DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and SEC1B

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_567388.1	Gene:	SEC1B / 826820	AraportID:	AT4G12120	Length:	662	Species:	Arabidopsis thaliana

Alignment Length:	670	Identity:	200/670 - (29%)
Similarity:	321/670 - (47%)	Gaps:	121/670 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGITLVEDIN 73
            ::|:.|:::     |::.      |:..:.|:|||:||..::::|:..||.||:.|||:|||.|.
plant    24 ERLLCEMLR-----PERN------GSSKLTWKVLVMDKFTVKIMSSACKMSEITQEGISLVEVIT 77

  Fly    74 KKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKSCAAGK- 137
            |.|:|:..|:.||.|.|::|:|...:.|....: |:|:.|.|||:......|.|.:.|...|.|
plant    78 KHRQPMTAMEVIYFIQPTEENVTAFLSDMTGKS-PLYKKAFVFFSSPVSRSLVNLIKKDMRAMKR 141

  Fly   138 IKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKH-IERIAEQIATLCATLGEYPNVR 201
            |..|||:|:.::..:.|.|..::.:..:.|:.......|:.. :..:|::|||:.|:|.|||.||
plant   142 IGGLKEMNLEYISMDIQGFVTNNENALEELFCDDENHQRADACLNVVAKRIATVLASLKEYPFVR 206

  Fly   202 YRSDWDRNID--------------LAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVS 252
            ||.  .:.:|              |||||...|..||   .|:.:.|:....:||||||..|.::
plant   207 YRG--AKALDATTMTTYRELIPTKLAASVWNCLARYK---QTIEDFPQTETCELLILDRSIDQIA 266

  Fly   253 PLLHELTLQAMAYDLLPIVNDVYRY----TPGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVT 313
            ||:||.|..||.:|||.:..:.|.:    ..|.....|||||||.|.:|||||..|||..|.::.
plant   267 PLIHEWTYDAMCHDLLNMEGNKYTHEVPSKTGDKPEKKEVLLDEEDSIWVELRDAHIADASERLH 331

  Fly   314 QNLKKFTDSKRMGSADKS-------SMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKS-YQNY 370
            :.:..|....:......|       |.:||.:|:..:|||.:::.|.|.|:.:|....:: .:..
plant   332 EKMTNFVSKNKAAQLKHSSKDFGDLSSKDLQKMVHALPQYSEQIDKLSLHVEIARTINRTIMEQG 396

  Fly   371 VDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDAN--VSNYDKVRIIALYVMI-KNGISEENL 432
            :..|.::||||..|.....:.||         .|..|  :|:..|:|:|.:...| ......|..
plant   397 LRDLGQLEQDLVFGDAGRKDVIK---------FLSTNHIISHESKLRLIMIVAAIYPKKFEGEKG 452

  Fly   433 TKLFTHAQLSPKDQDMVRNLSCLGINVIADSRK-------------KQYSVPRKERTTES-TYQM 483
            .|:...|:||..|...|.|:..|| .|..:.:|             |.....|::|..|: |:|:
plant   453 RKMMELAKLSGDDVVAVNNMRLLG-PVHTECKKSTTGSFPLKFDVLKTKRAARRDRVGETQTWQL 516

  Fly   484 SRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQN----TNYHA----------PTSARYGHW---- 530
            ||:.|::::::|     ||...|.|..:....|    |.|..          |.|.|...|
plant   517 SRFYPIVEELVE-----KLSKGHLPKQDYPCMNEPKPTFYSGSLSPSASPVLPHSRRTPTWARRH 576

  Fly   531 ------------------HKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGS 577
                              .|.|||       |:.||||||.:.||:|..:::|..: :.||::||
plant   577 LSDDGYFSDSVLGRASSGFKRKGQ-------RIFVFIVGGATRSELRVCHKLTEKL-DREVILGS 633

  Fly   578 SHILSPEIFLSDLGSLSKED 597
            |..|.|..||:.:..|::|:
plant   634 SSFLDPLTFLTKMKQLNEEE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	190/623 (30%)
SEC1B	NP_567388.1	Sec1	44..438	CDD:279352	135/408 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	234	1.000	Domainoid score	I627
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2382
Inparanoid	1	1.050	243	1.000	Inparanoid score	I1066
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D725424at2759
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	1	1.000	-	-		otm3245
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840