Protein Alignment Rop and STXBP1

DIOPT Version :10

• Sequence 1: NP_523916.2
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_003156.1
• Gene: STXBP1 / 6812
• HGNCID: 11444
• Length: 603
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 380/593 - (64%)
• Similarity: 469/593 - (79%)
• Gaps: 17/593 - (2%)

  Fly     1 MALKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEG 65
            :.||.:||:|:|::|:|    ..||:|          ||:|||||:|.|||:|:|.||.:|..||
Human     4 IGLKAVVGEKIMHDVIK----KVKKKG----------EWKVLVVDQLSMRMLSSCCKMTDIMTEG 54

  Fly    66 ITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLC 130
            ||:||||||:|||||:::|:||||||::||..||.||::|....||.||||||:.||:.|||:|.
Human    55 ITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELV 119

  Fly   131 KSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLG 195
            ||.||..||||.||||||||||.||:||||.|:||..|||..|.:::..:||:|||||||||||.
Human   120 KSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLK 184

  Fly   196 EYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTL 260
            |||.||||.::..|..||..:|.|||||||||.||||||:||||||||||||||..||:|||||.
Human   185 EYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTF 249

  Fly   261 QAMAYDLLPIVNDVYRY-TPGPNQPD-KEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSK 323
            |||:||||||.||||:| |.|..:.. |||||||:||||:.|||:|||.||.:||::||.|:.||
Human   250 QAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSK 314

  Fly   324 RMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAE 388
            ||.:.:|::|||||||:|||||||||||||||||||||||||.||..||||||||||||||||||
Human   315 RMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAE 379

  Fly   389 GEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNLS 453
            ||||||.||.|||||||||||.|||:|||.||:.:||||:||||.||..|||:.|:|.:::.|::
Human   380 GEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMA 444

  Fly   454 CLGINVIADSRKKQYSVP-RKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQNT 517
            .||:.::.||..::.|.| ||||.:|.|||:|||||:|||||||.||||||.:|:|::..|:..:
Human   445 HLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSAS 509

  Fly   518 NYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHILS 582
            ......|||||||||:|...:.::.||||:||:||||::|||||||||.|...||||:||:|||:
Human   510 FSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILT 574

  Fly   583 PEIFLSDL 590
            |..||.||
Human   575 PTKFLMDL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_523916.2	Sec1	40..589	CDD:460020	365/551 (66%)
STXBP1	NP_003156.1	Sec1	29..579	CDD:460020	363/549 (66%)