DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and stxbp3

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_009294850.1	Gene:	stxbp3 / 406780	ZFINID:	ZDB-GENE-040426-2833	Length:	593	Species:	Danio rerio

Alignment Length:	608	Identity:	264/608 - (43%)
Similarity:	390/608 - (64%)	Gaps:	49/608 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT 67
            ||.:|.|::.:.::                 |...:|.:|::|....|::|:|.||.::.:|||:
Zfish     9 LKKIVWQRIRDTII-----------------ADCKKWNILILDDFTTRLLSSCCKMSDLMSEGIS 56

  Fly    68 LVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKS 132
            ::|::.|.|||:|.|.|||.:.|:.|.:...|.||:  .:|.|:.|:||||:.||:|||:.:.|:
Zfish    57 VLENLFKNREPVPDMKAIYFMAPTVECIDAFINDFK--PKPKYKAAYVFFTDYCPDELFDKMKKN 119

  Fly   133 CAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLGEY 197
            ||. .||..|||||:|||.|.|||:.::|:.|:.:|| .|:..|.|.:::||:||.||||||.||
Zfish   120 CAK-HIKKCKEINISFLPQEAQVFTCENPEAFKKIYS-GFSQDREKTLDKIADQIVTLCATLDEY 182

  Fly   198 PNVRYRSDWDRNID--LAASVQQKLDA-YKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELT 259
            |.|||:.:......  ||..|..||.. |:.|:.|..:  ||..:||||:||..|.|||:|||||
Zfish   183 PGVRYKRESTPGYGKMLAELVDNKLARHYELDEITTKK--EKTPAQLLIVDRAMDPVSPILHELT 245

  Fly   260 LQAMAYDLLPIVNDVYRYTPGPNQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFT---D 321
            .|||||||:||.|::|.|.. .:...||.||:|:|:|||:|||.|||.|:.|:.:.:|..:   |
Zfish   246 YQAMAYDLIPINNNIYEYKM-KDGSKKEALLNEDDELWVKLRHRHIAEVTEQIPKLVKDISASRD 309

  Fly   322 SKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTD 386
            .|:.|.. |.::..|||::||||.::|::::.:.|||||||.|..||..|:|||:.|||||:|.|
Zfish   310 EKQQGDG-KITIGALSQLMKKMPAFRKQVTQKTVHLHLAEDLMGHYQKNVEKLCKAEQDLAVGAD 373

  Fly   387 AEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRN 451
            |||:|:||.||.::|:||..: ...||:|.:.||:...||.:.|||.||..:.::..|| ..::|
Zfish   374 AEGQKVKDPMRTLLPVLLHQH-DTTDKIRAVLLYIFSLNGTTTENLNKLIQNVKIEDKD-GYIQN 436

  Fly   452 LSCLGINVIADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLE----- 511
            .:.||:.:::.|...: .|.|::|:.:.||.:|||||||||||||.:|:|||::.:||..
Zfish   437 WNQLGVPILSSSNSSR-KVARRDRSEQETYNVSRWTPVIKDIMEDAVENKLDIKDWPFQSECPSA 500

  Fly   512 ---GRAQNTNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEV 573
               .||...     .|||  ..||......:||..|||:|::||||.|||||||||||..::.||
Zfish   501 WNGSRAVRV-----LSAR--QKHKGSSPGDMKNGSRLIIFVLGGVSYSEMRCAYEVTNTNKSCEV 558

  Fly   574 LVGSSHILSPEIFLSDLGSLSKE 596
            ::||:|||:|...|.|:.:|.|:
Zfish   559 IIGSTHILTPRSLLEDIYNLGKK 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	253/556 (46%)
stxbp3	XP_009294850.1	Sec1	30..568	CDD:279352	253/555 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.890