Protein Alignment Rop and STXBP3

DIOPT Version :9

• Sequence 1: NP_001261404.1
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_009200.2
• Gene: STXBP3 / 6814
• HGNCID: 11446
• Length: 592
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 265/602 - (44%)
• Similarity: 399/602 - (66%)
• Gaps: 39/602 - (6%)

  Fly     3 LKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT 67
            ||.:|.||:...|.    ...||:|          ||:::::|:...:::::|.||.::..||||
Human    10 LKSVVWQKIKATVF----DDCKKEG----------EWKIMLLDEFTTKLLASCCKMTDLLEEGIT 60

  Fly    68 LVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKS 132
            :||:|.|.|||:..|.|:|.|||:.:||...:.||.:.:...|:.|:::||:.||:.|||.:..|
Human    61 VVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKAS 125

  Fly   133 CAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKH--IERIAEQIATLCATLG 195
            |:. .|:..|||||:|:|:|.||::||.||.|...|||...:.:.|.  :|.:|:||.|:||||.
Human   126 CSK-SIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLD 189

  Fly   196 EYPNVRYRS-DWDRNIDLAASVQQKL-DAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHEL 258
            |.|.|||:| ..|....||..|::|| |.||.|:.::.:|  |..|||||:|||||.||.:||||
Human   190 ENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKG--KTHSQLLIIDRGFDPVSTVLHEL 252

  Fly   259 TLQAMAYDLLPIVNDVYRY-TPGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDS 322
            |.||||||||||.||.|:| |.|   .:||.:|:|.|||||.:||.|||||..::.:.:|:.:.:
Human   253 TFQAMAYDLLPIENDTYKYKTDG---KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISST 314

  Fly   323 KRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDA 387
            |: .:..|:|:..|:|::||||.::|:::|...||:||||||..::..::|||:.|||||:||||
Human   315 KK-ATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDA 378

  Fly   388 EGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNL 452
            ||:|:||.||.::|:||:.|..|.||:|.|.||:...||.:||||.:|..:.::. .:.||:||.
Human   379 EGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIE-NESDMIRNW 442

  Fly   453 SCLGINVIADSRKKQYSVP-RKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQN 516
            |.||:.::..|   |...| ||:|:.|.|:|:|||||.|||||||.|:::||.:.:|:.......
Human   443 SYLGVPIVPQS---QQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAV 504

  Fly   517 TNYHAPTSARY---GHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSS 578
            .|.....|||.   .::.:|:     ||..:||||::||::.||:||||||:.|.::.||::||:
Human   505 WNGSGAVSARQKPRANYLEDR-----KNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGST 564

  Fly   579 HILSPEIFLSDLGSLSK 595
            |:|:|:..|.|:..|:|
Human   565 HVLTPKKLLDDIKMLNK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	249/551 (45%)
STXBP3	NP_009200.2	Mediates interaction with DOC2B. /evidence=ECO:0000250	1..255		111/261 (43%)
		Sec1	33..569	CDD:307231	249/551 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.890