DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rop and stxbp2

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_998454.1	Gene:	stxbp2 / 406578	ZFINID:	ZDB-GENE-040426-2482	Length:	595	Species:	Danio rerio

Alignment Length:	598	Identity:	324/598 - (54%)
Similarity:	436/598 - (72%)	Gaps:	24/598 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT 67
            ||.:..:|:::.|:|    ..||.|          :|:||:||.:.||::|:|.||.:|.|||:|
Zfish     6 LKAIANEKILSGVIK----SVKKDG----------DWKVLIVDHISMRILSSCCKMSDIMAEGVT 56

  Fly    68 LVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLCKS 132
            :||||:|:|||:|:::|||||:|..:||..||.||...|. .|:.||||||:.||:.||.::.:|
Zfish    57 IVEDISKRREPIPSLEAIYLISPVPKSVHALIADFRETAF-TYKAAHVFFTDTCPDGLFAEIGRS 120

  Fly   133 CAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASI--RSKHIERIAEQIATLCATLG 195
            ..|..||||||||:||:|||.|||:||:|.:|...|||...::  :|:.:|.:||||||||.||.
Zfish   121 RVAKVIKTLKEINVAFIPYESQVFTLDNPSSFHAFYSPTQTNLDDKSRMMEAMAEQIATLCDTLT 185

  Fly   196 EYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTL 260
            |||.:|||.....|..||..|..:|:|:|||:..||||.:||||||||:|||:|.|||:|||||.
Zfish   186 EYPAIRYRLGPKENFSLAEMVMDRLNAHKADNPRMGEGTDKARSQLLIVDRGYDPVSPILHELTF 250

  Fly   261 QAMAYDLLPIVNDVYRY-TPGPNQP-DKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSK 323
            ||||||||.|..|:||| |.|..:. ||||||||:|:|||:|||.|||.|:.:||:.|:.|.|||
Zfish   251 QAMAYDLLDIEQDIYRYQTAGIGEARDKEVLLDEDDELWVQLRHMHIADVTKKVTELLRVFCDSK 315

  Fly   324 RMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAE 388
            || :.||::::|||||:|||||||||||.|||||:||:.|||.::|.:||||.||||||||:||:
Zfish   316 RM-NTDKANIKDLSQMLKKMPQYQKELSLYSTHLNLADACMKKFKNTLDKLCEVEQDLAMGSDAQ 379

  Fly   389 GEKIKDHMRNIVPILLDANVSNYDKVRIIALYVM-IKNGISEENLTKLFTHAQLSPKDQDMVRNL 452
            ||.:||.|::|||:||:..:.:|||:|||.||:. .|.||.|||||||..||.:. :|::::.||
Zfish   380 GEPLKDAMKSIVPVLLNTEIKDYDKIRIILLYIFHKKKGIGEENLTKLIQHANVQ-QDKNIITNL 443

  Fly   453 SCLGINVIADSRKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQ-N 516
            ..||..:|........|:|.::..||||||:|||.||:||:||:.|:||.|.:.:|||...|. .
Zfish   444 QHLGCPIITGGANSGKSLPDRKERTESTYQLSRWIPVLKDVMENIIDDKCDRKQWPFLSEPAPIT 508

  Fly   517 TNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAV-RNWEVLVGSSHI 580
            |.....:|||:|||||:|...:.::.||||:|::|||:.||||||||||.|. ..||||:|||||
Zfish   509 TTATTVSSARFGHWHKNKSATEYRSGPRLIIFVIGGVTHSEMRCAYEVTRATGGKWEVLIGSSHI 573

  Fly   581 LSPEIFLSDLGSL 593
            ::|..||:||..|
Zfish   574 ITPTSFLNDLKEL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	309/549 (56%)
stxbp2	NP_998454.1	Sec1	29..576	CDD:279352	309/549 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2284
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820