DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and Vps45

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	129/594 - (21%)
Similarity:	262/594 - (44%)	Gaps:	92/594 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGITLVE--DINKKREPLPTMDAIYLITPSD 92
            |.:|.|   .:::::||....::|......::....:.|.|  |..:..|.|..:..|..|.|:.
  Fly    16 SESGPG---MKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTK 77

  Fly    93 ESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKSCAAGKIKTLKEINIAFLPYECQVFS 157
            ::::.|..:..||....|   :::|:.:.|......|.:...:..::.:||:...:|.....:||
  Fly    78 QNIQLLANELRNPKYSAY---YIYFSNIIPRTDIKYLAECDESESVREVKELYADYLCVNPNLFS 139

  Fly   158 LDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLGEYPNVRYRSDWDRNIDLAASVQQKL-- 220
            |..|:   |:   |..:.....:.|..:.|..:..:|...|.:|||:.......||..:.:::
  Fly   140 LGIPN---CM---ANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQITK 198

  Fly   221 DAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVYRYTPGPNQPD 285
            ::...|..:..:|  .|...||:|||..|.|:||||:.|.|||.::||.|.|:....:..||.|.
  Fly   199 ESSLFDFRSNMDG--AAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVPK 261

  Fly   286 --KEVLLD-ENDDLWVELRHEHIAVVSTQVTQNLKKF----TDSKRMGSADKSSMRDLSQMIKKM 343
              ||::|. :.||.:....:.:...:.:.:.|.:::|    .|.|::     .|:.|:...|:..
  Fly   262 DFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKANDHKKV-----ESIADMKNFIESY 321

  Fly   344 PQYQKELSKYSTHL-HLAEDCMKSYQNYVDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDAN 407
            ||::|.......|| .:.|....|.:..:.::..:||::|...:...:     ::.|..::.|..
  Fly   322 PQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQ-----LQRIKKLIADER 381

  Fly   408 VSNYDKVRIIALYVM----------------IK-NGISEENLTKLFTHAQLSPKDQD---MVRNL 452
            ||..|.::::|||.:                || .|.....:..|..:|....:..|   |||
  Fly   382 VSIDDALKLVALYALRYERHANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVRQGDLFNMVR-- 444

  Fly   453 SCLGINVIADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDK-LDLRHFPFLEGRAQN 516
                   |.|:.|...::.:..:..|:.:  ::.||::|:.:||..:.: || ..||.:  .::.
  Fly   445 -------ITDAVKLTRNLIKGLKGVENVF--TQHTPLLKETLEDVFKGRELD-PLFPAI--NSEL 497

  Fly   517 TNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHIL 581
            ..:..|..                   .::|||:||.:..|....:::.||  .::|::|.:.|.
  Fly   498 VPFRRPPQ-------------------EVVVFIIGGATYEEALAVHQLNNA--GYKVILGGTTIH 541

  Fly   582 SPEIFLSDL 590
            :.:.|:.::
  Fly   542 NSQSFIQEV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	125/575 (22%)
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	125/575 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840