Protein Alignment Rop and Scfd1

DIOPT Version :9

• Sequence 1: NP_001261404.1
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_084101.1
• Gene: Scfd1 / 76983
• MGIID: 1924233
• Length: 639
• Species: Mus musculus
• Alignment Length: 681
• Identity: 132/681 - (19%)
• Similarity: 266/681 - (39%)
• Gaps: 132/681 - (19%)

  Fly     6 LVGQKL-------------MNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTK 57
            :||.|:             :..::.:..|..|.       ..|...|:||:.|:.|..::|....
Mouse     1 MVGSKMAATASIRERQTVALKRMLNFNVPHVKN-------STGEPVWKVLIYDRFGQDIISPLLS 58

  Fly    58 MHEISAEGITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCP 122
            :.|:...||||...::..|:|:|.:.|:|.:.|::|::..|.:|..|   .:|...::.|.....
Mouse    59 VKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDLRN---QLYESYYLNFISAIS 120

  Fly   123 EELFNDLCKSC-AAGKIKTLKEI---NIAFLPYECQVFSLDSPD----TFQCLYSPAFASIRSKH 179
            .....|:..:. ||..:..:.::   .:.|:..|..:|.|.:.:    :::.:..|.......:.
Mouse   121 RSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMET 185

  Fly   180 I-ERIAEQIATLCATLGEYPNVRYRSDWDRNIDLAASVQQKL-----DA----YKADDATMGEGP 234
            : :.|.:.:.....|||..|.:|........: :|..:.:||     ||    :..|  .:|.|.
Mouse   186 VMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEM-VAVKLDKKLRENLRDARNSLFTGD--PLGTGQ 247

  Fly   235 EKARSQLLIL-DRGFDCVSPLLHELTLQAMAYDLLPI-VNDV-------YRYTPGPNQP----DK 286
            ...:..||:| ||..|..:||.|..|.||:.:|:|.. :|.|       ...:|...:|    .|
Mouse   248 FSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTGVENSPAGARPKRKNKK 312

  Fly   287 EVLLDENDDLWVELRHEHIAVVSTQVTQNLKKF----TDSKRMGS------ADKSSMRDLS---- 337
            ...|...|..|.:.:......|:..|.|.|:.:    .:.||:.|      .|:.::..||
Mouse   313 SYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTA 377

  Fly   338 ---QMIKKMPQYQKELSKYSTHLHLAEDCMKSYQ-NYVDKLCRVEQDLAMGTDAEGEKIKDHMRN 398
               ..:..:|:..::......|.::|...::..: ..:|.....|:.:...|..:        ::
Mouse   378 KLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLD--------KS 434

  Fly   399 IVPILLDANVSN-YDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDM---VRNLSCLGINV 459
            ::.::.|.:... .||:|:..:|               :..||.:|.:.|:   .:.|:..|.|:
Mouse   435 LLDVISDPDAGTPEDKMRLFLIY---------------YISAQQAPSEVDLEQYKKALTDAGCNL 484

  Fly   460 IADSRKKQYSVPRKERTTESTYQMSRWTPV----------IKDIMEDCIEDKLDLRHFP------ 508
            ......||:....|..:|.::|..:...|:          .:.:||......|..::.|
Mouse   485 SPLQYIKQWKAFAKMASTPASYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILD 549

  Fly   509 -FLEGRAQNTNYHAPTSARYGHWHKDKGQAQVKNVPR-------LIVFIVGGVSMSEMRCAYEVT 565
             .:|.::.      |.:..|.::.....::...:|||       .|||:|||.:..|.:...:..
Mouse   550 NLMEMKSN------PETDDYRYFDPKMLRSNDSSVPRNKSPFQEAIVFVVGGGNYIEYQNLVDYI 608

  Fly   566 NAVRNWEVLVGSSHILSPEIFLSDLGSLSKE 596
            .|.:...:|.|.|.|.:...|:..|..|.::
Mouse   609 KAKQGKHILYGCSEIFNATQFIKQLSQLGQK 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	122/619 (20%)
Scfd1	NP_084101.1	Sec1	41..626	CDD:307231	122/619 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810