DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and Vps33b

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_071622.1	Gene:	Vps33b / 64060	RGDID:	620644	Length:	617	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	133/577 - (23%)
Similarity:	231/577 - (40%)	Gaps:	113/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 KMHEISAEGITLVEDINK------------KREPLPTMDAIYLITPSDESVRGLIRDFENPARPM 109
            |.||:  :.:..||  ||            .|..:.||..|..:..:|: :.|.:|.::....|.
  Rat    59 KQHEV--DKLYKVE--NKLTLSSNEQLCFLVRPRIKTMRYIANLVNADK-LAGRVRKYKIILSPQ 118

  Fly   110 YRYAHVFFTEVCPEELFNDLCKSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFAS 174
            ..||.....|  .|.::.|:  ||        .|...:.||.:..:.|::.|:.|:    ..|..
  Rat   119 KFYACEMVLE--EEGVYGDV--SC--------DEWAFSLLPLDVDLLSMELPEFFR----DYFLE 167

  Fly   175 IRSKHIERIAEQIATLCATLGEYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARS 239
            ...:.|..:|:.:..|....|.:||.   ....|...::..:.:||:. :.|..|.|..||  ..
  Rat   168 GDQRWINTVAQALHLLSTLYGPFPNC---YGIGRCTKMSYDLWRKLEE-EEDSETKGRRPE--IG 226

  Fly   240 QLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVYRYTPGPNQPDK--EVLLDENDDLWVELRH 302
            .:.:|||..|.|:.|..::..:.:..|...|......:.|.....||  :|||:..|.::.|:|:
  Rat   227 HIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKCGSVDFGPEVTSSDKSLKVLLNAEDKVFSEIRN 291

  Fly   303 EHIAVV---STQVTQNLKKFTDSKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCM 364
            ||.:.|   .:|..:||:...| :|.|...|.....:||.:|.:.|..:.|   |.|:...|..|
  Rat   292 EHFSNVFGFLSQKARNLQAQYD-RRRGMDIKQMKNFVSQELKGLKQEHRLL---SLHIGACESIM 352

  Fly   365 --KSYQNYVDKLCRVEQDLAMGTDAEGEK--IKDHMRNIVPILLDANVSNYDKVRIIALYVMIKN 425
              |:.|:: .:|.:.|..|..|.:.....  |::|        :|..||..:.:|::.|..:.:|
  Rat   353 KKKTKQDF-QELIKTEHALLEGFNIRESTSYIEEH--------IDRQVSPIESLRLMCLLSITEN 408

  Fly   426 GISEENLTKLFTHAQLSPKDQDMVRNLSCLGINVIADSRKKQY----------SVPRKERTTEST 480
            |              |.|||   .|:|            |.||          :.....|....|
  Rat   409 G--------------LIPKD---YRSL------------KTQYLQSYGPEHLLTFSNLRRAGLLT 444

  Fly   481 YQMSRWT-PVIKDIMEDCIEDKLDLRHFPFLEGRAQNTNYHAPTSARYGHWHKDKGQAQVKNVPR 544
            .|.|..| ..:::.:...:.||...:........|:.:|:.| .|.:.....:..|:..:| |||
  Rat   445 EQASGDTLTAVENKVSKLVTDKAAGKITDAFSSLAKRSNFRA-ISKKLNLIPRVDGEYDLK-VPR 507

  Fly   545 LIVFIVGG--VSMSEMRCAYEVTNAVRNWEVLVGSSHILSPEIFLSDLG--SLSKED 597
            .:.::..|  |.:| .|...:|.:. |:|:.|.....:|:    .||..  .::|||
  Rat   508 DMAYVFSGAYVPLS-CRIIEQVLDR-RSWQGLDEVVRLLN----CSDFAFTDMAKED 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	128/559 (23%)
Vps33b	NP_071622.1	Sec1	37..405	CDD:279352	92/385 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810