DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and car

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001259707.1	Gene:	car / 32947	FlyBaseID:	FBgn0000257	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	124/641 - (19%)
Similarity:	240/641 - (37%)	Gaps:	148/641 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RVLVVDKLGMRMVSACTKMHEISAEGITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFEN 104
            :|:|:|:..:..:...|:....:..||.|:....:...|....:.:|::.|....:..|....:.
  Fly    36 KVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELHLPREVANVVYVMRPRVALMEQLAAHVKA 100

  Fly   105 PARPMY-RYAHVFFTE----VCPEELFNDLCKSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTF 164
            ..|... |..|:.|..    :|..:|.    .|...|....::|:...:||.:..:.|::.|:.|
  Fly   101 GGRAAAGRQYHILFAPRRSCLCVSQLE----VSGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAF 161

  Fly   165 Q---------CLYSPAFASIRSKHIERIAEQIATLCATLGEYPNVRYRSDWDRNIDLAASVQQKL 220
            :         .||..|...::   ::|:          .|..|.:..:.::      |..|.:..
  Fly   162 RDVSVDGDTSSLYQAAVGLVQ---LQRL----------YGRIPKIYGKGEF------AHRVWEHA 207

  Fly   221 DAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVY-----RYT-P 279
            .....|:.|:..|.:....||::|||..|.:|||..:||.:.       ::::.|     :.| |
  Fly   208 KQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEG-------LIDEFYGIRQNKLTLP 265

  Fly   280 GPNQPD--------------------------KEVLLDENDDLWVELRHEHIAVVSTQVTQNLKK 318
            ..|.|.                          |.:||...:.|:.|||::|...|:..:.:..::
  Fly   266 AENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARKARE 330

  Fly   319 FTDSKRMGSADKSSMRDLSQMIKKMPQYQKELSKYSTH------LHLAEDCMKSYQNYVDKLCRV 377
            ........|.|||.....|.:...:||...:....|.|      ||...:.::    :.|.|. .
  Fly   331 IHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVR----FADDLA-A 390

  Fly   378 EQDLAMGTDAEGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLS 442
            ||:..:..|.  :|...::.:::...::.|    ..:|:|.:.....:|..|    ||..|.:
  Fly   391 EQEFMVCADI--DKPSAYIEDLIACRVELN----RVLRLICMQCHAASGFKE----KLLNHYK-- 443

  Fly   443 PKDQDMVR-----------NLSCLGINVIADSRKKQYSVPRKE-----------RTTESTYQMSR 485
               :::|.           ||...|: :...:..:.|||.||.           ...:.:|..|.
  Fly   444 ---RELVHVYGLEVLLTISNLEKSGL-LHLQTESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSF 504

  Fly   486 WTPVIKDIMEDCIED------KLDLRHFP---FLEGRAQNTNY---HAPTSARYGHWHKDKGQAQ 538
            :.|:...|:|..::.      |..:.:.|   |.:.:||....   |..|:...|         .
  Fly   505 YAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEG---------S 560

  Fly   539 VKNVPRLI-VFIVGGVSMSEMRC-AYEVTNAVRNWEVLVGSSHILSPEIFLSDLGS 592
            :.||||:: |..|||.:.:|:.. .:.......|.|.|:.::.:::...||..|.|
  Fly   561 LLNVPRVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLMS 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	120/630 (19%)
car	NP_001259707.1	Sec1	36..606	CDD:279352	120/629 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840