DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and STXBP1

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_003156.1	Gene:	STXBP1 / 6812	HGNCID:	11444	Length:	603	Species:	Homo sapiens

Alignment Length:	593	Identity:	380/593 - (64%)
Similarity:	469/593 - (79%)	Gaps:	17/593 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEG 65
            :.||.:||:|:|::|:|    ..||:|          ||:|||||:|.|||:|:|.||.:|..||
Human     4 IGLKAVVGEKIMHDVIK----KVKKKG----------EWKVLVVDQLSMRMLSSCCKMTDIMTEG 54

  Fly    66 ITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLC 130
            ||:||||||:|||||:::|:||||||::||..||.||::|....||.||||||:.||:.|||:|.
Human    55 ITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELV 119

  Fly   131 KSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLG 195
            ||.||..||||.||||||||||.||:||||.|:||..|||..|.:::..:||:|||||||||||.
Human   120 KSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLK 184

  Fly   196 EYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTL 260
            |||.||||.::..|..||..:|.|||||||||.||||||:||||||||||||||..||:|||||.
Human   185 EYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTF 249

  Fly   261 QAMAYDLLPIVNDVYRY-TPGPNQPD-KEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSK 323
            |||:||||||.||||:| |.|..:.. |||||||:||||:.|||:|||.||.:||::||.|:.||
Human   250 QAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSK 314

  Fly   324 RMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAE 388
            ||.:.:|::|||||||:|||||||||||||||||||||||||.||..||||||||||||||||||
Human   315 RMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAE 379

  Fly   389 GEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNLS 453
            ||||||.||.|||||||||||.|||:|||.||:.:||||:||||.||..|||:.|:|.:::.|::
Human   380 GEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMA 444

  Fly   454 CLGINVIADSRKKQYSVP-RKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQNT 517
            .||:.::.||..::.|.| ||||.:|.|||:|||||:|||||||.||||||.:|:|::..|:..:
Human   445 HLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSAS 509

  Fly   518 NYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHILS 582
            ......|||||||||:|...:.::.||||:||:||||::|||||||||.|...||||:||:|||:
Human   510 FSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILT 574

  Fly   583 PEIFLSDL 590
            |..||.||
Human   575 PTKFLMDL 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	362/545 (66%)
STXBP1	NP_003156.1	Sec1	29..575	CDD:395791	362/545 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141605
Domainoid	1	1.000	733	1.000	Domainoid score	I103
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2382
Inparanoid	1	1.050	757	1.000	Inparanoid score	I559
Isobase	1	0.950	-	0	Normalized mean entropy	S1338
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	1	1.000	-	-		otm41488
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2284
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750