeast   604 EIKAAYDQSN-LKNRDIFIGSDEILTPTKFLDEVERLQNPREFFKFKED 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	151/610 (25%)
SEC1	NP_010448.1	SEC1	1..644	CDD:227487	155/625 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I756
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I989
Isobase	1	0.950	-	0	Normalized mean entropy	S1338
OMA	1	1.010	-	-		QHG53928
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	1	1.000	-	-		oto99743
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2284
SonicParanoid	1	1.000	-	-		X527
TreeFam	1	0.960	-	-
	14	13.810