Protein Alignment Rop and stxbp3

DIOPT Version :10

• Sequence 1: NP_523916.2
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_998636.1
• Gene: stxbp3 / 406780
• ZFINID: ZDB-GENE-040426-2833
• Length: 590
• Species: Danio rerio
• Alignment Length: 600
• Identity: 263/600 - (43%)
• Similarity: 388/600 - (64%)
• Gaps: 36/600 - (6%)

  Fly     3 LKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT 67
            ||.:|.|::.:.::                 |...:|.:|::|....|::|:|.||.::.:|||:
Zfish     9 LKKIVWQRIRDTII-----------------ADCKKWNILILDDFTTRLLSSCCKMSDLMSEGIS 56

  Fly    68 LVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKS 132
            ::|::.|.|||:|.|.|||.:.|:.|.:...|.||:  .:|.|:.|:||||:.||:|||:.:.|:
Zfish    57 VLENLFKNREPVPDMKAIYFMAPTVECIDAFINDFK--PKPKYKAAYVFFTDYCPDELFDKMKKN 119

  Fly   133 CAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLGEY 197
            ||. .||..|||||:|||.|.|||:.::|:.|:.:|| .|:..|.|.:::||:||.||||||.||
Zfish   120 CAK-HIKKCKEINISFLPQEAQVFTCENPEAFKKIYS-GFSQDREKTLDKIADQIVTLCATLDEY 182

  Fly   198 PNVRYRSDWDRNID--LAASVQQKLDA-YKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELT 259
            |.|||:.:......  ||..|..||.. |:.|:.|..:  ||..:||||:||..|.|||:|||||
Zfish   183 PGVRYKRESTPGYGKMLAELVDNKLARHYELDEITTKK--EKTPAQLLIVDRAMDPVSPILHELT 245

  Fly   260 LQAMAYDLLPIVNDVYRYTPGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFT---D 321
            .|||||||:||.|::|.|.. .:...||.||:|:|:|||:|||.|||.|:.|:.:.:|..:   |
Zfish   246 YQAMAYDLIPINNNIYEYKM-KDGSKKEALLNEDDELWVKLRHRHIAEVTEQIPKLVKDISASRD 309

  Fly   322 SKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTD 386
            .|:.|.. |.::..|||::||||.::|:.::.:.|||||||.|..||..|:|||:.|||||:|.|
Zfish   310 EKQQGDG-KITIGALSQLMKKMPAFRKQETQKTVHLHLAEDLMGHYQKNVEKLCKAEQDLAVGAD 373

  Fly   387 AEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRN 451
            |||:|:||.||.::|:||..: ...||:|.:.||:...||.:.|||.||..:.::..|| ..::|
Zfish   374 AEGQKVKDPMRTLLPVLLHQH-DTTDKIRAVLLYIFSLNGTTTENLNKLIQNVKIEDKD-GYIQN 436

  Fly   452 LSCLGINVIADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQN 516
            .:.||:.:::.|...: .|.|::|:.:.||.:|||||||||||||.:|:|||::.:||.......
Zfish   437 WNQLGVPILSSSNSSR-KVARRDRSEQETYNVSRWTPVIKDIMEDAVENKLDIKDWPFQSECPSA 500

  Fly   517 TNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHIL 581
            .|.....|||  ..||......:||..|||:|::||||.|||||||||||..::.||::||:|||
Zfish   501 WNGSRAVSAR--QKHKGSSPGDMKNGSRLIIFVLGGVSYSEMRCAYEVTNTNKSCEVIIGSTHIL 563

  Fly   582 SPEIFLSDLGSLSKE 596
            :|...|.|:.:|.|:
Zfish   564 TPRSLLEDIYNLGKK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_523916.2	Sec1	40..589	CDD:460020	254/554 (46%)
stxbp3	NP_998636.1	Sec1	30..571	CDD:460020	254/553 (46%)