Protein Alignment Rop and STXBP2

DIOPT Version :10

• Sequence 1: NP_523916.2
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001258963.1
• Gene: STXBP2 / 6813
• HGNCID: 11445
• Length: 604
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 332/614 - (54%)
• Similarity: 440/614 - (71%)
• Gaps: 42/614 - (6%)

  Fly     3 LKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT 67
            ||.:||:|:::.|::    ..||.|          ||:||::|...||::|:|.||.:|.|||||
Human     6 LKAVVGEKILSGVIR----SVKKDG----------EWKVLIMDHPSMRILSSCCKMSDILAEGIT 56

  Fly    68 LVEDINKKREPLPTMDAIYLITPSD-----------ESVRGLIRDFENPARPMYRYAHVFFTEVC 121
            :||||||:|||:|:::||||::|::           :||:.||:||:......|:.||:|||:.|
Human    57 IVEDINKRREPIPSLEAIYLLSPTEKAQAQRVIHLPQSVQALIKDFQGTPTFTYKAAHIFFTDTC 121

  Fly   122 PEELFNDLCKSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQ 186
            ||.||::|.:|..|..:||||||::||||||.||||||:|.:...||.|..|..|::.:|.:|:|
Human   122 PEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQ 186

  Fly   187 IATLCATLGEYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCV 251
            ||||||||.|||.:|||...:....||.:|..||:|:|||..::||||||.||||||:||..|.|
Human   187 IATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 251

  Fly   252 SPLLHELTLQAMAYDLLPIVNDVYRY-TPGPNQP-DKEVLLDENDDLWVELRHEHIAVVSTQVTQ 314
            ||||||||.||||||||.|..|.||| |.|.::. :|.|||||:|||||||||.|||.||.:||:
Human   252 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTE 316

  Fly   315 NLKKFTDSKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQ 379
            .|:.|.:|||: :.||::::||||::||||||||||:|||||||||:||||.::..|:|||.|||
Human   317 LLRTFCESKRL-TTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQ 380

  Fly   380 DLAMGTDAEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPK 444
            |||||:|||||||||.|:.|||:||||.|..|||:|::.||::::||:|||||.||..||.:. .
Human   381 DLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQ-A 444

  Fly   445 DQDMVRNLSCLGINVI------ADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLD 503
            ...::|||..||..|.      ..||.:    ||:.  .|.|||:|||||||||:|||.:||:||
Human   445 HSSLIRNLEQLGGTVTNPGGSGTSSRLE----PRER--MEPTYQLSRWTPVIKDVMEDAVEDRLD 503

  Fly   504 LRHFPFLEGRAQNTNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAV 568
            ...:||:...|...:..|..|||:|||||:|...:.:..|||||:::|||:|||||.|||||.|.
Human   504 RNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRAT 568

  Fly   569 R-NWEVLVGSSHILSPEIFLSDLGSLSKE 596
            . .||||:||||||:|..||.||.:|.|:
Human   569 EGKWEVLIGSSHILTPTRFLDDLKALDKK 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_523916.2	Sec1	40..589	CDD:460020	317/568 (56%)
STXBP2	NP_001258963.1	Sec1	29..590	CDD:460020	317/568 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..477		7/27 (26%)