Protein Alignment Rop and VPS33

DIOPT Version :9

• Sequence 1: NP_001261404.1
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_013500.3
• Gene: VPS33 / 851112
• SGDID: S000004388
• Length: 691
• Species: Saccharomyces cerevisiae
• Alignment Length: 762
• Identity: 128/762 - (16%)
• Similarity: 254/762 - (33%)
• Gaps: 287/762 - (37%)

  Fly    24 KKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGITLVEDINKKREPLPTMDAIYLI 88
            ||..:|:|.|                    .|..::|||..                  |.:.::
Yeast     8 KKFSLTNADG--------------------LCATLNEISQN------------------DEVLVV 34

  Fly    89 TPSDESVRGLIRDFEN-----PARPMYRYAHVFFTEVCPEELFNDLCKSCAAGKIKTLKEINIAF 148
            .||...|...:..|::     |.|.:         .:..::|.:||  ..|.|.:   .::::.|
Yeast    35 QPSVLPVLNSLLTFQDLTQSTPVRKI---------TLLDDQLSDDL--PSALGSV---PQMDLIF 85

  Fly   149 ---------LPYE----CQVFSLDSPDTFQCLYSPAFAS--------------IRSK--HIERIA 184
                     ||.:    .|..:|.|.....|.:.|:|.:              :.||  |...:.
Yeast    86 LIDVRTSLRLPPQLLDAAQKHNLSSLHIIYCRWKPSFQNTLEDTEQWQKDGFDLNSKKTHFPNVI 150

  Fly   185 E-QIATLC-------------ATLGE-----------------YPNVRYRSDWDRNI---DLAAS 215
            | |:..|.             ..:.|                 |||:|.......:|   |:..|
Yeast   151 ESQLKELSNEYTLYPWDLLPFPQIDENVLLTHSLYNMENVNMYYPNLRSLQSATESILVDDMVNS 215

  Fly   216 VQ----------------------------QKLDAYKADDATMGEGP---EKA----RSQLLILD 245
            :|                            :::|.::.::....:|.   |:.    ...|:||:
Yeast   216 LQSLIFETNSIITNVVSIGNLSKRCSHLLKKRIDEHQTENDLFIKGTLYGERTNCGLEMDLIILE 280

  Fly   246 RGFDCVSPLLHELTLQAMAYDLLPIVNDVYRYTPGPNQPDKEVLLD-ENDDLWVELRHEHIAVVS 309
            |..|.::|||.:||...       |::|:|.:..|....:|::..: :.|.:|.:|:..:...:.
Yeast   281 RNTDPITPLLTQLTYAG-------ILDDLYEFNSGIKIKEKDMNFNYKEDKIWNDLKFLNFGSIG 338

  Fly   310 TQVTQNLKKFT---DSKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMK-----S 366
            .|:.:..|:..   |::...    .|:.::.:.:..:...|:..:....|..|:.|.:|     .
Yeast   339 PQLNKLAKELQTQYDTRHKA----ESVHEIKEFVDSLGSLQQRQAFLKNHTTLSSDVLKVVETEE 399

  Fly   367 YQNYVDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEEN 431
            |.:: :|:..:|.::.||.....: |:|   .|:.:.....|.....:|:|.|..:.||.:.|
Yeast   400 YGSF-NKILELELEILMGNTLNND-IED---IILELQYQYEVDQKKILRLICLLSLCKNSLRE-- 457

  Fly   432 LTKLFTHAQLSPKDQDMVRNL--------SCLGINVIAD---------------------SRKKQ 467
                        ||.:.:|..        .|..:..:|:                     ..:|:
Yeast   458 ------------KDYEYLRTFMIDSWGIEKCFQLESLAELGFFTSKTGKTDLHITTSKSTRLQKE 510

  Fly   468 Y--------SVP------------RKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRH-----F 507
            |        :||            ..:..:|:|:..|...|:...::: .:.|:..|.|     .
Yeast   511 YRYISQWFNTVPIEDEHAADKITNENDDFSEATFAYSGVVPLTMRLVQ-MLYDRSILFHNYSSQQ 574

  Fly   508 PFLEGRAQNTNYHAPTSAR-YGHWH------------KDKGQAQVKNVPR--------------- 544
            ||:..|....:.......: ||..|            ..|..|.:|:..|
Yeast   575 PFILSREPRVSQTEDLIEQLYGDSHAIEESIWVPGTITKKINASIKSNNRRSIDGSNGTFHAAED 639

  Fly   545 --LIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHILSPEIFLSD 589
              |:||: |||:|.|:.       .:::.:.::|...|....|.::|
Yeast   640 IALVVFL-GGVTMGEIA-------IMKHLQKILGKKGINKRFIIIAD 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	121/738 (16%)
VPS33	NP_013500.3	SEC1	14..651	CDD:227487	119/720 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810